메뉴 건너뛰기




Volumn 48, Issue SUPPL. 2, 2009, Pages

Febuxostat: A new treatment for hyperuricaemia in gout

Author keywords

Adverse events; Allopurinol; Clinical studies; Febuxostat; Gout; sUA target; Urate lowering therapy

Indexed keywords

ALLOPURINOL; COLCHICINE; CYTOCHROME P450 2D6; DESIPRAMINE; FEBUXOSTAT; HYDROCHLOROTHIAZIDE; INDOMETACIN; NAPROXEN; PLACEBO; WARFARIN;

EID: 65849386648     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kep088     Document Type: Conference Paper
Times cited : (87)

References (31)
  • 1
    • 33748608331 scopus 로고    scopus 로고
    • EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    • Zhang W, Doherty M, Bardin T et al. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2006;65:1312-24.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1312-1324
    • Zhang, W.1    Doherty, M.2    Bardin, T.3
  • 2
    • 35448936489 scopus 로고    scopus 로고
    • British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of gout
    • Jordan KM, Cameron JS, Snaith M et al. British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of gout. Rheumatology 2007;46:1372-4.
    • (2007) Rheumatology , vol.46 , pp. 1372-1374
    • Jordan, K.M.1    Cameron, J.S.2    Snaith, M.3
  • 3
    • 28944437578 scopus 로고    scopus 로고
    • Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    • Becker MA, Schumacher HR Jr, Wortmann RL et al. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005;353:2450-61.
    • (2005) N Engl J Med , vol.353 , pp. 2450-2461
    • Becker, M.A.1    Schumacher Jr, H.R.2    Wortmann, R.L.3
  • 4
    • 0031662935 scopus 로고    scopus 로고
    • Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. A pathogenic approach to the treatment of primary chronic gout
    • Perez-Ruiz F, Alonso-Ruiz A, Calabozo M, Herrero-Beites A, Garcia-Erauskin G, Ruiz-Lucea E. Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. A pathogenic approach to the treatment of primary chronic gout. Ann Rheum Dis 1998;57:545-9.
    • (1998) Ann Rheum Dis , vol.57 , pp. 545-549
    • Perez-Ruiz, F.1    Alonso-Ruiz, A.2    Calabozo, M.3    Herrero-Beites, A.4    Garcia-Erauskin, G.5    Ruiz-Lucea, E.6
  • 5
    • 0021366307 scopus 로고
    • Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency
    • Hande KR, Noone RM, Stone WJ. Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency. Am J Med 1984;76: 47-56.
    • (1984) Am J Med , vol.76 , pp. 47-56
    • Hande, K.R.1    Noone, R.M.2    Stone, W.J.3
  • 6
    • 0033511044 scopus 로고    scopus 로고
    • A comparative study on the hypouricemic activity and potency in renal xanthine calculus formation of two xanthine oxidase/xanthine dehydrogenase inhibitors: TEI-6720 and allopurinol in rats
    • Horiuchi H, Ota M, Kobayashi M et al. A comparative study on the hypouricemic activity and potency in renal xanthine calculus formation of two xanthine oxidase/xanthine dehydrogenase inhibitors: TEI-6720 and allopurinol in rats. Res Commun Mol Pathol Pharmacol 1999;104:307-19.
    • (1999) Res Commun Mol Pathol Pharmacol , vol.104 , pp. 307-319
    • Horiuchi, H.1    Ota, M.2    Kobayashi, M.3
  • 7
    • 13444257733 scopus 로고    scopus 로고
    • Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
    • Takano Y, Hase-Aoki K, Horiuchi H et al. Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Life Sci 2005;76:1835-47.
    • (2005) Life Sci , vol.76 , pp. 1835-1847
    • Takano, Y.1    Hase-Aoki, K.2    Horiuchi, H.3
  • 8
    • 65849179931 scopus 로고    scopus 로고
    • Adenuric Summary of Product Characteristics accessed at http://www.emea.europa.eu/humandocs/PDFs/EPAR/adenuric/H-777-PI-en.pdf, (date last accessed 8th April 2009).
    • Adenuric Summary of Product Characteristics accessed at http://www.emea.europa.eu/humandocs/PDFs/EPAR/adenuric/H-777-PI-en.pdf, (date last accessed 8th April 2009).
  • 9
    • 39849107900 scopus 로고    scopus 로고
    • Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects
    • Khosravan R, Grabowski B, Wu JT, Joseph-Ridge N, Vernillet L. Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects. Br J Clin Pharmacol 2008;65:355-63.
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 355-363
    • Khosravan, R.1    Grabowski, B.2    Wu, J.T.3    Joseph-Ridge, N.4    Vernillet, L.5
  • 10
    • 29644447615 scopus 로고    scopus 로고
    • The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
    • Khosravan R, Grabowski BA, Mayer MD, Wu JT, Joseph-Ridge N, Vemillet L. The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase. J Clin Pharmacol 2006;46:88-102.
    • (2006) J Clin Pharmacol , vol.46 , pp. 88-102
    • Khosravan, R.1    Grabowski, B.A.2    Mayer, M.D.3    Wu, J.T.4    Joseph-Ridge, N.5    Vemillet, L.6
  • 11
    • 17144396355 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment
    • Mayer MD, Khosravan R, Vernillet L, Wu JT, Joseph-Ridge N, Mulford DJ. Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment. Am J Ther 2005; 12:22-34.
    • (2005) Am J Ther , vol.12 , pp. 22-34
    • Mayer, M.D.1    Khosravan, R.2    Vernillet, L.3    Wu, J.T.4    Joseph-Ridge, N.5    Mulford, D.J.6
  • 12
    • 49649094011 scopus 로고    scopus 로고
    • The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
    • Khosravan R, Kukulka MJ, Wu JT, Joseph-Ridge N, Vernillet L. The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase. J Clin Pharmacol 2008;48:1014-24.
    • (2008) J Clin Pharmacol , vol.48 , pp. 1014-1024
    • Khosravan, R.1    Kukulka, M.J.2    Wu, J.T.3    Joseph-Ridge, N.4    Vernillet, L.5
  • 13
    • 14944345365 scopus 로고    scopus 로고
    • Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: A twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with grout
    • Becker MA, Schumacher HR Jr, Wortmann RL et al. Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: A twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with grout. Arthritis Rheum 2005;52:916-23.
    • (2005) Arthritis Rheum , vol.52 , pp. 916-923
    • Becker, M.A.1    Schumacher Jr, H.R.2    Wortmann, R.L.3
  • 14
    • 56049101851 scopus 로고    scopus 로고
    • Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28-week, phase III, randomized, double-blind, parallel-group trial
    • Schumacher HR Jr, Becker MA, Wortmann RL et al. Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28-week, phase III, randomized, double-blind, parallel-group trial. Arthritis Rheum 2008;59:1540-8.
    • (2008) Arthritis Rheum , vol.59 , pp. 1540-1548
    • Schumacher Jr, H.R.1    Becker, M.A.2    Wortmann, R.L.3
  • 16
    • 65849171996 scopus 로고    scopus 로고
    • Febuxostat versus allopurinol in the treatment of gout in subjects 65 years of age or older. Abstract
    • presented at the, Barcelona, Spain, 13-16 June, Abstract No. THU0353
    • Schumacher HR, Becker MA, MacDonald PA. Febuxostat versus allopurinol in the treatment of gout in subjects 65 years of age or older. Abstract presented at the Annual European Congress of Rheumatology (EULAR), Barcelona, Spain, 13-16 June 2007. [Abstract No. THU0353].
    • (2007) Annual European Congress of Rheumatology (EULAR)
    • Schumacher, H.R.1    Becker, M.A.2    MacDonald, P.A.3
  • 17
    • 65849497539 scopus 로고    scopus 로고
    • The FOCUS trial 48-month interim analysis: Long-term clinical outcomes of treatment with febuxostat in subjects with gout in an ongoing phase 2, open-label extension study. Abstract
    • presented at the, Amsterdam, the Netherlands, 21-24 June, Abstract No. OP0130
    • Schumacher H, Becker M, Wortmann R, Lloyd E, MacDonald P, Joseph-Ridge N. The FOCUS trial 48-month interim analysis: Long-term clinical outcomes of treatment with febuxostat in subjects with gout in an ongoing phase 2, open-label extension study. Abstract presented at the Annual European Congress of Rheumatology (EULAR), Amsterdam, the Netherlands, 21-24 June 2006. [Abstract No. OP0130].
    • (2006) Annual European Congress of Rheumatology (EULAR)
    • Schumacher, H.1    Becker, M.2    Wortmann, R.3    Lloyd, E.4    MacDonald, P.5    Joseph-Ridge, N.6
  • 18
    • 65849098008 scopus 로고    scopus 로고
    • The long-term stability of renal function in hyperuricemic subjects with gout treated with febuxostat. Abstract
    • presented at the, San Francisco, CA, USA, 31 October-5 November, Abstract No. SA-PO918
    • Whelton A, MacDonald P, Lloyd E. The long-term stability of renal function in hyperuricemic subjects with gout treated with febuxostat. Abstract presented at the American Society of Nephrology (ASN) Annual Meeting, San Francisco, CA, USA, 31 October-5 November 2007. [Abstract No. SA-PO918].
    • (2007) American Society of Nephrology (ASN) Annual Meeting
    • Whelton, A.1    MacDonald, P.2    Lloyd, E.3
  • 20
    • 84930164201 scopus 로고    scopus 로고
    • Urate-lowering therapy in subjects with gout: Interim results from the febuxostat comparative extension long-term study (EXCEL). Abstract
    • presented at the, Barcelona, Spain, 13-16 June, Abstract No. THU0339
    • Becker M, Schumacher H, MacDonald PA. Urate-lowering therapy in subjects with gout: Interim results from the febuxostat comparative extension long-term study (EXCEL). Abstract presented at the Annual European Congress of Rheumatology (EULAR), Barcelona, Spain, 13-16 June 2007. [Abstract No. THU0339].
    • (2007) Annual European Congress of Rheumatology (EULAR)
    • Becker, M.1    Schumacher, H.2    MacDonald, P.A.3
  • 21
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of ant platelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration
    • Collaborative overview of randomised trials of ant platelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. Br Med J 1994; 308:81-106.
    • (1994) Br Med J , vol.308 , pp. 81-106
  • 22
    • 34548142983 scopus 로고    scopus 로고
    • Independent impact of gout on mortality and risk for coronary heart disease
    • Choi HK, Curhan G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation 2007;116:894-900.
    • (2007) Circulation , vol.116 , pp. 894-900
    • Choi, H.K.1    Curhan, G.2
  • 25
  • 26
    • 34547489857 scopus 로고    scopus 로고
    • Uric acid reduction: A new paradigm in the management of cardiovascular risk?
    • Dawson J, Quinn T, Walters M. Uric acid reduction: A new paradigm in the management of cardiovascular risk? Curr Med Chem 2007;14:1879-86.
    • (2007) Curr Med Chem , vol.14 , pp. 1879-1886
    • Dawson, J.1    Quinn, T.2    Walters, M.3
  • 27
    • 23244462442 scopus 로고    scopus 로고
    • Serum uric acid and cardiovascular disease: Recent developments, and where do they leave us?
    • Baker JF, Krishnan E, Chen L, Schumacher HR. Serum uric acid and cardiovascular disease: Recent developments, and where do they leave us? Am J Med 2005;118: 816-26.
    • (2005) Am J Med , vol.118 , pp. 816-826
    • Baker, J.F.1    Krishnan, E.2    Chen, L.3    Schumacher, H.R.4
  • 28
    • 3242785541 scopus 로고    scopus 로고
    • Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: A prospective cohort study
    • Niskanen LK, Laaksonen DE, Nyyssonen K et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: A prospective cohort study. Arch Intern Med 2004;164:1546-51.
    • (2004) Arch Intern Med , vol.164 , pp. 1546-1551
    • Niskanen, L.K.1    Laaksonen, D.E.2    Nyyssonen, K.3
  • 29
    • 33745144316 scopus 로고    scopus 로고
    • Uric acid is a risk factor for myocardial infarction and stroke: The Rotterdam study
    • Bos MJ, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM. Uric acid is a risk factor for myocardial infarction and stroke: The Rotterdam study. Stroke 2006; 37:1503-7.
    • (2006) Stroke , vol.37 , pp. 1503-1507
    • Bos, M.J.1    Koudstaal, P.J.2    Hofman, A.3    Witteman, J.C.4    Breteler, M.M.5
  • 30
    • 40349089500 scopus 로고    scopus 로고
    • Hyperuricemia, gout and the metabolic syndrome
    • Puig JG, Martinez MA. Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol 2008;20:187-91.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 187-191
    • Puig, J.G.1    Martinez, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.