Syncope from dynamic left ventricular outflow tract obstruction: Simulating hypertrophic cardiomyopathy in a patient with primary AL-type amyloid heart disease

Texas Heart Institute Journal

Volumn 36, Issue 1, 2009, Pages 50-54

  Velazquez Ceceña, José Luis E ^a,b   Lubell, David L ^a   Nagajothi, Nagapradeep ^a   Al Masri, Hytham ^a   Siddiqui, Mumtaz ^a   Khosla, Sandeep ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b MOUNT SINAI HOSPITAL   (United States)

Author keywords

Amyloidosis classification diagnosis etiology mortality pathology therapy; Cardiomyopathies complications diagnosis; Cardiomyopathy, hypertrophic diagnosis; Diagnosis, differential; Echocardiography; Heart failure etiology; Prognosis; Syncope etiology physiopathology; Ventricular outflow obstruction etiology

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

AGED; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; DOPPLER ECHOCARDIOGRAPHY; ESSENTIAL HYPERTENSION; FEMALE; HEART AMYLOIDOSIS; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART MUSCLE BIOPSY; HUMAN; HUMAN TISSUE; HYPERTROPHIC CARDIOMYOPATHY; LABORATORY TEST; LOW DRUG DOSE; PHYSICAL EXAMINATION; SYNCOPE; TREATMENT OUTCOME;

AGED; AMYLOIDOSIS; BIOPSY; CARDIOMYOPATHY, HYPERTROPHIC; DIAGNOSIS, DIFFERENTIAL; ECHOCARDIOGRAPHY, DOPPLER, COLOR; ELECTROCARDIOGRAPHY; FATAL OUTCOME; FEMALE; HEART DISEASES; HUMANS; MYOCARDIUM; SYNCOPE; VENTRICULAR OUTFLOW OBSTRUCTION;

EID: 65749114621     PISSN: 07302347     EISSN: 15266702     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med 1997;337(13):898-909.
2. Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin Hematol 1995;32(1):45-59.
3. Falk RH, Plehn JF, Deering T, Schick EC Jr, Boinay P, Rubinow A, et al. Sensitivity and specificity of the echocardiographic features of cardiac amyloidosis. Am J Cardiol 1987;59(5):418-422
4. Oh JK. Cardiac diseases due to systemic illness, genetics, medication, or infection. In: Oh JK, Seward JB, Tajik AJ, editors. The echo manual. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 274-276
5. Siqueira-Filho AG, Cunha CL, Tajik AJ, Seward JB, Schattenberg TT, Giuliani ER. M-mode and two-dimensional echocardiographic features in cardiac amyloidosis. Circulation 1981;63(1):188-196
6. Morner S, Hellman U, Suhr OB, Kazzam E, Waldenstrom A. Amyloid heart disease mimicking hypertrophic cardiomyopathy. J Intern Med 2005;258(3):225-230
7. Dubrey SW, Cha K, Anderson J, Chamarthi B, Reisinger J, Skinner M, Falk RH. The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement. QJM 1998;91(2):141-157
8. Sedlis SP, Saffitz JE, Schwob VS, Jaffe AS. Cardiac amyloidosis simulating hypertrophic cardiomyopathy. Am J Cardiol 1984;53(7):969-970
9. Presti CF, Waller BF, Armstrong WF. Cardiac amyloidosis mimicking the echocardiographic appearance of obstructive hypertrophic myopathy. Chest 1988;93(4):881-883
10. Oh JK, Tajik AJ, Edwards WD, Bresnahan JF, Kyle RA. Dynamic left ventricular outflow tract obstruction in cardiac amyloidosis detected by continuous-wave Doppler echocardiography. Am J Cardiol 1987;59(9):1008-1010
11. Griffiths BE, Hughes P, Dowdle R, Stephens MR. Cardiac amyloidosis with asymmetrical septal hypertrophy and deterioration after nifedipine. Thorax 1982;37(9):711-712
12. Falk RH. Diagnosis and management of the cardiac amyloidoses. Circulation 2005;112(13):2047-2060
13. Liao R, Jain M, Teller P, Connors LH, Ngoy S, Skinner M, et al. Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfunction in isolated mouse hearts. Circulation 2001;104(14):1594-1597
14. Olson LJ, Gertz MA, Edwards WD, Li CY, Pellikka PA, Holmes DR Jr, et al. Senile cardiac amyloidosis with myocardial dysfunction. Diagnosis by endomyocardial biopsy and immunohistochemistry. N Engl J Med 1987;317(12):738-742
15. Colucci WS, Lorell BH, Schoen FJ, Warhol MJ, Grossman W. Hypertrophic obstructive cardiomyopathy due to Fabry's disease. N Engl J Med 1982;307(15):926-928
16. Monserrat L, Gimeno-Blanes JR, Marin F, Hermida-Prieto M, Garcia-Honrubia A, Perez I, et al. Prevalence of fabry disease in a cohort of 508 unrelated patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 2007;50(25):2399-2403
17. Weston LT, Raybuck BD, Robinowitz M, Brinker JA, Oetgen WJ. Primary amyloid heart disease presenting as hypertrophic obstructive cardiomyopathy. Cathet Cardiovasc Diagn 1986;12(3):176-181
18. Kyle RA, Spittell PC, Gertz MA, Li CY, Edwards WD, Olson LJ, Thibodeau SN. The premortem recognition of systemic senile amyloidosis with cardiac involvement. Am J Med 1996;101(4):395-400.
19. Dubrey SW, Cha K, Skinner M, LaValley M, Falk RH. Familial and primary (AL) cardiac amyloidosis: echocardiographically similar diseases with distinctly different clinical outcomes. Heart 1997;78(1):74-82.
20. Chamarthi B, Dubrey SW, Cha K, Skinner M, Falk RH. Features and prognosis of exertional syncope in light-chain associated AL cardiac amyloidosis. Am J Cardiol 1997;80(9):1242-1245
21. Mookadam F, Haley JH, Olson LJ, Cikes M, Mookadam M. Dynamic left ventricular outflow tract obstruction in senile cardiac amyloidosis. Eur J Echocardiogr 2006;7(6):465-468