The role of adjuvant radiation in endometrial cancer

ONCOLOGY

Volumn 23, Issue 4, 2009, Pages 342-349

  Diavolitsis, Virginia ^a   Boyle, John ^a   Singh, Diljeet K ^a   Small Jr , William ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Feinberg School of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CISPLATIN; GEMCITABINE; NAVELBINE; PACLITAXEL; UFT;

ABDOMINAL HYSTERECTOMY; ARTICLE; BRACHYTHERAPY; CANCER ADJUVANT THERAPY; CANCER INVASION; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; DISTANT METASTASIS; ENDOMETRIUM CANCER; EXTERNAL BEAM RADIOTHERAPY; GASTROINTESTINAL TOXICITY; GYNECOLOGIC SURGERY; HIGH RISK PATIENT; HUMAN; LIVER METASTASIS; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RECURRENCE RISK; RISK FACTOR; SALPINGOOOPHORECTOMY; SKIN TOXICITY; TUMOR VOLUME;

CHEMOTHERAPY, ADJUVANT; ENDOMETRIAL NEOPLASMS; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; HYSTERECTOMY; NEOPLASM STAGING; OVARIECTOMY; PATIENT SELECTION; RADIOTHERAPY, ADJUVANT; RECURRENCE; RISK ASSESSMENT; TREATMENT OUTCOME;

EID: 65749112529     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2008. CA Cancer J Clin 58:71-96, 2008.
2. Ries LAG, Melbert D, Krapcho M, et al: SEER cancer statistics review, 1975-2005. Bethesda, Md; National Cancer Institute. Available at http://seer.cancer.gov/csr/1975_2005/ (based on Nov 2007 SEER data submission), posted 2008.
3. Purdie DM, Green AC: Epidemiology of endometrial cancer. Best Pract Res Clin Obstet Gynecol 15:341-354, 2001.
4. Morrow CP, Bundy BN, Kurman RJ, et al: Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: A Gynecologic Oncology Group study. Gynecol Oncol 40:55-65, 1991.
5. Eifel PJ, Ross J, Hendrickson M, et al: Adenocarcinoma of the endometrium: Analysis of 256 cases with disease limited to the uterine corpus - treatment comparisons. Cancer 52:1026-1031, 1983.
6. Price L, Hohr GA, Rominjor DJ: Vaginal involvement in endometrial carcinoma. Am J Obstet Gynecol 191: 1060, 1965.
7. Keys HM, Roberts JA, Brunetto VL, et al: A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: A Gynecologic Oncology Group study. Gynecol Oncol 92:744-751, 2004.
8. Orr JW Jr, Holman JL, Orr PF: Stage I corpus cancer: Is teletherapy necessary? Am J Obstet Gynecol 176:777-789, 1997.
9. Straughn JM Jr, Huh WK, Kelly FJ, et al: Conservative management of stage I endometrial carcinoma after surgical staging. Gynecol Oncol 84:194-200, 2002.
10. National Comprehensive Cancer Network: NCCN clinical practice guidelines in oncology: Uterine neoplasms, version 1.2008. Available at www.nccn.org. Accessed Sept 1, 2008.
11. Zaino RJ, Kurman RJ, Diana KL, et al: Pathologic models to predict outcome for women with endometrial adenocarcinoma. Cancer 77:1115-1121, 1996.
12. Lurain JR, Rice BL, Rademaker AW, et al: Prognostic factors associated with recurrence in clinical stage I adenocarcinoma of the endometrium. Obstet Gynecol 78:63-69, 1991.
13. Abeler VM, Kjorstad KE, Berle E: Carcinoma of the endometrium in Norway: A histopathological and prognostic survey of a total population. Int J Gynecologic Cancer 2:9-32, 1992.
14. Schink JC, Lurain JR, Wallermark CB, et al: Tumor size in endometrial cancer: a prognostic factor for lymph node metastasis. Obstet Gynecol 70:216-219, 1987.
15. Aalders J, Abeler V, Kolstad P, et al: Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: Clinical and histopathologic study of 540 patients. Obstet Gynecol 56:419-427, 1980.
16. Creutzberg CL, van Putten WL, Koper PC, et al: Surgery and postoperative radiotherapy versus surgery alone for patients with stage I endometrial carcinoma: Multicentre randomized trial. Lancet 355:1404-1411, 2000.
17. Scholten AN, van Putten WL, Beerman H, et al: Postoperative radiotherapy for stage 1 endometrial carcinoma: Long-term outcome of the randomized PORTEC trial with central pathology review. Int J Radiat Oncol Biol Phys 63:834-838, 2005.
18. Creutzberg CL, van Putten WL, Koper PC, et al: The morbidity of treatment for patients with stage I endometrial cancer: Results from a randomized trial. Int J Radiat Oncol Biol Phys 51:1246-1255, 2001.
19. The ASTEC/EN.5 writing committee on behalf of the ASTEC/EN.5 Study Group: Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): Pooled trial results, systematic review, and meta-analysis. Lancet 373:137-146, 2009.
20. Lee CM, Szabo A, Shrieve DC, et al: Frequency and effect of adjuvant radiation therapy among women with stage I endometrial adenocarcinoma. JAMA 295:389-397, 2006.
21. Chadha M, Nanavati PJ, Liu P, et al: Patterns of failure in endometrial carcinoma stage IB grade 3 and IC patients treated with postoperative vaginal vault brachytherapy. Gynecol Oncol 75:103-107, 1999.
22. Pearcy R, Petereit D: Post-operative high dose rate brachytherapy in patients with low to intermediate risk endometrial cancer. Radiother Oncol 56:17-22, 2000.
23. Anderson JM, Stea B, Hallum AV, et al: High-dose rate postoperative vaginal cuff irradiation alone for stage IB and IC endometrial cancer. Int J Radiat Oncol Biol Phys 46:417-425, 2000.
24. Eltabb akh GH, Piver MS, Hempling RE, et al: Excellent long-term survival and absence of vaginal recurrences in 332 patients with low-risk stage I endometrial adenocarcinoma treated with hysterectomy and vaginal brachytherapy without formal staging lymph node sampling: Report of a prospective trial. Int J Radiat Oncol Biol Phys 38:373-380, 1997.
25. Nori D, Merimsky O, Batata M, et al: Postoperative high dose-rate intravaginal brachytherapy combined with external irradiation for early stage endometrial cancer: A long-term follow-up. Int J Radiat Oncol Biol Phys 30:831-837, 1994.
26. Jolly S, Vargas C, Kumar T, et al: Vaginal brachytherapy alone: An alternative to adjuvant whole pelvis radiation for early stage endometrial cancer. Gynecol Oncol 97:887-892, 2005.
27. Solhjem MC, Petersen IA, Haddock MG: Vaginal cuff HDR brachytherapy alone is sufficient adjuvant treatment for patients with surgical stage I endometrial cancer. Int J Radiat Oncol Biol Phys 62:1379-1384, 2005.
28. Petereit DG, Tannehill SP, Grosen EA, et al: Outpatient vaginal cuff brachytherapy for endometrial cancer. Int J Gynecol Cancer 9:456-462, 1999.
29. Diavolitsis VM, Lurain J, Schink J, et al: An analysis of clinical outcomes in patients with stage IB endometrial cancer treated with vaginal brachytherapy only. Proceedings of the American Brachytherapy Society Annual Meeting, Chicago, Apr 29-May 1, 2007.
30. Nout RA, Putter H, Jurgenliemk-Schulz IM et al: Vaginal brachytherapy versus external beam pelvic radiotherapy for high-intermediate risk endometrial cancer: Results of the randomized PORTEC-2 trial. J Clin Oncol 26, 2008.
31. Kuten A, Grigsby PW, Perez CA, et al: Results of radiotherapy in recurrent endometrial carcinoma: A retrospective analysis of 51 patients. Int J Radiat Oncol Biol Phys 17:29-34, 1989.
32. Jereczek-Fossa B, Badzio A, et al: Recurrent endometrial cancer after surgery alone: results of salvage radiotherapy. Int J Radiat Oncol Biol Phys 48:405-413, 2000.
33. Curran WJ, Whittington R, Peters AJ, et al: Vaginal recurrences of endometrial carcinoma: The prognostic value of staging by a primary vaginal carcinoma system. Int J Radiat Oncol Biol Phys 15:803-808, 1988.
34. Hoekstra CJ, Koper PC, van Putten WL: Recurrent endometrial adenocarcinoma after surgery alone: Prognostic factors and treatment. Radiother Oncol 27:164-166, 1993.
35. Sears JD, Greven KM, Hoen HM, et al: Prognostic factors and treatment outcome for patients with locally recurrent endometrial cancer. Cancer 74:1303-1308, 1994.
36. Hart KB, Han I, Shamsa F, et al: Radiation therapy for endometrial cancer in patients treated for postoperative recurrence. Int J Radiat Oncol Biol Phys 41:7-11, 1998.
37. Wylie J, Irwin C, Pintilie M, et al: Results of radical radiotherapy for recurrent endometrial cancer. Gynecol Oncol 77:66-72, 2000.
38. Lin LL, Grigsby PW, Powell MA, et al: Definitive radiotherapy in the management of isolated vaginal recurrences of endometrial cancer. Int J Radiat Oncol Biol Phys 63:500-504, 2005.
39. Creutzberg CL, van Putten WL, Koper PC, et al: M. PORTEC Study Group. Survival after relapse in patients with endometrial cancer: Results from a randomized trial. Gynecol Oncol 89:201-209, 2003.
40. Jhingran A, Burke T, Eifel P: Definitive radiotherapy for patients with isolated vaginal recurrence of endometrial carcinoma after hysterectomy. Int J Radiat Oncol Biol Phys 56:1366-1372, 2003.
41. Petignat P, Jolicoeur M, Alobaid A, et al: Salvage treatment with high-dose-rate brachy-therapy for isolated vaginal endometrial cancer recurrcnce. Gynecol Oncol 101:445-449, 2006.
42. Ayhan A, Taskiran C, Celik C, et al: Surgical stage III endometrial cancer: analysis of treatment outcomes, prognostic factors and failure patterns. Eur J Gynaecol Oncol 23:553-556, 2002.
43. Mundt AJ, McBride R, Rotmensch J, et al: Significant pelvic recurrence in high-risk pathologic stage I-IV endometrial carcinoma patients after adjuvant chemotherapy alone: Implications for adjuvant radiation therapy. Int J Radiat Oncol Biol Phys 50:1145-1153, 2001.
44. Randall ME, Filiaci VL, Muss H, et al: Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: A Gynecologic Oncology Group study. J Clin Oncol 24: 36-44, 2006.
45. Patel S, Portelance L, Gilbert L, et al: Analysis of prognostic factors and patterns of recurrence in patients with pathologic stage III endometrial cancer. Int J Radiat Oncol Biol Phys 68:1438-1445, 2007.
46. Potish RA, Twiggs LB, Adcock LL, et al: Paraaortic lymph node radiotherapy in cancer of the uterine corpus. Obstet Gynecol 65:251-256, 1985.
47. Delclos L, Fletcher GH, Gutierrez AG, et al: Adenocarcinoma of the uterus. Am J Roentgenol 103:603-608, 1969.
48. Rose PG, Cha SD, Tak WK, et al: Radiation therapy for surgically proven para-aortic node metastasis in endometrial carcinoma. Int J Radiat Oncol Biol Phys 24:229-233, 1992.
49. Smith RS, Kapp DS, Chen Q, et al: Treatment of high-risk uterine cancer with whole abdominopelvic radiation therapy. Int J Radiat Oncol Biol Phys 48:767-778, 2000.
50. Small W, Mahadevan A, Roland P, et al: Whole-abdominal radiation in endometrial carcinoma: An analysis of toxicity, patterns of recurrence, and survival. Cancer J 6:394-400, 2000.
51. Greven K, Winter K, Underhill K, et al: Final analysis of RTOG 9708: Adjuvant postoperative irradiation combined with cisplatin/paclitaxel chemotherapy following surgery for patients with high-risk endometrial cancer. Gynecol Oncol 103:155-159, 2006.
52. Hogberg P, Rosenberg G, Kristensen CF, et al: A randomized phase-III study on adjuvant treatment with radiation (RT) ± chemotherapy (CT) in early-stage high-risk endometrial cancer (NSGO-EC-9501/EORTC 55991) (abstract 5503). J Clin Oncol 25(18S):274s, 2007.
53. American Cancer Society: Cancer Facts & Figures 2008. Available at www.cancer.org. Accessed Sept 9, 2008.
54. Ashman JB, Connell PP, Yamada D, et al: Outcome of endometrial carcinoma patients with involvement of the uterine serosa. Gynecol Oncol 82:338-343, 2001.