Fatal liver failure in a patient on acetaminophen treated with sunitinib malate and levothyroxine

Annals of Pharmacotherapy

Volumn 43, Issue 4, 2009, Pages 761-766

  Weise, Amy M ^a,b   Liu, Chin Y ^a   Shields, Anthony F ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b KARMANOS CANCER INSTITUTE   (United States)

Author keywords

Acetaminophen; Hepatotoxicity; Levothyroxine; Sunitinib

Indexed keywords

IMATINIB; LEVOTHYROXINE; LIVER ENZYME; PARACETAMOL; SUNITINIB;

ADULT; ALOPECIA; ANAMNESIS; APPETITE DISORDER; ARTICLE; AUTOPSY; BLOOD CELL COUNT; BURNING SENSATION; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE INCREASE; DRUG ERUPTION; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; EDEMA; FATIGUE; FEMALE; GASTROINTESTINAL STROMAL TUMOR; HEADACHE; HUMAN; HYPOTHYROIDISM; LIVER FAILURE; LIVER FUNCTION; METASTASIS; MULTIPLE CYCLE TREATMENT; PERIORBITAL EDEMA; PRIORITY JOURNAL; TASTE DISORDER; TONGUE BURNING SENSATION;

ACETAMINOPHEN; DRUG THERAPY, COMBINATION; FATAL OUTCOME; FEMALE; HUMANS; INDOLES; LIVER FAILURE; MIDDLE AGED; PYRROLES; THYROXINE;

EID: 65749099372     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1L528     Document Type: Article

References (18)

1. Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003;9:327-337
2. Package insert. Sutent (sunitinib malate). New York, NY: Pfizer Inc., issued 2006, revised May 2008.
3. Cabebe E, Wakelee H. Sunitinib: a newly approved small-molecule inhibitor of angiogenesis. Drugs Today (Barc) 2006;42:387-398 (Pubitemid 44090113)
4. Krawitt EL. Autoimmune hepatitis. N Engl J Med 2006;354:54-66. (Pubitemid 43048951)
5. Goodman VL, Rock EP, Dagher R, et al. Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal carcinoma. Clin Cancer Res 2007;13:1367-1373
6. Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006;368:1329-1338
7. Desai J, Yassa L, Marqusee E, et al. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med 2006;145:660-664
8. Rini BI, Tamaskar I, Shaheen P, et al. Hypothyroidism in patients with metastatic renal carcinoma treated with sunitinib. J Natl Cancer Inst 2007;99:81-83
9. Package insert. Gleevec (imatinib mesylate). East Hanover, NJ: Novartis Pharmaceuticals Corp., issued 2001, revised September 2008.
10. Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005;42:1364-1372 DOI 10.1002/hep.20948 (Pubitemid 43260039)
11. Jaeschke H, Bajt ML. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 2006;89:31-41. (Pubitemid 43013752)
12. Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994;272:1845-1850.
13. Slattery JT, Wilson JM, Kalhorn TF, Nelson SD. Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. Clin Pharmacol Ther 1987;41:413-418 (Pubitemid 17058926)
14. Bruck R, Frenkel D, Shirin H, et al. Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. Dig Dis Sci 1999;44:1228-1235
15. Jia Y, Guo GL, Surapureddi S, et al. Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proc Natl Acad Sci U S A 2005;102:12531-12536
16. Hartleb M. Do thyroid hormones promote hepatotoxicity to acetaminophen? Am J Gastroenterol 1994;89:1269-1270
17. Upadhyay G, Singh R, Kumar A, Kumar S, Kapoor A, Godbole MM. Severe hyperthyroidism induces mitochondria-mediated apoptosis in rat liver. Hepatology 2004;39:1120-1130 (Pubitemid 38428951)
18. Danan G, Benichou C. Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993;46:1323-1330