Clock genes in health and diseases

Journal of Applied Biomedicine

Volumn 7, Issue 1, 2009, Pages 15-33

  Mongrain, Valérie ^a,b,c   Cermakian, Nicolas ^a,b  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Cancer; Circadian rhythms; Clock genes; Human; Metabolism; Peripheral clocks; Psychiatric disorders; Sleep disorders

Indexed keywords

PER1 PROTEIN; PER2 PROTEIN; PER3 PROTEIN; PROTEIN BMAL1; PROTEIN CKI EPSILON; PROTEIN CRYS; PROTEIN DBP; PROTEIN KINASE; PROTEIN NPAS2; PROTEIN REV ERB BETA; PROTEIN ROR ALPHA; PROTEIN ROR GAMMA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG;

AGING; BIPOLAR DISORDER; CARDIOVASCULAR DISEASE; CELL CYCLE; CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SLEEP DISORDER; DRUG DEPENDENCE; FERTILITY; GENE EXPRESSION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; HEALTH STATUS; HOMEOSTASIS; HUMAN; IMMUNITY; LIGHT DARK CYCLE; MALIGNANT NEOPLASTIC DISEASE; MENTAL HEALTH; METABOLIC DISORDER; NONHUMAN; PROTEIN PHOSPHORYLATION; PSYCHOPATHY; REGULATORY MECHANISM; REVIEW; SLEEP DISORDER; SLEEP TIME;

MAMMALIA;

EID: 65749098380     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.32725/jab.2009.002     Document Type: Review

References (210)

1. Abe M, Herzog ED, Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD: Circadian rhythms in isolated brain regions. J. Neurosci. 22:350-356, 2002.
2. Akashi M. Takumi T: The orphan nuclear receptor RORα regulated circadian transcription of the mammalian core-clock Bmal1. Nat. Struct. Mol. Biol. 12:441-448, 2005.
3. Akhisaroglu M, Ahmed R, Kurtuncu M, Manev H, Uz T: Diurnal rhythms in cocaine sensitization and in Period1 levels are common across rodent species. Pharmacol. Biochem. Behav. 79:37-42, 2004.
4. Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bućan M, Ahima RS, Kaestner KH, Lazar MA: Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 456:997-1000, 2008.
5. Alvarez JD, Hansen A, Ord T, Bebas P, Chappell PE, Giebultowicz JM, Williams C, Moss S, Sehgal A: The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice. J. Biol. Rhythms 23:26-36, 2008.
6. American Academy of Sleep Medicine (AASM): International Classification of Sleep Disorders, 2nd edn. Diagnostic and Coding Manual. American Academy of Sleep Medicine; Westchester 2005.
7. Andreas S, Eichele G: Sleep apnoea: time to consider clock genes. Eur. Respir. J. 32:1-2, 2008.
8. Angeles-Castellanos M, Salgado-Delgado R, Rodríguez K, Buijs RM, Escobar C: Expectancy for food or expectancy for chocolate reveals timing systems for metabolism and reward. Neuroscience 155:297-307, 2008.
9. Antoch MP, Gorbacheva VY, Vykhovanets O, Toshkov IA, Kondratov RV, Kondratova AA, Lee C, Nikitin AY: Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis. Cell Cycle 7:1197-1204, 2008.
10. Antoniadis EA, Ko CH, Ralph MR, McDonald RJ: Circadian rhythms, aging and memory. Behav. Brain Res. 114:221-233, 2000.
11. Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M: A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 26:413-415, 2003.
12. Arjona A, Sarkar DK: The circadian gene mPer2 regulates the daily rhythm of IFN-gamma. J. Interferon Cytokine Res. 26:645-649, 2006.
13. Azama T, Yano M, Oishi K, Kadota K, Hyun K, Tokura H, Nishimura S, Matsunaga T, Iwanaga H, Miki H, Okada K, Hiraoka N, Miyata H, Takiguchi S, Fujiwara Y, Yasuda T, Ishida N, Monden M: Altered expression profiles of clock genes hPer1 and hPer2 in peripheral blood mononuclear cells of cancer patients undergoing surgery. Life Sci. 80:1100-1108, 2007.
14. Barnard AR, Nolan PM: When clocks go bad: neurobehavioural consequences of disrupted circadian timing. PLoS Genet. 4:e1000040, 2008.
15. Berger J: Advances in chronohaematology. J. Appl. Biomed. 6:65-72, 2008.
16. Biggi N, Consonni D, Galluzzo V, Sogliani M, Costa G: Metabolic syndrome in permanent night workers. Chronobiol. Int. 25:443-454, 2008.
17. Boggild H, Knutsson A: Shift work, risk factors and cardiovascular disease. Scand. J. Work Environ. Health 25:85-99, 1999.
18. Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ: Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126:789-799, 2006.
19. Born J, Lange T, Hansen K, Mölle M, Fehm HL: Effects of sleep and circadian rhythm on human circulating immune cells. J. Immunol. 158:4454-4464, 1997.
20. Buja A, Mastrangelo G, Perissinotto E, Grigoletto F, Frigo AC, Rausa G, Marin V, Canova C, Dominici F: Cancer incidence among female flight attendants: a meta-analysis of published data. J. Womens Health (Larchmt) 15:98-105, 2006.
21. Burioka N, Koyanagi S, Endo M, Takata M, Fukuoka Y, Miyata M, Takeda K, Chikumi H, Ohdo S, Shimizu E: Clock gene dysfunction in patients with obstructive sleep apnoea syndrome. Eur. Respir. J. 32:105-112, 2008.
22. Cajochen C, Munch M, Knoblauch V, Blatter K, Wirz-Justice A: Age related changes in the circadian and homeostatic regulation of human sleep. Chronobiol. Int. 23:461-474, 2006.
23. Carpen JD, Archer SN, Skene DJ, Smits M, von Schantz M: A single-nucleotide polymorphism in the 5′-untranslated region of the hPER2 gene is associated with diurnal preference. J. Sleep Res. 14:293-297, 2005.
24. Carpen JD, von Schantz M, Smits M, Skene DJ, Archer SN: A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans. J. Hum. Genet. 51:1122-1125, 2006.
25. Cavadini G, Petrzilka S, Kohler P, Jud C, Tobler I, Birchler T, Fontana A: TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc. Natl. Acad. Sci. U.S.A. 104:12843-12848, 2007.
26. Cermakian N, Boivin DB: A molecular perspective of human circadian rhythm disorders. Brain Res. Rev. 42:204-220, 2003.
27. Cermakian N, Sassone-Corsi P: Environmental stimulus perception and control of circadian clocks. Curr. Opin. Neurobiol. 12:359-365, 2002.
28. Chen ST, Choo KB, Hou MF, Yeh KT, Kuo SJ, Chang JG: Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis 26:1241-1246, 2005.
29. Chen Z, McKnight SL: A conserved DNA damage response pathway responsible for coupling the cell division cycle to the circadian and metabolic cycles. Cell Cycle 6:2906-2912, 2007.
30. Copertaro A, Bracci M, Barbaresi M, Santarelli L: Assessment of cardiovascular risk in shift healthcare workers. Eur. J. Cardiovasc. Prev. Rehabil. 15:224-229, 2008.
31. Costa G: The impact of shift and night work on health. Appl. Ergon. 27:9-16, 1996.
32. Craig LA, McDonald RJ: Chronic disruption of circadian rhythms impairs hippocampal memory in the rat. Brain Res. Bull. 76:141-151, 2008.
33. Cutolo M, Seriolo B, Craviotto C, Pizzorni C, Sulli A: Circadian rhythms in RA. Ann. Rheum. Dis. 62:593-596, 2003.
34. Dagenais-Bellefeuille S, Bertomeu T, Morse D: S-phase and M-phase timing are under independent circadian control in the dinoflagellate Lingulodinium. J. Biol. Rhythms 23:400-408, 2008.
35. Damiola F, Le Minh N, Preitner N, Kornmann B, Fleury-Olela F, Schibler U: Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 14:2950-2961, 2000.
36. Dardente H, Cermakian N: Molecular circadian rhythms in central and peripheral clocks in mammals. Chronobiol Int. 24:195-213, 2007.
37. Dardente H, Fortier EE, Martineau V, Cermakian N: Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression. Biochem. J. 402:525-536, 2007.
38. Davidson AJ, Yamazaki S, Arble DM, Menaker M, Block GD: Resetting of central and peripheral circadian oscillators in aged rats. Neurobiol. Aging 29:471-477, 2008.
39. Davis S, Mirick DK, Stevens RG: Night shift work, light at night, and risk of breast cancer. J. Natl. Cancer Inst. 93:1557-1562, 2001.
40. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM: A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 50:465-477, 2006.
41. DeBruyne JP, Weaver DR, Reppert SM: CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat. Neurosci. 10:543-545, 2007.
42. Dolatshad H, Campbell EA, O'Hara L, Maywood ES, Hastings MH, Johnson MH: Developmental and reproductive performance in circadian mutant mice. Hum. Reprod. 21:68-79, 2006.
43. Dudley CA, Erbel-Sieler C, Estill SJ, Reick M, Franken P, Pitts S, McKnight SL: Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 301:379-383, 2003.
44. Duez H, Staels B: Rev-erb alpha gives a time cue to metabolism. FEBS Lett. 582:19-25, 2008.
45. Duez H, Veen JV, Duhem C, Pourcet B, Touvier T, Fontaine C, Derudas B, Baugé E, Havinga R, Bloks VW, Wolters H, van der Sluijs FH, Vennström B, Kuipers F, Staels B: Regulation of Bile Acid Synthesis by the Nuclear Receptor Reverbalpha. Gastroenterology 135:689-698 2008.
46. Duffield GE: DNA microarray analyses of circadian timing: the genomic basis of biological time. J. Neuroendocrinol. 15:991-1002, 2003.
47. Dunlap JC, Loros JJ, DeCoursey PJ: Chronobiology: Biological Timekeeping. Sinauer Associates, Sunderland 2004.
48. Durgan DJ, Trexler NA, Egbejimi O, McElfresh TA, Suk HY, Petterson LE, Shaw CA, Hardin PE, Bray MS, Chandler MP, Chow CW, Young ME: The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids. J. Biol. Chem. 281:24254-24269, 2006.
49. Eksik A, Akyol A, Norgaz T, Aksu H, Erdinler I, Cakmak N, Alper AT, Cinar B, Yildirim A, Gürkan K: Circadian pattern of spontaneous ventricular tachyarrhythmias in patients with implantable cardioverter defibrillators. Med. Sci. Monit. 13:CR412-416, 2007.
50. Ellingsen T, Bener A, Gehani AA: Study of shift work and risk of coronary events. J. R. Soc. Health 127:265-267, 2007.
51. Fekete M, van Ree JM, Niesink RJ, de Wied D: Disrupting circadian rhythms in rats induces retrograde amnesia. Physiol. Behav. 34:883-887, 1985.
52. Filipski E, King VM, Li X, Granda TG, Mormont MC, Liu X, Claustrat B, Hastings MH, Lévi F: Host circadian clock as a control point in tumor progression. J. Natl. Cancer Inst. 94:690-697, 2002.
53. Filipski E, King VM, Li X, Granda TG, Mormont MC, Claustrat B, Hastings MH, Lévi F: Disruption of circadian coordination accelerates malignant growth in mice. Pathol. Biol. (Paris) 51:216-219, 2003.
54. Filipski E, Delaunay F, King VM, Wu MW, Claustrat B, Gréchez-Cassiau A, Guettier C, Hastings MH, Francis L: Effects of chronic jet lag on tumor progression in mice. Cancer Res. 64:7879-7885, 2004.
55. Filipski E, Innominato PF, Wu M, Li XM, Iacobelli S, Xian LJ, Lévi F: Effects of light and food schedules on liver and tumor molecular clocks in mice. J. Natl. Cancer Inst. 97:507-517, 2005.
56. Fontaine C, Staels B: The orphan nuclear receptor Rev-erbα: a transcriptional link between circadian rhythmicity and cardiometabolic disease. Curr. Opin. Lipidol. 18:141-146, 2007.
57. Franken P, Dudley CA, Estill SJ, Barakat M, Thomason R, O'Hara BF, McKnight SL: NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc. Natl. Acad. Sci. U.S.A. 103:7118-7123, 2006.
58. Franken P, Thomason R, Heller HC, O'Hara BF: A non-circadian role for clock-genes in sleep homeostasis: a strain comparison. BMC Neurosci. 8:87, 2007.
59. Fu L, Pelicano H, Liu J, Huang P, Lee C: The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111:41-50, 2002.
60. Fu L, Patel MS, Bradley A, Wagner EF, Karsenty G: The molecular clock mediates leptin-regulated bone formation. Cell 122:803-815, 2005.
61. Gallego M, Kang H, Virshup DM: Protein phosphatase 1 regulates the stability of the circadian protein PER2. Biochem. J. 399:169-175, 2006.
62. Gallego M, Virshup DM: Post-translational modifications regulate the ticking of the circadian clock. Nat. Rev. Mol. Cell Biol. 8:139-148, 2007.
63. Gatfield D, Schibler U: Circadian glucose homeostasis requires compensatory interference between brain and liver clocks. Proc. Natl. Acad. Sci. U.S.A. 105:14753-14754, 2008.
64. Gauger MA, Sancar A: Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer. Cancer Res. 65:6828-6834, 2005.
65. Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ: Role of the CLOCK protein in the mammalian circaidian mechanism. Science 280:1564-1569, 1998.
66. Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP: The circadian gene Per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol. Cell 22:375-382, 2006.
67. Gomez-Abellán P, Hernández-Morante JJ, Luján JA, Madrid JA, Garaulet M: Clock genes are implicated in the human metabolic syndrome. Int. J. Obes. (Lond.) 32:121-128, 2008.
68. Gorbacheva VY, Kondratov RV, Zhang R, Cherukuri S, Gudkov AV, Takahashi JS, Antoch MP: Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc. Natl. Acad. Sci. U.S.A. 102:3407-3412, 2005.
69. Granados-Fuentes D, Saxena MT, Prolo LM, Aton SJ, Herzog ED: Olfactory bulb neurons express functional, entrainable circadian rhythms. Eur. J. Neurosci. 19:898-906, 2004.
70. Granda TG, Liu XH, Smaaland R, Cermakian N, Filipski E, Sassone-Corsi P, Lévi F: Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor. FASEB J. 19:304-306, 2005.
71. Gréchez-Cassiau A, Panda S, Lacoche S, Teboul M, Azmi S, Laudet V, Hogenesch JB, Taneja R, Delaunay F: The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. J. Biol. Chem. 279:1141-1150, 2004.
72. CIP1 expression and hepatocyte proliferation. J. Biol. Chem. 283:4535-4542, 2008.
73. Guillaumond F, Dardente H, Giguere V, Cermakian N: Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J. Biol. Rhythms 20:391-403, 2005.
74. Hamaguchi H, Fujimoto K, Kawamoto T, Noshiro M, Maemura K, Takeda N, Nagai R, Furukawa M, Honma S, Honma K, Kurihara H, Kato Y: Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem. J. 382:43-50, 2004.
75. Hampp G, Ripperger JA, Houben T, Schmutz I, Blex C, Perreau-Lenz S, Brunk I, Spanagel R, Ahnert-Hilger G, Meijer JH, Albrecht U: Regulation of monoamine oxidase a by circadian-clock components implies clock influence on mood. Curr. Biol. 18:678-683, 2008.
76. Hansen J: Light at night, shiftwork, and breast cancer risk. J. Natl. Cancer Inst. 93:1513-1515, 2001.
77. Harper DG, Stopa EG, Kuo-Leblanc V, McKee AC, Asayama K, Volicer L, Kowall N, Satlin A: Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain 131:1609-1617, 2008.
78. Hastings MH, Herzog ED: Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei. J. Biol. Rhythms. 19:400-413, 2004.
79. Haupt CM, Alte D, Dörr M, Robinson DM, Felix SB, John U, Völzke H: The relation of exposure to shift work with atherosclerosis and myocardial infarction in a general population. Atherosclerosis 201: 205-211, 2008.
80. Hayashi M, Shimba S, Tezuka M: Characterization of the molecular clock in mouse peritoneal macrophages. Biol. Pharm. Bull. 30:621-626, 2007.
81. Hoffman AE, Zheng T, Ba Y, Zhu Y: The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. Mol. Cancer Res. 6:1461-1468, 2008.
82. Holmbäck U, Forslund A, Forslund J, Hambraeus L, Lennernäs M, Lowden A, Stridsberg M, Akerstedt T: Metabolic responses to nocturnal eating in men are affected by sources of dietary energy. J. Nutr. 132:1892-1899, 2002.
83. Hriscu ML: Modulatory factors of circadian phagocytic activity. Ann. N. Y. Acad. Sci. 1057:403-430, 2005.
84. Inoue I, Shinoda Y, Ikeda M, Hayashi K, Kanazawa K, Nomura M, Matsunaga T, Xu H, Kawai S, Awata T, Komoda T, Katayama S: CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element. J. Atheroscler. Thromb. 12:169-174, 2005.
85. Iurisci I, Filipski E, Reinhardt J, Bach S, Gianella-Borradori A, Iacobelli S, Meijer L, Lévi F: Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor. Cancer Res. 66:10720-10728, 2006.
86. Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y, Shibui K, Kim K, Kudo Y, Katoh M, Watanabe T, Nakajima T, Ozeki Y, Sugishita M, Hori T, Ikeda M, Toyoshima R, Inoue Y, Yamada N, Mishima K, Nomura M, Ozaki N, Okawa M, Takahashi K, Yamauchi T: Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Psychiatry Res. 109:121-128, 2002.
87. Johansson C, Willeit M, Smedh C, Ekholm J, Paunio T, Kieseppá T, Lichtermann D, Praschak-Rieder N, Neumeister A, Nilsson LG, Kasper S, Peltonen L, Adolfsson R, Schalling M, Partonen T: Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology 28:734-739, 2003.
88. Jones KH, Ellis J, von Schantz M, Skene DJ, Dijk DJ, Archer SN: Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities. J. Sleep Res. 16:12-16, 2007.
89. Kang HS, Angers M, Beak JY, Wu X, Gimble JM, Wada T, Xie W, Collins JB, Grissom SF, Jetten AM: Gene expression profiling reveals a regulatory role for RORα and ROR in phase I and phase II metabolism. Physiol. Genomics 31:281-294, 2007.
90. Katzenberg D, Young T, Finn L, Lin L, King DP, Takahashi JS, Mignot E: A CLOCK polymorphism associated with human diurnal preference. Sleep 21:569-576, 1998.
91. Kawakami C, Ohshige K, Tochikubo O: Circadian variation in cardiovascular emergencies among the elderly. Clin. Exp. Hypertens. 30:23-31, 2008.
92. Kennaway DJ, Owens JA, Voultsios A, Boden MJ, Varcoe TJ: Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293:R1528-R1537, 2007.
93. Kloog I, Haim A, Stevens RG, Barchana M, Portnov BA: Light at night co-distributes with incident breast but not lung cancer in the female population of Israel. Chronobiol. Int. 25:65-81, 2008.
94. Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP: Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev. 20:1868-1873, 2006.
95. Kornmann B, Schaad O, Bujard H, Takahashi JS, Schibler U: System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol. 5:e34, 2007.
96. Kosobud AE, Gillman AG, Leffel JK 2nd, Pecoraro NC, Rebec GV, Timberlake W: Drugs of abuse can entrain circadian rhythms. ScientificWorldJournal 7:203-212, 2007.
97. Kudo T, Kawashima M, Tamagawa T, Shibata S: Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/ or cholic acid diet. Am. J. Physiol. Endocrinol. Metab. 294:E120-E130, 2008.
98. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193-205, 1999.
99. Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I: Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ. Res. 102:607-614, 2008.
100. Kurebayashi S, Ueda E, Sakaue M, Patel DD, Medvedev A, Zhang F, Jetten AM: Retinoid-related orphan receptor gamma (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl. Acad. Sci. U.S.A. 97:10132-10137, 2000.
101. Lamia KA, Storch KF, Weitz CJ: Physiological significance of a peripheral tissue circadian clock. Proc. Natl. Acad. Sci. U.S.A 105:15172-15177, 2008.
102. Lamont EW, Robinson B, Stewart J, Amir S: The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2. Proc. Natl. Acad. Sci. U.S.A. 102:4180-4184, 2005.
103. Lamont EW, Legault-Coutu D, Cermakian N, Boivin DB: The role of circadian clock genes in mental disorders. Dialogues Clin. Neurosci. 9:333-342, 2007.
104. Lau P, Nixon SJ, Parton RG, Muscat GE: RORα regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J. Biol. Chem. 279:36828-36840, 2004.
105. Lee CC: Tumor suppression by the mammalian Period genes. Cancer Causes Control. 17:525-530, 2006.
106. Lennernäs M, Akerstedt T, Hambraeus L: Nocturnal eating and serum cholesterol of three-shift workers. Scand. J. Work Environ. Health 20:401-406, 1994.
107. Lévi F, Filipski E, Iurisci I, Li XM, Innominato P: Cross-talks between circadian timing system and cell division cycle determine cancer biology and therapeutics. Cold Spring Harb. Symp. Quant. Biol. 72:465-475, 2007.
108. Lévi F, Altinok A, Clairambault J, Goldbeter A: Implications of circadian clocks for the rhythmic delivery of cancer therapeutics. Philos. Transact. A. Math. Phys. Eng. Sci. 366:3575-3598, 2008.
109. Liu J, Malkani G, Shi X, Meyer M, Cunningham-Runddles S, Ma X, Sun ZS: The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock. Infect. Immun. 74:4750-4756, 2006.
110. Liu AC, Welsh DK, Ko CH, Tran HG, Zhang EE, Priest AA, Buhr ED, Singer O, Meeker K, Verma IM, Doyle FJ 3rd, Takahashi JS, Kay SA: Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell 129:605-616, 2007a.
111. Liu C, Li S, Liu T, Borjigin J, Lin JD: Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 447:477-481, 2007b.
112. Lowrey PL, Takahashi JS: Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu. Rev. Genet. 34:533-562, 2000.
113. Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR: Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes. Brain Res. 1213:166-177, 2008.
114. Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ: Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization. Hypertension 49:1104-1113, 2007.
115. Martino TA, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph MR, Sole MJ: Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294:R1675-R1683, 2008.
116. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H: Control mechanism of the circadian clock for timing of cell division in vivo. Science 302:255-259, 2003.
117. McClung CA, Sidiropoulou K, Vitaterna M, Takahashi JS, White FJ, Cooper DC, Nestler EJ: Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc. Natl. Acad. Sci. U.S.A. 102:9377-9381, 2005.
118. McClung CA: Role for the Clock gene in bipolar disorder. Cold Spring Harb. Symp. Quant. Biol. 72:637-644, 2007a.
119. McClung CA: Circadian rhythms, the mesolimbic dopaminergic circuit, and drug addiction. ScientificWorldJournal 7:194-202, 2007b.
120. Méndez-Ferrer S, Lucas D, Battista M, Frenette PS: Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452:442-447, 2008.
121. Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NR, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, Boot-Handford RP, Hastings MH, Loudon AS: Setting clock speed in mammals: the CK1•• tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. Neuron 58:78-88, 2008.
122. Miller BH, Olson SL, Turek FW, Levine JE, Horton TH, Takahashi JS: Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy. Curr. Biol. 14:1367-1373, 2004.
123. Miller BH, Olson SL, Levine JE, Turek FW, Horton TH, Takahashi JS: Vasopressin regulation of the proestrous luteinizing hormone surge in wild-type and Clock mutant mice. Biol. Reprod. 75:778-784, 2006.
124. Miller BH, McDearmon EL, Panda S, Hayes KR, Zhang J, Andrews JL, Antoch MP, Walker JR, Esser KA, Hogenesch JB, Takahashi JS: Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 104:3342-3347, 2007.
125. Mongrain V, Ruan X, Dardente H, Fortier EE, Cermakian N: Clock-dependent and independent transcriptional control of the two isoforms from the mouse Rorγ gene. Genes Cells 13:1197-1210, 2008.
126. Mormont MC, Waterhouse J, Bleuzen P, Giacchetti S, Jami A, Bogdan A, Lellouch J, Misset JL, Touitou Y, Lévi F: Marked 24-h rest/ activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status. Clin. Cancer Res. 6:3038-3045, 2000.
127. Morse D, Cermakian N, Brancorsini S, Parvinen M, Sassone-corsi P: No circadian rhythms in testis: Period1 expression is Clock independent and developmentally regulated in the mouse. Mol. Endocrinol. 17:141-151, 2003.
128. Motzkus D, Albrecht U, Maronde E: The human PER1 gene is inducible by interleukin-6. J. Mol. Neurosci. 18:105-109, 2002.
129. Muller JE, Tofler GH, Willich SN, Stone PH: Circadian variation of cardiovascular disease and sympathetic activity. J. Cardiovasc. Pharmacol. 10:S104-S109, 1987.
130. Naito Y, Tsujino T, Kawasaki D, Okumura T, Morimoto S, Masai M, Sakoda T, Fujioka Y, Ohyanagi M, Iwasaki T: Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats. J. Hypertens. 21:1107-1115, 2003.
131. Nakahata Y, Akashi M, Trcka D, Yasuda A, Takumi T: The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks. BMC Mol. Biol. 7:5, 2006.
132. Nakamura K, Inoue I, Takahashi S, Komoda T, Katayama S: Cryptochrome and period proteins are regulated by the CLOCK/BMAL1 gene: crosstalk between the PPARs/RXRα-regulated and CLOCK/BMAL1-regulated systems. PPAR Res. 348610, 2008.
133. Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, Kohno N, Kato Y: DEC1 modulates the circadian phase of clock gene expression. Mol. Cell Biol. 28:4080-4092, 2008.
134. Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH, Turek FW: The circadian clock mutation alters sleep homeostasis in the mouse. J. Neurosci. 20:8138-8143, 2000.
135. Ohkura N, Oishi K, Sudo T, Hayashi H, Shikata K, Ishida N, Matsuda J, Horie S: CLOCK regulates circadian platelet activity. Thromb. Res. 123:523-527, 2008.
136. Oishi K, Shirai H, Ishida N: CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice. Biochem. J. 386:575-581, 2005.
137. Oishi K, Atsumi G, Sugiyama S, Kodomari I, Kasamatsu M, Machida K, Ishida N: Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice. FEBS Lett. 580:127-130, 2006.
138. Okada K, Yano M, Doki Y, Azama T, Iwanaga H, Miki H, Nakayama M, Miyata H, Takiguchi S, Fujiwara Y, Yasuda T, Ishida N, Monden M: Injection of LPS causes transient suppression of biological clock genes in rats. J. Surg. Res. 145:5-12, 2008.
139. Otálora BB, Madrid JA, Alvarez N, Vicente V, Rol MA: Effects of exogenous melatonin and circadian synchronization on tumor progression in melanoma-bearing C57BL6 mice. J. Pineal Res. 44:307-315, 2008.
140. Paim SL, Pires ML, Bittencourt LR, Silva RS, Santos RF, Esteves AM, Barreto AT, Tufik S, de Mello MT. Sleep complaints and polysomnographic findings: a study of nuclear power plant shift workers. Chronobiol. Int. 25:321-331, 2008.
141. Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH, Morton AJ: Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. J. Neurosci. 27:7869-7878, 2007.
142. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB: Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109:307-320, 2002.
143. Pedrazzoli M, Louzada FM, Pereira DS, Benedito-Silva AA, Lopez AR, Martynhak BJ, Korczak AL, Koike Bdel V, Barbosa AA, D'Almeida V, Tufik S: Clock polymorphisms and circadian rhythms phenotypes in a sample of the Brazilian population. Chronobiol. Int. 24:1-8, 2007.
144. Pereira DS, Tufik S, Louzada FM, Benedito-Silva AA, Lopez AR, Lemos NA, Korczak AL, D'Almeida V, Pedrazzoli M: Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? Sleep 28:29-32, 2005.
145. Perreau-Lenz S, Spanagel R: The effects of drugs of abuse on clock genes. Drug News Perspect. 21:211-217, 2008.
146. Pilorz V, Steinlechner S: Low reproductive success in Per1 and Per2 mutant mouse females due to accelerated ageing? Reproduction 135:559-568, 2008.
147. Portela LF, Rotenberg L, Waissmann W: Self-reported health and sleep complaints among nursing personnel working under 12 h night and day shifts. Chronobiol. Int. 21:859-870, 2004.
148. Preitner N, Daminola FL, Lopez-Molina L, Zakany J, Duboule D, Albrecht U, Schibler U: The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110:251-260, 2002.
149. Qu Y, Mao M, Li X, Liu Y, Ding J, Jiang Z, Wan C, Zhang L, Wang Z, Mu D: Telomerase reconstitution contributes to resetting of circadian rhythm in fibroblasts. Mol. Cell Biochem. 313:11-18, 2008.
150. Rafnsson V, Tulinius H, Jónasson JG, Hrafnkelsson J: Risk of breast cancer in female flight attendants: a population-based study (Iceland). Cancer Causes Control. 12:95-101, 2001.
151. Ralph MR, Foster RG, Davis FC, Menaker M: Transplanted suprachiasmatic nucleus determines circadian period. Science 247:975-978, 1990.
152. Ramakrishnan SN, Lau P, Burke LJ, Muscat GE: Rev-erbβ regulates the expression of genes involved in lipid absorption in skeletal muscle cells: evidence for cross-talk between orphan nuclear receptors and myokines. J. Biol. Chem. 280:8651-8659, 2005.
153. Reick M, Garcia JA, Dudley C, McKnight SL: NPAS2: an analog of clock operative in the mammalian forebrain. Science 293:506-509, 2001.
154. Reiter RJ, Tan DX, Korkmaz A, Erren TC, Piekarski C, Tamura H, Manchester LC: Light at night, chronodisruption, melatonin suppression, and cancer risk: a review. Crit. Rev. Oncog. 13:303-328, 2007.
155. Reppert SM, Weaver DR: Coordination of circadian timing in mammals. Nature 418:935-941, 2002.
156. Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack LM, English J, Leger D, Smits MG, Williams A, Skene DJ, Von Schantz M: The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects. J. Sleep Res. 11:305-312, 2002.
157. Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA: BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2:e377, 2004.
158. Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, Mcnamara P, Naik KA, FitzGerald GA, Kay SA, Hogenesch JB: A functional genomics strategy reveals Rorα as a component of the mammalian circadian clock. Neuron 43:527-537, 2004.
159. Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, Welsh DK, Kay SA, Ueda HR, Hogenesch JB: Feedback repression is required for mammalian circadian clock function. Nat. Genet. 38:312-319, 2006.
160. Schibler U, Ripperger J, Brown SA: Peripheral circadian oscillators in mammals: time and food. J. Biol. Rhythms 18:250-260, 2003.
161. Schwartz JR, Roth T: Shift work sleep disorder: burden of illness and approaches to management. Drugs 66:2357-2370, 2006.
162. Sephton SE, Sapolsky RM, Kraemer HC, Spiegel D: Diurnal cortisol rhythm as a predictor of breast cancer survival. J. Natl. Cancer Inst. 92:994-1000, 2000.
163. Shea SA, Hilton MF, Muller JE: Day/night pattern of myocardial infarction and sudden cardiac death. Interacting roles of the endogenous circadian system and behavioral triggers. In White WB (ed): Clinical Hypertension and Vascular Disease: Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, 2nd edn. Humana Press Inc, Totowa, 2007, pp. 253-291.
164. Shimba S, Ishii N, Ohta Y, Ohno T, Watabe Y, Hayashi M, Wada T, Aoyagi
165. Shirai H, Oishi K, Ishida N: Bidirectional CLOCK/BMAL1-dependent circadian gene regulation by retinoic acid in vitro. Biochem. Biophys. Res. Commun. 351:387-391, 2006.
166. Shirai H, Oishi K, Kudo T, Shibata S, Ishida N: PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders. Biochem. Biophys. Res. Commun. 357:679-682, 2007.
167. Siegel D, Black DM, Seeley DG, Hulley SB: Circadian variation in ventricular arrhythmias in hypertensive men. Am. J. Cardiol. 69:344-347, 1992.
168. Silver R, Schwartz WJ: The suprachiasmatic nucleus is a functionally heterogeneous timekeeping organ. Methods Enzymol. 393:451-465, 2005.
169. Sitzmann BD, Lemos DR, Ottinger MA, Urbanski HF: Effects of age on clock gene expression in the rhesus macaque pituitary gland. Neurobiol. Aging, 2008 [in press].
170. Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM: PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc. Natl. Acad. Sci. U.SA. 104:5223-5228, 2007.
171. Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, Weitz CJ: Extensive and divergent circadian gene expression in liver and heart. Nature 417:78-83, 2002.
172. Stratmann M, Schibler U: Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J. Biol. Rhythms 21:494-506, 2006.
173. Su TC, Lin LY, Baker D, Schnall PL, Chen MF, Hwang WC, Chen CF, Wang JD: Elevated blood pressure, decreased heart rate variability and incomplete blood pressure recovery after a 12-hour night shift work. J. Occup. Health 50:380-386, 2008.
174. Sudo N, Ohtsuka R: Fatigue complaints among female shift workers in a computer factory of Japan. J. Hum. Ergol. (Tokyo) 31:41-51, 2002.
175. Sun A, Unutmaz D, Zou Y, Sunshine MJ, Pierani A, Brenner-Morton S, Mebius RE, Littman DR: Requirement for RORγ in thymocyte survival and lymphoid organ development. Science 288: 2369-2373, 2000.
176. Sun Y, Yang Z, Niu Z, Peng J, Li Q, Xiong W, Langnas AN, Ma MY, Zhao Y: MOP3, a component of the molecular clock, regulates the development of B cells. Immunology 119:451-460, 2006.
177. Suzuki T, Sato F, Kondo J, Liu Y, Kusumi T, Fujimoto K, Kato Y, Sato T, Kijima H: Period is involved in the proliferation of human pancreatic MIA-PaCa2 cancer cells by TNF-α. Biomed. Res. 29:99-103, 2008.
178. Takano A, Uchiyama M, Kajimura N, Mishima K, Inoue Y, Kamei Y, Kitajima T, Shibui K, Katoh M, Watanabe T, Hashimotodani Y, Nakajima T, Ozeki Y, Hori T, Yamada N, Toyoshima R, Ozaki N, Okawa M, Nagai K, Takahashi K, Isojima Y, Yamauchi T, Ebisawa T: A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders. Neuropsychopharmacology 29:1901-1909, 2004.
179. Terazono H, Hamdan A, Matsunaga N, Hayasaka N, Kaji H, Egawa T, Makino K, Shigeyoshi Y, Koyanagi S, Ohdo S: Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: a possible mechanism of chemotherapy-induced circadian rhythm disturbances. Biochem. Pharmacol. 75:1616-1622, 2008.
180. Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM Ptáček LJ, Fu YH: An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291:1040-1043, 2001.
181. Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J: Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308:1043-1045, 2005.
182. Turek FW: From circadian rhythms to clock genes in depression. Int. Clin. Psychopharmacol. 22:S1-S8, 2007.
183. Ueda HR, Hayashi S, Chen W, Sano M, Machida M, Shigeyoshi Y, Iino M, Hashimoto S: System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat. Genet. 37:167-192, 2005.
184. Uz T, Ahmed R, Akhisaroglu M, Kurtuncu M, Imbesi M, Dirim Arslan A, Manev H: Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Neuroscience 134:1309-1316, 2005.
185. Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, Kramer A: Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev. 20:2660-2672, 2006.
186. Viola AU, Archer SN, James LM, Groeger JA, Lo JC, Skene DJ, von Schantz M, Dijk DJ: PER3 polymorphism predicts sleep structure and waking performance. Curr. Biol. 17:613-618, 2007.
187. Viola AU, James LM, Archer SN, Dijk DJ: PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase. Am. J. Physiol. Heart Circ. Physiol. 295:H2156-H2163, 2008.
188. Virkkunen H, Härmä M, Kauppinen T, Tenkanen L: Shift work, occupational noise and physical workload with ensuing development of blood pressure and their joint effect on the risk of coronary heart disease. Scand. J. Work Environ. Health 33:425-434, 2007.
189. Viswambharan H, Carvas JM, Antic V, Marecic A, Jud C, Zaugg CE, Ming XF, Montani JP, Albrecht U, Yang Z: Mutation of the circadian clock gene Per2 alters vascular endothelial function. Circulation 115:2188-2195, 2007.
190. Viswanathan AN, Hankinson SE, Schernhammer ES: Night shift work and the risk of endometrial cancer. Cancer Res. 67:10618-10622, 2007.
191. Wang J, Yin L, Lazar MA: The orphan nuclear receptor Rev-erbα regulates circadian expression of plasminogen activator inhibitor type 1. J. Biol. Chem. 281:33842-33848, 2006.
192. Wang N, Yang G, Jia Z, Zhang H, Aoyagi T, Soodvilai S, Symons JD, Schnermann JB, Gonzalez FJ, Litwin SE, Yang T: Vascular PPARγ controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab. 8:482-491, 2008.
193. Welsh DK, Yoo SH, Liu AC, Takahashi JS, Kay SA: Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr. Biol. 14:2289-2295, 2004.
194. Wisor JP, O'Hara BF, Terao A, Selby CP, Kilduff TS, Sancar A, Edgar DM, Franken P: A role for cryptochromes in sleep regulation. BMC Neurosci. 3:20, 2002.
195. Wisor JP, Pasumarthi RK, Gerashchenko D, Thompson CL, Pathak S, Sancar A, Franken P, Lein ES, Kilduff TS: Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains. J. Neurosci. 28:7193-7201, 2008.
196. Wood PA, Du-Quiton J, You S, Hrushesky WJ: Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index. Mol. Cancer Ther. 5:2023-2033, 2006.
197. Woon PY, Kaisaki PJ, Bragança J, Bihoreau MT, Levy JC, Farrall M, Gauguier D: Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc. Natl. Acad. Sci. U.S.A. 104:14412-14417, 2007.
198. Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptáček LJ, Fu YH: Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome. Nature 434:640-644, 2005.
199. Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptáček LJ: Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128:59-70, 2007.
200. Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, Ueda M, Block GD, Sakaki Y, Menaker M, Tei H: Resetting central and peripheral circadian oscillators in transgenic rats. Science 288:682-685, 2000.
201. Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD: Effects of aging on central and peripheral mammalian clocks. Proc. Natl. Acad. Sci. U.S.A. 99:10801-10806, 2002.
202. Yang S, Van Dongen HP, Wang K, Berrettini W, Buán M: Assessment of circadian function in fibroblasts of patients with bipolar disorder. Mol. Psychiatry 14:143-155, 2009.
203. Yang WS, Stockwell BR: Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 9:R92, 2008.
204. Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM: Nuclear receptor expression links the circadian clock to metabolism. Cell 126:801-810, 2006.
205. Yang X, Wood PA, Oh EY, Du-Quiton J, Ansell CM, Hrushesky WJ: Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm. Breast Cancer Res. Treat. 2008 [in press].
206. Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ, Menaker M, Takahashi JS: PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc. Natl. Acad. Sci. U.S.A. 101:5339-5346, 2004.
207. You S, Wood PA, Xiong Y, Kobayashi M, Du-Quiton J, Hrushesky WJ: Daily coordination of cancer growth and circadian clock gene expression. Breast Cancer Res. Treat. 91:47-60, 2005.
208. Young MR, Matthews JP, Kanabrocki EL, Sothern RB, Roitman-Johnson B, Scheving LE: Circadian rhythmometry of serum interleukin-2, interleukin-10, tumor necrosis factor-α, and granulocyte-macrophage colony-stimulating factor in men. Chronobiol. Int. 12:19-27, 1995.
209. Young ME, Bray MS: Potential role for peripheral circadian clock dyssynchrony in the pathogenesis of cardiovascular dysfunction. Sleep Med. 8:656-667, 2007.
210. Zhu Y, Brown HN, Zhang Y, Stevens RG, Zheng T: Period3 structural variation: a circadian biomarker associated with breast cancer in young women. Cancer Epidemiol. Biomarkers Prev. 14:268-270, 2005.