High genetic diversity and poor in vitro response to antifungals of clinical strains of Fusarium oxysporum

Journal of Antimicrobial Chemotherapy

Volumn 63, Issue 6, 2009, Pages 1152-1155

  Azor, Mónica ^a   Cano, Josep ^a   Gené, Josepa ^a   Guarro, Josep ^a,b  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b FACULTAT DE MEDICINA I CIÈNCIES DE LA SALUT   (Spain)

Author keywords

Antifungal susceptibility; Elongation factor 1 gene; Fusarium; Molecular identification

Indexed keywords

ALBACONAZOLE; AMPHOTERICIN B; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; KETOCONAZOLE; MICAFUNGIN; POSACONAZOLE; RAVUCONAZOLE; TERBINAFINE; VORICONAZOLE;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BROTH DILUTION; CONTROLLED STUDY; FUNGAL MORPHOLOGY; FUNGAL STRAIN; FUNGUS ISOLATION; FUSARIUM OXYSPORUM; GENE IDENTIFICATION; GENETIC VARIABILITY; GENOME ANALYSIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; SEQUENCE ANALYSIS;

ANTIFUNGAL AGENTS; CLUSTER ANALYSIS; FUNGAL PROTEINS; FUSARIUM; GENETIC VARIATION; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MYCOSES; PEPTIDE ELONGATION FACTOR 1; PHYLOGENY; SEQUENCE ANALYSIS, DNA;

EID: 65749089232     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp095     Document Type: Article

References (10)

1. Nelson PE, Dignani MC, Anaissie EJ. Taxonomy, biology, and clinical aspects of Fusarium species. Clin Microbiol Rev 1994; 7 479-504.
2. Azor M, Gené J, Cano J et al. Universal in vitro antifungal resistance of genetic clades of the Fusarium solani species complex. Antimicrob Agents Chemother 2007; 51: 1500-3.
3. Alastruey-Izquierdo A, Cuenca-Estrella M, Monzón A et al. Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods. J Antimicrob Chemother 2008; 61: 805-9.
4. Sabatelli F, Patel R, Mann PA et al. In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrob Agents Chemother 2006; 50: 2009-15.
5. O'Donnell K, Sutton DA, Rinaldi MG et al. Genetic diversity of human pathogenic members of the Fusarium oxysporum complex inferred from multilocus DNA sequence data and amplified fragment length polymorphism analyses: Evidence for the recent dispersion of a geographically widespread clonal lineage and nosocomial origin. J Clin Microbiol 2004; 42: 5109-20.
6. O'Donnell K. Molecular phylogeny of the Nectria haematococca-Fusarium solani species complex. Mycologia 2000; 92: 919-38.
7. Gilgado F, Cano J, Genée J et al. Molecular phylogeny of the Pseudallescheria boydii species complex: Proposal of two new species. J Clin Microbiol 2005; 43: 4930-42.
8. Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi - Second Edition: Approved Standard M38-A2. CLSI, Wayne, PA, USA, 2008.
9. Krcmery V Jr, Jesenska Z, Spanik S et al. Fungaemia due to Fusarium spp. in cancer patients. J Hosp Infect 1997; 36: 223-8.
10. Gorman SR, Magiorakos AP, Zimmerman SK et al. Fusarium oxysporum pneumonia in an immunocompetent host. South Med J 2006; 99: 613-6.