Effect of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on testosterone release from rat leydig cells

Phytotherapy Research

Volumn 23, Issue 5, 2009, Pages 687-695

  Hsia, Shih Min ^a,b   Tseng, Yi Wen ^b   Wang, Shyi Wu ^c   Kuo, Yueh Hsiung ^d   Huang, Din Wen ^b   Wang, Paulus S ^b,e,f   Chiang, Wenchang ^b  

^a CARDINAL TIEN COLLEGE OF HEALTHCARE AND MANAGEMENT   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

^f TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

Adlay hulls; Leydig cell; Testosterone

Indexed keywords

8 BROMO CYCLIC AMP; ANDROSTENEDIONE; CALCIMYCIN; CHORIONIC GONADOTROPIN; COIX LACHRYMA JOBI EXTRACT; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GONADORELIN; LUTEINIZING HORMONE; PLANT EXTRACT; PROGESTERONE; PROTEIN KINASE C; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COIX LACRYMA JOBI; CULTURE MEDIUM; DRUG EFFECT; ENZYME ACTIVITY; HORMONE RELEASE; IN VITRO STUDY; INCUBATION TIME; LEYDIG CELL; MALE; MEDICINAL PLANT; NONHUMAN; PLANT SEED; RAT; SIGNAL TRANSDUCTION; TESTOSTERONE RELEASE; TESTOSTERONE SYNTHESIS; ANIMAL; CELL CULTURE; CHEMISTRY; COIX; METABOLISM; SECRETION; SPRAGUE DAWLEY RAT;

COIX LACRYMA-JOBI; RATTUS;

ANIMALS; CELLS, CULTURED; COIX; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUGS, CHINESE HERBAL; GONADOTROPIN-RELEASING HORMONE; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; PITUITARY GLAND, ANTERIOR; PLANT EXTRACTS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 65649124104     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2706     Document Type: Article

References (29)

1. Bernier M, Clerget M, Berthelon MC, Saez JM. 1987. Stimulatory and inhibitory effects of protein kinase C activation and calcium ionophore on cultured pig Leydig cells. Eur J Biochem 163: 181-188.
2. Chang HC, Huang YC, Hung WC. 2003. Antiproliferative and chemopreventive effects of adlay seed on lung cancer in vitro and in vivo. J Agric Food Chem 51: 3656-3660.
3. Chang LL, Wun AW, Hung CT, Hsia SM, Chiang W, Wang PS. 2006. Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells. Naunyn Schmiedebergs Arch Pharmacol 374: 141-152.
4. Dirami G, Poulter LW, Cooke BA. 1991. Separation and characterization of Leydig cells and macrophages from rat testes. J Endocrinol 130: 357-365.
5. Hadley ME. 2000. Hormones and male reproduction physiology. In Endocrinology, 5th edn, Hadley ME (ed.). Prentice Hall: Englewood Cliffs, NJ, 422-444.
6. Hsia SM, Chiang W, Kuo YH, Wang PS. 2006. Downregulation of progesterone biosynthesis in rat granulosa cells by adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) bran extracts. Int J Impotence Res 18: 264-274.
7. Hsia SM, Yeh CL, Kuo YH, Wang PS, Chiang W. 2007. Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extract on the secretion of progesterone and estradiol in vivo and in vitro. Exp Biol Med 232: 1181-1194.
8. Hsu HY, Lin BF, Lin JY, Kuo CC, Chiang W. 2003. Suppression of allergic reactions by dehulled adlay in association with the balance of TH1/TH2 cell responses. J Agric Food Chem 51: 3763-3769.
9. Huang WJ, Yeh JY, Kan SF, Chang LS, Wang PS. 2001. Effects of hyperprolactinemia on testosterone production in rat Leydig cells. J Cell Biochem 80: 313-320.
10. Hung WC, Chang HC. 2003. Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription. J Agric Food Chem 51: 7333-7337.
11. Hwang C, Pu HF, Hwang CY et al. 1990. Age-related differences in the release of luteinizing hormone and gonadotropinreleasing hormone in ovariectomized rats. Neuroendocrinology 52: 127-132.
12. Krummen LA, Woodruff TK, Covello R, Taylor R, Working P, Mather JP. 1994. Localization of inhibin and activin binding sites in the testis during development by in situ ligand binding. Biol Reprod 50: 734-744.
13. Kuo CC, Chiang W, Liu GP et al. 2002. 2,2′-Diphenyl-1- picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls. J Agric Food Chem 50: 5850-5855.
14. Kuo CC, Shih MC, Kuo YH, Chiang W. 2001. Antagonism of free-radical-induced damage of adlay seed and its antiproliferative effect in human histolytic lymphoma U937 monocytic cells. J Agric Food Chem 49: 1564-1570.
15. Kurosumi M, Ishimura K, Yoshinaga T, Fujita H, Tamaoki B. 1986. Immunocytochemical localization of 17 beta-hydroxysteroid dehydrogenase in porcine testis. Histochemistry 85: 287-289.
16. Li SC Pen-t's sao kang mu (Systematic Pharmacopoeia). In China: 1596.
17. Ohno S, Shinoda S, Toyoshima S, Nakazawa H, Makino T, Nakajin S. 2002. Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. J Steroid Biochem Mol Biol 80: 355-363.
18. Pakrashi A, Kabir SN, Ray H. 1981. 3-(4-Hydroxy phenyl)-2- propenoic acid - a reproductive inhibitor in male rat. Contraception 23: 677-686.
19. Pakrashi A, Pakrasi P. 1979. Antifertility effects of the plant Aristolochia indica Linn on mouse. Contraception 20: 49-54.
20. Papiez MA. 2004. Influence of naringenin on the activity of enzymes participating in steroidogenesis in male rats. Roczniki Akademii Medycznej Bialymstoku 49(Suppl 1): 120-122.
21. Payne AH, O'Shaughnessy PJ. 1996. Structure, function and regulation of steroidogenic enzymes in the Leydig cell. In The Leydig Cell, Payne AH, Hardy MR Russell LD (eds). Cache River Press: Vienna, 259-286.
22. Payne AH, Sha LL. 1991. Multiple mechanisms for regulation of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4- isomerase, 17 alpha-hydroxylase/C17-20 lyase cytochrome P450, and cholesterol side-chain cleavage cytochrome P450 messenger ribonucleic acid levels in primary cultures of mouse Leydig cells. Endocrinology 129: 1429-1435.
23. Takahashi M, Konno C, Hikino H. 1986. Isolation and hypoglycemic activity of coixans A, B and C, glycans of Coix lachryma-jobi var. ma-yuen seeds. Planta Med 56: 64-65.
24. Tsai SC, Chiao YC, Lu CC et al. 1996. Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes. Br J Pharmacol 118: 984-988.
25. Tsai SC, Chiao YC, Lu CC, Wang PS. 2003. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol 46: 1-7.
26. Tzeng HP, Chiang W, Ueng TH, Liu SH. 2005. The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. J Toxicol Environ Health A 68: 1557-1565.
27. Wang SC. 2002. Quantification and Comparison of Physiological Components in Adlay Seeds. M.S. Thesis. Graduate Institute of Food Science and Technology National Taiwan University: Taipei, Taiwan, ROC.
28. Wang SW, Chiao YC, Tsai SC et al. 1997. Inhibition of bufalin on pituitary and testicular function in rats. J Pharmacol Exp Ther 283: 528-532.
29. Wang SW, Lin H, Tsai SC et al. 1998. Effects of methanol extract of Chansu on hypothalamic-pituitary-testis function in rats. Metabolism 47: 1211-1216.