A mathematical model of aging-related and cortisol induced hippocampal dysfunction

BMC Neuroscience

Volumn 10, Issue , 2009, Pages

  McAuley, Mark T ^a   Kenny, Rose Anne ^b   Kirkwood, Thomas B L ^a   Wilkinson, Darren J ^c   Jones, Janette J L ^d   Miller, Veronica M ^e,f  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNILEVER RESEARCH   (United Kingdom)

^e NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^f WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE;

AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; HIPPOCAMPUS; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MARKUP LANGUAGE; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; ATROPHY; BIOLOGY; BLOOD; COMPUTER SIMULATION; DEGENERATIVE DISEASE; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; PATHOLOGY; PATHOPHYSIOLOGY; THEORETICAL MODEL;

AGING; ATROPHY; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HIPPOCAMPUS; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MODELS, THEORETICAL; NEURODEGENERATIVE DISEASES; PITUITARY-ADRENAL SYSTEM;

EID: 65649122684     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-10-26     Document Type: Article

References (33)

1. Scher AI Xu Y Korf ES White LR Scheltens P Toga AW Thompson PM Hartley SW Witter MP Valentino DJ Launer LJ Hippocampal shape analysis in Alzheimer's disease: A population-based study Neuroimage 2007, 36:8-18. 10.1016/j.neuroimage.2006.12.036 17434756
2. Giannakopoulos P von Gunten A Kovari E et al Stereological analysis of neuropil threads in the hippocampal formation: Relationships with Alzheimer's disease neuronal pathology and cognition Neuropathol Appl Neurobiol 2007, 33:334-343. 10.1111/j.1365-2990.2007.00827.x 17442063
3. Kril JJ Hodges J Halliday G Relationship between hippocampal volume and CA1 neuron loss in brains of humans with and without Alzheimer's disease Neurosci Lett 2004, 361(1-3):9-12. 10.1016/j.neulet.2004.02.001 15135880
4. Korf ES White LR Scheltens P Launer LJ Brain aging in very old men with type 2 diabetes: The Honolulu-Asia Aging Study Diabetes Care 2006, 29:2268-74. 10.2337/dc06-0243 17003305
5. Korf ES White LR Scheltens P Launer LJ Midlife blood pressure and the risk of hippocampal atrophy: The Honolulu Asia Aging Study Hypertension 2004, 44:29-34. 10.1161/01.HYP.0000132475.32317.bb 15159381
6. Lupien SJ Schwartz G Ng YK et al The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: Summary of findings J Psychiatry Neurosci 2005, 30:328-34. 1197277 16151537
7. Wright CE Kunz-Ebrecht SR Iliffe S Foese O Steptoe A Physiological correlates of cognitive functioning in an elderly population Psychoneuroendocrinology 2005, 30:826-38. 10.1016/j.psyneuen.2005.04.001 15975730
8. Wright RL Lightner EN Harman JS Meijer OC Conrad CD Attenuating corticosterone levels on the day of memory assessment prevents chronic stress-induced impairments in spatial memory Eur J Neurosci 2006, 24:595-605. 1550977 16903861 10.1111/j.1460-9568.2006.04948.x
9. De Kloet ER Oitzl MS Joels M et al Brain corticosteroid receptor balance in health and disease Endocrin Rev 1998, 19:269-301. 10.1210/er.19.3.269
10. Bennett MC Diamond DM Fleshner M Rose GM Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation Hippocampus 1992, 2:421-30. 10.1002/ hipo.450020409 1308198
11. Lupien SJ Ng YK Fiocco A Wan N Pruessner JC Meaney MJ Schwartz G Nair NP The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: Summary of findings J Psychiatry Neurosci 2005, 30:328-34. 1197277 16151537
12. de Leon M Lupien SJ de Santi S Convit A Tarshish C Nair NP Thakur M McEwen BS Hauger RL Meaney MJ Cortisol levels during human aging predict hippocampal atrophy and memory deficits Nature Neuroscience 1998, 1:69-73. 10.1038/271 10195112
13. Landfield PW Porter NM Stress hormones and brain aging; adding injury to insult Nature Neuroscience 1998, 1:3-4. 10.1038/196 10195096
14. Traustadottir T Bosch PR Matt KS The HPA axis response to stress in women: Effects of aging and fitness Psychoneuroendocrinology 2005, 30:392-402. 10.1016/j.psyneuen.2004.11.002 15694119
15. Wilkinson CW Peskind ER Raskind MA Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging Neuroendocrinology 1997, 65:79-90. 10.1159/ 000127167 9032777
16. Wilkinson CW Petrie EC Murray SR Colasurdo EA Raskind MA Peskind ER Human glucocorticoid feedback inhibition is reduced in older individuals: Evening study J Clin Endocrinol Metab 2001, 86:545-50. 10.1210/jc.86.2.545 11158007
17. Hertoghe T "The multiple hormone deficiency" theory of aging: is human senescence caused mainly by multiple hormone deficiencies? Ann N Y Acad Sci 2005, 1057:448-65. 10.1196/annals.1322.035 16399912
18. Buss C Wolf OT Witt J Hellhammer DH Autobiographic memory impairment following acute cortisol administration Psychoneuroendocrinology 2004, 29:1093-6. 10.1016/j.psyneuen.2003.09.006 15219661
19. Caballol N Marti MJ Tolosa E "Cognitive dysfunction and dementia in Parkinson disease." Mov Disord 2007, 22:S358-S366. 10.1002/mds.21677
20. Moorhouse P Rockwood K "Vascular cognitive impairment: Current concepts and clinical developments." Lancet Neurol 2008, 7.3:246-55. 10.1016/S1474-4422(08)70040-1
21. Cook SC Wellman CL "Chronic stress alters dendritic morphology in rat medial prefrontal cortex." J Neurobiol 2004, 60.2:236-48. 10.1002/neu.20025
22. Luine VN Beck KD Bowman RE Frankfurt M Maclusky NJ Chronic stress and neural function: Accounting for sex and age J Neuroendocrinol 2007, 19:743-51. 10.1111/j.1365-2826.2007.01594.x 17850456
23. Hucka M Finney A Sauro HM Bolouri H Doyle JC Kitano H Arkin AP Bornstein BJ Bray D Cornish-Bowden A Cuellar AA Dronov S Gilles ED Ginkel M Gor V Goryanin II Hedley WJ Hodgman TC Hofmeyr JH Hunter PJ Juty NS Kasberger JL Kremling A Kummer U Le Novère N Loew LM Lucio D Mendes P Minch E Mjolsness ED Nakayama Y Nelson MR Nielsen PF Sakurada T Schaff JC Shapiro BE Shimizu TS Spence HD Stelling J Takahashi K Tomita M Wagner J Wang J SBML Forum The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models Bioinformatics 2003, 19:524-31. 10.1093/bioinformatics/btg015 12611808
24. Regestein QR Jackson WJ Peterson HF Effects of various hippocampal lesions on monkey plasma cortisol levels in two experimental conditions Behav Neural Biol 1986, 45:329-41. 10.1016/S0163-1047(86)80021-8 3718397
25. Jelic S Cupic Z Kolar-Anic L Mathematical modeling of the hypothalamic-pituitary-adrenal system activity Math Biosci 2005, 197:173-87. 10.1016/j.mbs.2005.06.006 16112688
26. Lenbury Y Pornsawad P A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans Math Med Biol 2005, 22:15-33. 10.1093/imammb/dqh020 15716298
27. Brown EN Meehan PM Dempster AP A stochastic differential equation model of diurnal cortisol patterns Am J Physiol Endocrinol Metab 2001, 280:E450-61. 11171600
28. Gonzalez-Heydrich J Steingard RJ Putnam F Beardslee W Kohane IS Using 'off the shelf', computer programs to mine additional insights from published data: Diurnal variation in potency of ACTH stimulation of cortisol secretion revealed Comput Methods Programs Biomed 1999, 58:227-38. 10.1016/S0169-2607(98)00086-8 10094227
29. Li G Liu B Liu Y A dynamical model of the pulsatile secretion of the hypothalamo-pituitary-thyroid axis Biosystems 1995, 35:83-92. 10.1016/ 0303-2647(94)01484-O 7772725
30. Deuschle M Gotthardt U Schweiger U et al With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens Life Sci 1997, 61:2239-46. 10.1016/ S0024-3205(97)00926-0 9393943
31. Van Cauter E Leproult R Kupfer DJ Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol J Clin Endocrinol Metab 1996, 81:2468-2473. 10.1210/jc.81.7.2468 8675562
32. Wolf OT et al "Subjective memory complaints in aging are associated with elevated cortisol levels." Neurobiol Aging 2005, 26:1357-63. 10.1016/j.neurobiolaging.2004.11.003 16243606
33. Dayan Peter Abbott LF Theoretical Neuroscience Computational and Mathematical Modeling of Neural Systems Cambridge, Mass: MIT Press 2001, xv:460.