Relationship between FDG uptake and expressions of glucose transporter type 1, type 3, and hexokinase-II in Reed-Sternberg cells of Hodgkin lymphoma

Oncology Research

Volumn 17, Issue 7, 2009, Pages 331-337

  Shim, Hye Kyung ^a   Lee, Won Woo ^a,b   Park, So Yeon ^a   Kim, Haeryoung ^a   Kim, Sang Eun ^a,b  

^a Seoul National University Bundang Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

FDG PET; Glucose transporter; Hexokinase; Hodgkin lymphoma

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 3; HEXOKINASE; RADIOPHARMACEUTICAL AGENT; SLC2A2 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; ENZYME IMMUNOASSAY; FEMALE; HODGKIN DISEASE; HUMAN; MALE; METABOLISM; MIDDLE AGED; POSITRON EMISSION TOMOGRAPHY; REED STERNBERG CELL; SCINTISCANNING;

ADULT; AGED; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 2; GLUCOSE TRANSPORTER TYPE 3; HEXOKINASE; HODGKIN DISEASE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REED-STERNBERG CELLS; YOUNG ADULT;

EID: 65649121988     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504009787721177     Document Type: Article

References (22)

1. Yung, L.; Linch, D. Hodgkin's lymphoma. Lancet 361:943-951; 2003.
2. Thomas, R. K.; Re, D.; Wolf, J.; Diehl, V. Part I: Hodgkin's lymphoma-molecular biology of Hodgkin and Reed-Sternberg cells. Lancet Oncol. 5:11-18; 2004.
3. Portlock, C. S.; Yahaom, J. Hodgkin's disease. In: Gill, G. N.; Kokko, J. P.; Mandell, G. L.; Ockner, R. K.; Smith, T. W., eds. Cecil textbook of medicine. Philadelphia: W. B. Saunders Co.; 1996:947-955.
4. Newman, J. S.; Francis, I. R.; Kaminski, M. S.; Wahl, R. L. Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose: correlation with CT. Radiology 190:111-116; 1994.
5. de Wit, M.; Bohuslavizki, K. H.; Buchert, R.; Bumann, D.; Clausen, M.; Hossfeld, D. K. 18FDG-PET following treatment as valid predictor for disease-free survival in Hodgkin's lymphoma. Ann. Oncol. 12:29-37; 2001.
6. Hueltenschmidt, B.; Sautter-Bihl, M. L.; Lang, O.; Maul, F. D.; Fischer, J.; Mergenthaler, H. G.; Bihl, H. Whole body positron emission tomography in the treatment of Hodgkin disease. Cancer 91:302-310; 2001. (Pubitemid 32099230)
7. Jerusalem, G.; Beguin, Y.; Fassotte, M. F.; Najjar, F.; Paulus, P.; Rigo, P.; Fillet, G. Whole-body positron emission tomography using 18F-fluorodeoxyglucose compared to standard procedures for staging patients with Hodgkin's disease. Haematologica 86:266-273; 2001. (Pubitemid 32291064)
8. Seam, P.; Juweid, M. E.; Cheson, B. D. The role of FDG-PET scans in patients with lymphoma. Blood 110:3507-3516; 2007.
9. Macheda, M. L.; Rogers, S.; Best, J. D. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J. Cell. Physiol. 202:654-662; 2005.
10. Pedersen, P. L. Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect," i.e., elevated glycolysis in the presence of oxygen. J. Bioenerg. Biomembr. 39:211-222; 2007.
11. Wahl, R. L. Principles and practice of positron emission tomography. Philadelphia: Lippincott Williams and Wilkins; 2002.
12. Reske, S. N.; Grillenberger, K. G.; Glatting, G.; Port, M.; Hildebrandt, M.; Gansauge, F.; Beger, H. G. Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma. J. Nucl. Med. 38:1344-1348; 1997.
13. Brown, R. S.; Goodman, T. M.; Zasadny, K. R.; Green son, J. K.; Wahl, R. L. Expression of hexokinase II and Glut-1 in untreated human breast cancer. Nucl. Med. Biol. 29:443-453; 2002.
14. Chung, J. H.; Lee, W. W.; Park, S. Y.; Choe, G.; Sung, S. W.; Chung, J. K.; Lee, M. C.; Kim, S. E. FDG uptake and glucose transporter type 1 expression in lymph nodes of non-small cell lung cancer. Eur. J. Surg. Oncol. 32: 989-995; 2006.
15. Nguyen, X. C.; Lee, W. W.; Chung, J. H.; Park, S. Y.; Sung, S. W.; Kim, Y. K.; So, Y.; Lee, D. S.; Chung, J. K.; Lee, M. C.; Kim, S. E. FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: Correlations and prognostic values. Eur. J. Radiol. 62:214-219; 2007.
16. Nguyen, X. C.; So, Y.; Chung, J. H.; Lee, W. W.; Park, S. Y.; Kim, S. E. High correlations between primary tumours and loco-regional metastatic lymph nodes in non-small-cell lung cancer with respect to glucose transporter type 1-mediated 2-deoxy-2-F18-fluoro-d-glucose uptake. Eur. J. Cancer 44:692-698; 2008.
17. Song, Y. S.; Lee, W. W.; Chung, J. H.; Park, S. Y.; Kim, Y. K.; Kim, S. E. Correlation between FDG uptake and glucose transporter type 1 expression in neuroendocrine tumors of the lung. Lung Cancer 61:54-60; 2008.
18. Tian, M.; Zhang, H.; Nakasone, Y.; Mogi, K.; Endo, K. Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study. Eur. J. Nucl. Med. Mol. Imaging 31:5-12; 2004.
19. Aloj, L.; Caraco, C.; Jagoda, E.; Eckelman, W. C.; Neumann, R. D. Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture. Cancer Res. 59:4709-4714; 1999.
20. Mathupala, S. P.; Rempel, A.; Pedersen, P. L. Aberrant glycolytic metabolism of cancer cells: A remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase. J. Bioenerg. Biomembr. 29:339-343; 1997.
21. Higgins, R. A.; Blankenship, J. E.; Kinney, M. C. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch. Pathol. Lab. Med. 132:441-461; 2008.
22. Brauninger, A.; Schmitz, R.; Bechtel, D.; Renne, C.; Hansmann, M. L.; Kuppers, R. Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma. Int. J. Cancer 118:1853-1861; 2006.