The RB/E2F pathway and regulation of RNA processing

Biochemical and Biophysical Research Communications

Volumn 384, Issue 3, 2009, Pages 280-283

  Ahlander, Joseph ^a   Bosco, Giovanni ^a  

^a University of Arizona   (United States)

Author keywords

E2F; Pre mRNA splicing; RB; Retinoblastoma tumor suppressor; RNA processing

Indexed keywords

RETINOBLASTOMA PROTEIN; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR E2F;

ALTERNATIVE RNA SPLICING; CONCEPTUAL FRAMEWORK; CYTOLOGY; DEVELOPMENTAL BIOLOGY; GENE EXPRESSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RNA BINDING; RNA PROCESSING; RNA TRANSCRIPTION; RNA TRANSPORT; SHORT SURVEY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANIMALS; E2F TRANSCRIPTION FACTORS; HUMANS; RETINOBLASTOMA PROTEIN; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC;

EID: 65649119389     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.04.107     Document Type: Short Survey

References (49)

1. van den Heuvel S., and Dyson N.J. Conserved functions of the pRB and E2F families. Nat. Rev. Mol. Cell Biol. 9 (2008) 713-724
2. Morris E.J., and Dyson N.J. Retinoblastoma protein partners. Adv. Cancer Res. 82 (2001) 1-54
3. Prathapam T., Kuhne C., and Banks L. Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. Nucleic Acids Res. 30 (2002) 5261-5268
4. Figueroa J.D., and Hayman M.J. The human ski-interacting protein functionally substitutes for the yeast PRP45 gene. Biochem. Biophys. Res. Commun. 319 (2004) 1105-1109
5. Johnson E.M., Chen P.L., Krachmarov C.P., Barr S.M., Kanovsky M., Ma Z.W., and Lee W.H. Association of human pur alpha with the retinoblastoma protein, rb, regulates binding to the single-stranded DNA pur alpha recognition element. J. Biol. Chem. 270 (1995) 24352-24360
6. Darbinian N., Gallia G.L., Kundu M., Shcherbik N., Tretiakova A., Giordano A., and Khalili K. Association of pur alpha and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene 18 (1999) 6398-6402
7. White M.K., Johnson E.M., and Khalili K. Multiple roles for puralpha in cellular and viral regulation. Cell. Cycle 8 (2009) 1-7
8. Hagemeier C., Bannister A.J., Cook A., and Kouzarides T. The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc. Natl. Acad. Sci. USA 90 (1993) 1580-1584
9. Kastner P., and Chan S. PU.1: a crucial and versatile player in hematopoiesis and leukemia. Int. J. Biochem. Cell Biol. 40 (2008) 22-27
10. Rekhtman N., Choe K.S., Matushansky I., Murray S., Stopka T., and Skoultchi A.I. PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation. Mol. Cell Biol. 23 (2003) 7460-7474
11. Hallier M., Tavitian A., and Moreau-Gachelin F. The transcription factor spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. J. Biol. Chem. 271 (1996) 11177-11181
12. Hallier M., Lerga A., Barnache S., Tavitian A., and Moreau-Gachelin F. The transcription factor spi-1/PU.1 interacts with the potential splicing factor TLS. J. Biol. Chem. 273 (1998) 4838-4842
13. Guillouf C., Gallais I., and Moreau-Gachelin F. Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner. J. Biol. Chem. 281 (2006) 19145-19155
14. Darville M.I., and Rousseau G.G. E2F-dependent mitogenic stimulation of the splicing of transcripts from an S phase-regulated gene. Nucleic Acids Res. 25 (1997) 2759-2765
15. Kornblihtt A.R. Promoter usage and alternative splicing. Curr. Opin. Cell Biol. 17 (2005) 262-268
16. Adegbola O., and Pasternack G.R. Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis. J. Biol. Chem. 280 (2005) 15497-15502
17. Adegbola O., and Pasternack G.R. A pp32-retinoblastoma protein complex modulates androgen receptor-mediated transcription and associates with components of the splicing machinery. Biochem. Biophys. Res. Commun. 334 (2005) 702-708
18. Rehwinkel J., Herold A., Gari K., Kocher T., Rode M., Ciccarelli F.L., Wilm M., and Izaurralde E. Genome-wide analysis of mRNAs regulated by the THO complex in drosophila melanogaster. Nat. Struct. Mol. Biol. 11 (2004) 558-566
19. Li Y., Lin A.W., Zhang X., Wang Y., Wang X., and Goodrich D.W. Cancer cells and normal cells differ in their requirements for Thoc1. Cancer Res. 67 (2007) 6657-6664
20. Doostzadeh-Cizeron J., Evans R., Yin S., and Goodrich D.W. Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with rb protein. Mol. Biol. Cell 10 (1999) 3251-3261
21. Dimova D.K., Stevaux O., Frolov M.V., and Dyson N.J. Cell cycle-dependent and cell cycle-independent control of transcription by the drosophila E2F/RB pathway. Genes Dev. 17 (2003) 2308-2320
22. Durfee T., Mancini M.A., Jones D., Elledge S.J., and Lee W.H. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J. Cell Biol. 127 (1994) 609-622
23. Mancini M.A., Shan B., Nickerson J.A., Penman S., and Lee W.H. The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. Proc. Natl. Acad. Sci. USA 91 (1994) 418-422
24. Ahlander J., Chen X.B., and Bosco G. The N-terminal domain of the drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent manner. PLoS One 3 (2008) e2831
25. Quinones-Coello A.T., Petrella L.N., Ayers K., Melillo A., Mazzalupo S., Hudson A.M., Wang S., Castiblanco C., Buszczak M., Hoskins R.A., and Cooley L. Exploring strategies for protein trapping in drosophila. Genetics 175 (2007) 1089-1104
26. Nilson L.A., and Schupbach T. EGF receptor signaling in drosophila oogenesis. Curr. Top. Dev. Biol. 44 (1999) 203-243
27. Park J.W., Parisky K., Celotto A.M., Reenan R.A., and Graveley B.R. Identification of alternative splicing regulators by RNA interference in drosophila. Proc. Natl. Acad. Sci. USA 101 (2004) 15974-15979
28. Young A.P., Nagarajan R., and Longmore G.D. Mechanisms of transcriptional regulation by rb-E2F segregate by biological pathway. Oncogene 22 (2003) 7209-7217
29. Li Z., Kreutzer M., Mikkat S., Mise N., Glocker M.O., and Putzer B.M. Proteomic analysis of the E2F1 response in p53-negative cancer cells: new aspects in the regulation of cell survival and death. Proteomics 6 (2006) 5735-5745
30. G. Merdzhanova, V. Edmond, S. De Seranno, A. Van den Broeck, L. Corcos, C. Brambilla, E. Brambilla, S. Gazzeri, B. Eymin, E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35, Cell Death Differ., 2008.
31. Morris E.J., Michaud W.A., Ji J.Y., Moon N.S., Rocco J.W., and Dyson N.J. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet. 2 (2006) e196
32. Ceron J., Rual J.F., Chandra A., Dupuy D., Vidal M., and van den Heuvel S. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. BMC Dev. Biol. 7 (2007) 30
33. Ma Y., Croxton R., Moorer Jr. R.L., and Cress W.D. Identification of novel E2F1-regulated genes by microarray. Arch. Biochem. Biophys. 399 (2002) 212-224
34. Hughes T.A., and Brady H.J. E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem. Biophys. Res. Commun. 329 (2005) 1267-1274
35. Woods K., Thomson J.M., and Hammond S.M. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J. Biol. Chem. 282 (2007) 2130-2134
36. Petrocca F., Visone R., Onelli M.R., Shah M.H., Nicoloso M.S., de Martino I., Iliopoulos D., Pilozzi E., Liu C.G., Negrini M., Cavazzini L., Volinia S., Alder H., Ruco L.P., Baldassarre G., Croce C.M., and Vecchione A. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13 (2008) 272-286
37. Wang D., Kennedy S., Conte Jr. D., Kim J.K., Gabel H.W., Kamath R.S., Mello C.C., and Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 436 (2005) 593-597
38. Lehner B., Calixto A., Crombie C., Tischler J., Fortunato A., Chalfie M., and Fraser A.G. Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Genome Biol. 7 (2006) R4
39. Ouellet J., and Roy R. The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans. BMC Dev. Biol. 7 (2007) 38
40. Grishok A., Hoersch S., and Sharp P.A. RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 105 (2008) 20386-20391
41. Cramer P., Pesce C.G., Baralle F.E., and Kornblihtt A.R. Functional association between promoter structure and transcript alternative splicing. Proc. Natl. Acad. Sci. USA 94 (1997) 11456-11460
42. Monsalve M., Wu Z., Adelmant G., Puigserver P., Fan M., and Spiegelman B.M. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol. Cell 6 (2000) 307-316
43. Hagemeier C., Cook A., and Kouzarides T. The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res. 21 (1993) 4998-5004
44. Zhang H.S., Gavin M., Dahiya A., Postigo A.A., Ma D., Luo R.X., Harbour J.W., and Dean D.C. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-rb-hSWI/SNF and rb-hSWI/SNF. Cell 101 (2000) 79-89
45. Sakai Y., Saijo M., Coelho K., Kishino T., Niikawa N., and Taya Y. CDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product. Genomics 30 (1995) 98-101
46. Simons A., Melamed-Bessudo C., Wolkowicz R., Sperling J., Sperling R., Eisenbach L., and Rotter V. PACT: Cloning and characterization of a cellular p53 binding protein that interacts with rb. Oncogene 14 (1997) 145-155
47. Witte M.M., and Scott R.E. The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. Proc. Natl. Acad. Sci. USA 94 (1997) 1212-1217
48. St-Pierre B., Liu X., Kha L.C., Zhu X., Ryan O., Jiang Z., and Zacksenhaus E. Conserved and specific functions of mammalian ssu72. Nucleic Acids Res. 33 (2005) 464-477
49. Ahlander J., and Bosco G. Sqd interacts with the Drosophila retinoblastoma tumor suppressor Rbf. Biochem. Biophys. Res. Commun. 383 (2009) 363-367