Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis

Phytotherapy Research

Volumn 23, Issue 5, 2009, Pages 707-712

  Trinchero, Juan ^a   Ponce, Nora M A ^b,c   Córdoba, Osvaldo L ^b   Flores, María L ^b   Pampuro, Sandra ^a   Stortz, Carlos A ^c   Salomón, Horacio ^a   Turk, Gabriela ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DE LA PATAGONIA SAN JUAN BOSCO   (Argentina)

^c DEPARTAMENTO DE QUÍMICA ORGÁNICA   (Argentina)

Author keywords

Antiviral activity; Brown seaweeds; Fucoidans; HIV

Indexed keywords

FUCOIDIN; GALACTOFUCAN; UNCLASSIFIED DRUG; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PLANT EXTRACT; POLYSACCHARIDE;

ADENOCYSTIS UTRICULARIS; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL WALL; CONTROLLED STUDY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SEAWEED; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS RESISTANCE; BROWN ALGA; CELL LINE; CHEMISTRY; DRUG EFFECT; PHYSIOLOGY;

ADENOCYSTIS UTRICULARIS; HUMAN IMMUNODEFICIENCY VIRUS 1; SIMPLEXVIRUS;

ALGAE, BROWN; ANTI-HIV AGENTS; CELL LINE; CELL WALL; HIV-1; HUMANS; PLANT EXTRACTS; POLYSACCHARIDES; SEAWEED; VIRUS REPLICATION;

EID: 65649117264     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2723     Document Type: Article

References (31)

1. Baba M, Schols D, De Clercq E et al. 1990. Novel sulfated polymers as highly potent and selective inhibitors of human immunodeficiency virus replication and giant cell formation. Antimicrob Agents Chemother 34: 134-138.
2. Balzarini J, Van Damme L. 2007. Microbicide drug candidates to prevent HIV infection. Lancet 369: 787-797.
3. Beress A, Wassermann O, Tahhan S et al. 1993. A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus vesiculosus. J Nat Prod 56: 478-488.
4. Callahan LN, Phelan M, Mallinson M, Norcross MA. 1991. Dextran sulfate blocks antibody binding to the principal neutralizing domain of human immunodeficiency virus type 1 without interfering with gp120-CD4 interactions. J Virol 65: 1543-1550.
5. Chevolot L, Foucault A, Chaubet F et al. 1999. Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity. Carbohydr Res 319: 154-165.
6. Cos P, Maes L, Vanden Berghe D, Hermans N, Pieters L, Vlietinck A. 2004. Plant substances as anti-HIV agents selected according to their putative mechanism of action. J Nat Prod 67: 284-293.
7. Damonte EB, Pujol CA, Coto CE. 2004. Prospects for the therapy and prevention of dengue virus infections. Adv Virus Res 63: 239-285.
8. Duarte ME, Cardoso MA, Noseda MD, Cerezo AS. 2001. Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum. Carbohydr Res 333: 281-293.
9. Feldman SC, Reynaldi S, Stortz CA, Cerezo AS, Damonte EB. 1999. Antiviral properties of fucoidan fractions from Leathesia difformis. Phytomedicine 6: 335-340.
10. Fernandez-Romero JA, Thorn M, Turville SG et al. 2007. Carrageenan/MIV-150 (PC-815), a combination microbicide. Sex Transm Dis 34: 9-14.
11. Harrop HA, Coombe DR, Rider CC. 1994. Heparin specifically inhibits binding of V3 loop antibodies to HIV-1 gp120, an effect potentiated by CD4 binding. AIDS 8: 183-192.
12. Hart CA, Evans-Strickfaden T. 2007. HIV entry inhibitors as microbicides. In Entry Inhibitors in HIV Therapy, Reeves JD (ed.). Birkhauser: Basel, 99-117.
13. Hoffmann C, Rockstroh JK, Kamps BD. 2006. HIV Medicine 2006. Flying Publisher: Paris, 818.
14. Hoshino T, Hayashi T, Hayashi K, Hamada J, Lee JB, Sankawa U. 1998. An antivirally active sulfated polysaccharide from Sargassum horneri (Turner) C. Agardh. Biol Pharm Bull 21: 730-734.
15. Kilmarx PH, van de Wijgert JH, Chaikummao S et al. 2006. Safety and acceptability of the candidate microbicide Carraguard in Thai women: findings from a phase II clinical trial. J Acquir Immune Defic Syndr 43: 327-334.
16. Kolender AA, Pujol CA, Damonte EB, Matulewicz MC, Cerezo AS. 1997. The system of sulfated alpha-(1->3)-linked D-mannans from the red seaweed Nothogenia fastigiata: structures, antiherpetic and anticoagulant properties. Carbohydr Res 304: 53-60.
17. Moen LK, Clark GF. 1993. A novel reverse transcriptase inhibitor Fucus vesiculosus. Int Conf AIDS 9: 145-161.
18. Nakashima H, Inazawa K, Ichiyama M et al. 1995. Sulfated alkyl oligosaccharides inhibit human immunodeficiency virus in vitro and provide sustained drug levels in mammals. Antiviral Chem Chemother 6: 271-280.
19. Nishino T, Nagumo T. 1991. The sulfate-content dependence of the anticoagulant activity of a fucan sulfate from the brown seaweed Ecklonia kurome. Carbohydr Res 214: 193-197.
20. Nishino T, Nagumo T. 1992. Anticoagulant and antithrombin activities of oversulfated fucans. Carbohydr Res 229: 355-362.
21. Nishino T, Nagumo T, Kiyohara H, Yamada H. 1991. Structural characterization of a new anticoagulant fucan sulfate from the brown seaweed Ecklonia kurome. Carbohydr Res 211: 77-90.
22. Nishino T, Nishioka C, Ura H, Nagumo T. 1994. Isolation and partial characterization of a novel amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan. Carbohydr Res 255: 213-224.
23. Pauwels R, De Clercq E. 1996. Development of vaginal microbicides for the prevention of heterosexual transmission of HIV. J Acquir Immune Defic Syndr Hum Retrovirol 11: 211-221.
24. Ponce NMA. 2007. Estudio del sistema de polisacáridos de Adenocystis utricularis, un alga parda de las costas patagónicas argentinas de posible utilización farmacológica y/o industrial. PhD Thesis. Facultad de Ciencias Naturales, Universidad Nacional de la Patagonia San Juan Bosco, Comodoro Rivadavia.
25. Ponce NM, Pujol CA, Damonte EB, Flores ML, Stortz CA. 2003. Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies. Carbohydr Res 338: 153-165.
26. Renn DW. 1993. Medical and biotechnological applications of marine macroalgal polysaccharides. In Marine Biotechnology, Vol.1, Attaway DH, Oskar R (eds). Plenum Press: New York, 191-196.
27. Schaeffer DJ, Krylov VS. 2000. Anti-HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicol Environ Saf 45: 208-227.
28. Venkateswaran PS, Millman I, Blumberg BS. 1989. Interaction of fucoidan from Pelvetia fastigiata with surface antigens of hepatitis B and woodchuck hepatitis viruses. Planta Med 55: 265-270.
29. Whitehead SJ, Kilmarx PH, Blanchard K et al. 2006. Acceptability of Carraguard vaginal gel use among Thai couples. AIDS 20: 2141-2148.
30. Witvrouw M, De Clercq E. 1997. Sulfated polysaccharides extracted from sea algae as potential antiviral drugs. Gen Pharmacol 29: 497-511.
31. Zhuang C, Itoh H, Mizuno T, Ito H. 1995. Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii). Biosci Biotechnol Biochem 59: 563-567.