Compounds binding to the S2-S3 pockets of thrombin

Journal of Medicinal Chemistry

Volumn 52, Issue 9, 2009, Pages 2708-2715

  Nilsson, Mikael ^a,d   Hämäläinen, Markku ^b   Ivarsson, Maria ^b   Gottfries, Johan ^c   Xue, Yafeng ^c   Hansson, Sebastian ^c   Isaksson, Roland ^a   Fex, Tomas ^c  

^a LINNAEUS UNIVERSITY   (Sweden)

^b GE Healthcare Bio Sciences AB   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d Cambrex Karlskoga AB Sweden   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; PROLINE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THROMBIN;

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; HYDROGEN BOND; IC 50; LIPOPHILICITY; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; X RAY ANALYSIS;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN BINDING; SERINE PROTEINASE INHIBITORS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 65649111669     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8011849     Document Type: Article

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