LDI-PCR: Identification of known and unknown gene fusions of the human MLL gene

Methods in Molecular Biology

Volumn 538, Issue , 2009, Pages 71-83

  Meyer, Claus ^a   Marschalek, Rolf ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Acute leukemia; Chromosomal translocations; Fusion partner genes; Genetic rearrangements; Genomic DNA; LDI PCR; MLL; Molecular marker; MRD

Indexed keywords

MIXED LINEAGE LEUKEMIA PROTEIN; MLL PROTEIN, HUMAN; ONCOPROTEIN;

ARTICLE; GENETICS; HUMAN; LEUKEMIA; METHODOLOGY; POLYMERASE CHAIN REACTION;

HUMANS; LEUKEMIA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION;

EID: 65649108608     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-418-6_5     Document Type: Article

References (16)

1. Gu, Y., Nakamura, T., Alder, H., Prasad, R., Canaani, O., Cimino, G., et al. (1992) The t(4;11) chromosome translocation of human acute leukemias fuses the ALL -1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71, 701-708.
2. Tkachuk, D. C., Kohler, S., Cleary, M. L. (1992) Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71, 691-700.
3. Meyer, C., Schneider, B., Reichel, M., Anger- müller, S., Strehl, S., Schnittger, S., et al. (2005) A new diagnostic tool for the iden tification of MLL rearrangements including unknown partner genes. Proc. Natl. Acad. Sci. USA 102, 449-454. (Pubitemid 40116787)
4. Meyer, C., Schneider, B., Jakob, S., Strehl, S., Schnittger, S., Schoch, C., et al. (2006) The MLL recombinome of acute leukemias. Leukemia 20, 777-784.
5. Meyer, C., Kowarz, E., Schneider, B., Oehm, C., Klingebiel, T., Dingermann, T., et al. (2006) Genomic DNA of leukemia patients: target for clinical diagnosis of MLL rearrange ments. Biotechnol. J. 1, 656-663.
6. Estable, M. C., Naghavi, M. H., Kato, H., Xiao, H., Qin, J., Vahlne, A., et al. (2002) MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein. J. Biomed. Sci. 9, 234-245. (Pubitemid 34639032)
7. Zeisig, D. T., Bittner, C. B., Zeisig, B. B., Garcia-Cuellar, M. P., Hess, J. L., and Slany, R. K. (2005) The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene 24, 5525-5532. (Pubitemid 43080096)
8. Bitoun, E., Oliver, P. L., and Davies, K. E. (2007) The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum. Mol. Genet. 16, 92-106. (Pubitemid 46152547)
9. Felix, C. A., Kim, C. S., Megonigal, M. D., Slater, D. J., Jones, D. H., Spinner, N. B., et al. (1997) Panhandle polymerase chain reaction amplifies MLL genomic translocation breakpoint involving unknown partner gene. Blood 90, 4679-4686. (Pubitemid 28007179)
10. Jones, D. H., Winistorfer, S. C. (1992) Sequence specific generation of a DNA panhandle permits PCR amplification of unknown flanking DNA. Nucleic Acids Res. 20, 595-600.
11. Burmeister, T., Marschalek, R., Schneider, B., Meyer, C., Gökbuget, N., Schwartz, S., et al. (2006) Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations. Leukemia 20, 451-457. (Pubitemid 43291743)
12. Reichel, M., Gillert, E., Angermüller, S., Hensel, J. P., Heidel, F., Lode, M., et al. (2001) Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL. Oncogene 20, 2900-2907. (Pubitemid 33027757)
13. Langer, T., Metzler, M., Reinhardt, D., Viehmann, S., Borkhardt, A., Reichel, M., et al. (2003) Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides. Genes Chrom. Cancer 36, 393-401. (Pubitemid 36314522)
14. Ochman, H., Gerber, A. S., and Hartl, D. L. (1988) Genetic applications of an inverse polymerase chain reaction. Genetics 120, 621-623. (Pubitemid 18260496)
15. Reichel, M., Gillert, E., Nilson, I., Siegler, G., Greil, J., Fey, G. H., et al. (1998) Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation. Oncogene 17, 3035-3044. (Pubitemid 29012207)
16. Gillert, E., Leis, T., Repp, R., Reichel, M., Hösch, A., Breitenlohner, I., et al. (1999) A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells. Oncogene 18, 4663-4671. (Pubitemid 29417741)