Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits

European Review for Medical and Pharmacological Sciences

Volumn 13, Issue 2, 2009, Pages 95-98

  Uzun, Metehan ^a   Alp, R ^b   Uzlu, E ^b   Alp, S ^c   Citil, M ^b   Topcu, B ^b   Erdogan, H M ^b  

^a ÇANAKKALE ONSEKIZ MART UNIVERSITY   (Turkey)

^b KAFKAS UNIVERSITY   (Turkey)

^c Kars State Hospital   (Turkey)

Author keywords

ECG; QT; Rabbit; Rasagilin; Selegiline

Indexed keywords

RASAGILINE; SELEGILINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONSCIOUSNESS; CONTROLLED STUDY; CORRECTED QT VALUE; DRUG EFFECT; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY; EVENING DOSAGE; FEMALE; HEART RATE; LONG TERM CARE; MALE; MORNING DOSAGE; NONHUMAN; QT INTERVAL; QT PROLONGATION; RABBIT;

ADMINISTRATION, ORAL; ANIMALS; ANTIPARKINSON AGENTS; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; INDANS; LONG QT SYNDROME; MALE; MONOAMINE OXIDASE INHIBITORS; PARKINSON DISEASE; RABBITS; SELEGILINE; TIME FACTORS;

EID: 65649106904     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. GUAY DR. Rasagiline (TVP-1012): A new selective monoamine oxidase Inhibitor for Parkinson's disease. Am J Geriatr Pharmacother 2006; 4:330-346.
2. REYNOLDS GP ELSWORTH JD, BLAU K, SANDLER M, LEES AJ, STERN GM. Deprenyl is metabolized to methamphetamine and amphetamine in man. Br J Clin Pharmacol 1978; 6: 542-544.
3. GILL JR, MASON DT, BARTTER F. Effects of hydroxyamphetamine on the function of sympathetic nervous system in normotensive subject. J Pharmacol Exp Ther 1967; 155: 288-295.
4. CAVANAUGH JH, GRIFFITH JD, OATES JA. Effect of amphetamine on the pressor response to tyramine: Formation of p-hydroxynorephedrine from amphetamine in man. Clin Pharmacol Ther 1970; 11: 656-664.
5. YASAR S, GOLDBERG JP, GOLDBERG SR. Are metabolites of I-deprenyl (selegiline) useful or harmful? Indications from preclinical research. J Neural Transm Suppl 1996; 48: 61-73.
6. KAYE S, MCKETIN R, DUFLOU J, DARKE S. Metamphetamine and cardiovascular patholgy: A review of the evidence. Addiction 2007; 102:1204-1211.
7. YAP YG, CAMM J. Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation. Br Med J 2000; 320:1158-1159.
8. UZUN M, YAPAR K, UZLU E, CITIL M, ERDOGAN HM. QT interval prolongation and decreased heart rates after intravenous bolus oxytocin injection in male and female conscious rabbits. Gen Physiol Biophys 2007; 26:168-172.
9. FRIDERICIA LS. Die systolendouer im Elektrokardiogramm bei normalen Menschen und bei Horzkranken. Acta Med Scand 1920; 53, 489.
10. ABASSI ZA, BINAH O, YOUDIM MB. Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: Comparison with selegiline. Brit J Pharmacol 2004; 143: 371-378.
11. FINBERG JPM, GROSS A, BAR-AM O, FRIEDMAN R, LOBODA Y, YOUDIM MBH. Cardiovascular responses to combined treatment with selective monoamine oxidase type B inhibitors and L-DOPA in the rat. Brit J Pharmacol 2006; 149: 647-656.
12. CHURCHYARD A, MATHIAS CJ, BOONKONGCHUEN P LEES AJ. Autonomic effects of selegiline: Possible cardiovascular toxicity in Parkinson's disease. J Neurol Neurosurg Psychiatry 1997; 63: 228-234.
13. HANING W, GOEBERT D. Electrocardiographic abnormalities in methamphetamine abusers. Addiction 2007; 102 (Suppl 1): 70-75
14. OKA H, MOCHIO S, SATO H, KATAYAMA K. Prolongation of QTc interval in patients with Parkinson's disease. Eur Neurol 1997; 37:186-189.
15. YEE KM, LIM PO, OGSTON SA, STRUTHERS AD. Effect of phenylephrine with and without atropine on QT dispersion in healthy normotensive men. Am J Cardiol 2000; 85: 69-74.