High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects

Clinical and Experimental Dermatology

Volumn 34, Issue 4, 2009, Pages 500-508

  Cho, S ^a   Choi, C W ^a   Lee, D H ^a   Won, C H ^a   Kim, S M ^b   Lee, S ^a,b   Lee, M J ^a,b   Chung, J H ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIMER; DNA; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PROCOLLAGEN; SEMOSQUALENE; SQUALENE; THYMINE; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIMERIZATION; DNA DAMAGE; DRUG MEGADOSE; FACE ERYTHEMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LOOSE FECES; LOW DRUG DOSE; NORMAL HUMAN; PHOTOAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK BENEFIT ANALYSIS; SIDE EFFECT; SKIN BIOPSY; SKIN PIGMENTATION; STEATORRHEA; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; ULTRAVIOLET RADIATION; VITAMIN SUPPLEMENTATION; WEIGHT REDUCTION; WRINKLE;

AGED; COLLAGEN TYPE I; DIARRHEA; DIETARY SUPPLEMENTS; DNA DAMAGE; FEMALE; HUMANS; MATRIX METALLOPROTEINASE 1; MIDDLE AGED; SKIN AGING; SKIN PIGMENTATION; SQUALENE; STEATORRHEA; TREATMENT OUTCOME; ULTRAVIOLET RAYS;

EID: 65649098071     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2008.03133.x     Document Type: Article

References (21)

1. Liu GC, Ahrens EH Jr., Schreibman PH, Crouse J. Measurement of squalene in human tissues and plasma: validation and application. J Lipid Res 1976 17 : 38 45.
2. Strandberg TETR, Miettinen TA. Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. J Lipid Res 1990 31 : 1637 43. (Pubitemid 20321724)
3. Miettinen TAVH. Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. Am J Clin Nutr 1994 59 : 356 63.
4. Gylling H, Miettinen TA. Postabsorptive metabolism of dietary squalene. Atherosclerosis 1994 106 : 169 78. (Pubitemid 24188759)
5. Kohno Y, Egawa Y, Itoh S et al. Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol. Biochim Biophys Acta 1995 1256 : 52 6.
6. Asnis DS, Saltzman HP, Melchert A. Shark oil pneumonia. An overlooked entity. Chest 1993 103 : 976 7. (Pubitemid 23086223)
7. Kamimura H, Koga N, Oguri K et al. Studies on distribution, excretion and subacute toxicity of squalane in dogs Fukuoka Igaku Zasshi 1989 80 : 269 80. (Pubitemid 19165490)
8. Kelly GS. Squalene and its potential clinical uses. Altern Med Rev 1999 4 : 29 36. (Pubitemid 29205159)
9. McG J Jr., Lipsky SR. The effects of squalene on the incorporation of acetate into plasma cholesterol in man. J Clin Invest 1955 34 : 704 10.
10. Chan P, Tomlinson B, Lee CB, Lee YS. Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. J Clin Pharmacol 1996 36 : 422 7. (Pubitemid 26165735)
11. Yamaguchi T, Nakagawa M, Hidaka K et al. Potentiation by squalene of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-1-(2- chloroethyl)-nitrosourea in a murine tumor system. Jpn J Cancer Res 1985 76 : 1021 6. (Pubitemid 16198828)
12. Kamimura H, Koga N, Oguri K, Yoshimura H. Enhanced elimination of theophylline, phenobarbital and strychnine from the bodies of rats and mice by squalane treatment. J Pharmacobiodyn 1992 15 : 215 21.
13. Fisher GJ, Wang ZQ, Datta SC et al. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 1997 337 : 1419 28. (Pubitemid 27497889)
14. Varani J, Warner RL, Gharaee-Kermani M et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000 114 : 480 6. (Pubitemid 30415333)
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods 2001 25 : 402 8. (Pubitemid 34164012)
16. Strandberg TE, Tilvis RS, Miettinen TA. Variations of hepatic cholesterol precursors during altered flows of endogenous and exogenous squalene in the rat. Biochim Biophys Acta 1989 1001 : 150 6. (Pubitemid 19050077)
17. Lewkowicz P, Banasik M, Glowacka E et al. Effect of high doses of shark liver oil supplementation on T cell polarization and peripheral blood polymorphonuclear cell function Pol Merkur Lekarski 2005 18 : 686 92. (Pubitemid 40942503)
18. Hayashi N, Togawa K, Yanagisawa M et al. Effect of sunlight exposure and aging on skin surface lipids and urate. Exp Dermatol 2003 12 (Suppl. 2 13 17. (Pubitemid 37526843)
19. Yamamoto Y. Role of active oxygen species and antioxidants in photoaging. J Dermatol Sci 2001 27 (Suppl. 1 S1 4. (Pubitemid 32757175)
20. Ohsawa K, Watanabe T, Matsukawa R et al. The possible role of squalene and its peroxide of the sebum in the occurrence of sunburn and protection from the damage caused by U.V. irradiation. J Toxicol Sci 1984 9 : 151 9. (Pubitemid 14087285)
21. Cooper MF, McGrath H, Shuster S. Sebaceous lipogenesis in human skin. Variability with age and with severity of acne. Br J Dermatol 1976 94 : 165 72.