NMR and molecular dynamics study of the binding mode of naphthalene-N-sulfonyl-d-glutamic acid derivatives: Novel MurD ligase inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 9, 2009, Pages 2899-2908

  Simčić, Mihael ^a   Hodošček, Milan ^a   Humljan, Jan ^b   Kristan, Katja ^b   Urleb, Uroš ^b   Kocjan, Darko ^a,b   Grdadolnik, Simona Golič ^a  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^b Lek dd   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; DEXTRO GLUTAMIC ACID; ENZYME INHIBITOR; NAPHTHALENE N SULFONYL DEXTRO GLUTAMIC ACID DERIVATIVE; PROTEIN MURD; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG CONFORMATION; EPITOPE MAPPING; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PARAMETER; SATURATION TRANSFER DIFFERENCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

DRUG DESIGN; ENZYME INHIBITORS; EPITOPE MAPPING; ESCHERICHIA COLI; GLUTAMIC ACID; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; NAPHTHALENES; PEPTIDE SYNTHASES; PROTEIN BINDING;

EID: 65649094038     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900117n     Document Type: Article

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