Human cytomegalovirus-specific T cell reconstitution in young patients receiving T cell-depleted, allogeneic hematopoietic stem cell transplantation

Journal of Infectious Diseases

Volumn 199, Issue 6, 2009, Pages 829-836

  Lilleri, Daniele ^a   Gerna, Giuseppe ^a,d   Fornara, Chiara ^a   Chiesa, Antonella ^a   Comolli, Giuditta ^a,b   Zecca, Marco ^c   Locatelli, Franco ^c  

^a Servizio di Virologia   (Italy)

^b Laboratori Sperimentali di Ricerca   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CYCLOSPORIN A; GAMMA INTERFERON; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; DENDRITIC CELL; FEMALE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNE RECONSTITUTION; INCIDENCE; INFECTION CONTROL; MALE; MYELOABLATIVE CONDITIONING; NEURITIS; PHOTOCHEMOTHERAPY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; VIRUS REACTIVATION;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LYMPHOCYTE DEPLETION; MALE; RECURRENCE; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 65649089024     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/597123     Document Type: Article

References (42)

1. Rocha V, Locatelli F. Searching for alternative hematopoietic stem cell donors for pediatric patients. Bone Marrow Transplant 2008; 41:207-14.
2. Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339:1186-93.
3. Ball LM, Lankester AC, Bredius RGM, Fibbe WE, van Tol MJD, Egeler RM. Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 35:S35-8.
4. Boeckh M, Ljungman P. Cytomegalovirus infection after bone marrow transplantation. In: Paya C, ed: Transplant infections. Philadelphia: Lippincott-Raven, 1998:215-27.
5. Locatelli F, Percivalle E, Comoli P, et al. Human cytomegalovirus (HCMV) infection in paediatric patients given allogeneic bone marrow transplantation: role of early antiviral treatment for HCMV antigenaemia on patients' outcome. Br J Haematol 1994; 88:64-71.
6. BoeckhM,Gooley TA, Myerson D,CunninghamT, Schoch G,BowdenRA. Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclo- vir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study. Blood 1996; 88:4063-71.
7. Quinnan GV Jr, Kirmani N, Rook AH, et al. Cytotoxic T cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-Tlymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients. N Engl J Med 1982; 307:7-13.
8. Reusser P, Riddell SR, Meyers JD, Greenberg PD. Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease. Blood 1991; 78:1373-80.
9. Li CR, Greenberg PD, Gilbert MJ, Goodrich JM, Riddell SR. Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: correlation with CMV disease and effect of ganciclovir prophylaxis. Blood 1994; 83:1971-9.
10. Altman JD, Moss PAH, Goulder PJR, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996; 274:94-6.
11. WaldropSL, Pitcher CJ, PetersonDM,MainoVC,Picker LJ. Determination of antigen-specific memory/effector CD4- T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 1997; 99:1739-50.
12. Cwynarski K, Ainsworth J, Cobbold M, et al. Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation. Blood 2001; 97:1232-40.
13. Gratama JW, van Esser JWJ, Lamers CHJ, et al. Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8- T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressiveCMVinfection. Blood 2001; 98:1358-64.
14. Mohti M, Mohti AM, Blaise D, et al. Cytomegalovirus-specific immune recovery following allogeneic HLA identical sibling transplantation with reduced-intensity preparative regimen. Bone Marrow Transplant 2004; 33:839-46.
15. Lozza L, Lilleri D, Percivalle E, et al. Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4- and CD8- T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells. Eur J Immunol 2005; 35:1795-804.
16. Lilleri D, Zelini P, Fornara C, Comolli G, Gerna G. Inconsistent responses of cytomegalovirus-specific T cells to pp65 and IE-1 versus infected dendritic cells in organ transplant recipients. Am J Transplant 2007; 7:1997-2005.
17. Lilleri D, Gerna G, Fornara C, Lozza L, Maccario R, Locatelli F. Prospective simultaneous quantification of human cytomegalovirus-specific CD4- and CD8- T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplantation. Blood 2006; 108:1406-12.
18. Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graftversus- host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18:295-304.
19. Storb R, Prentice RL, Sullivan KM, et al. Predictive factors in chronic graft-versus-host disease in patients with aplastic anemia treated by marrow transplantation from HLA-identical siblings. Ann Intern Med 1983; 98:461-6.
20. Salvaneschi L, Perotti C, Zecca M, et al. Extracorporeal photochemotherapy for treatment of acute and chronic GVHD in childhood. Transfusion 2001; 41:1299-305.
21. Ljungman P, Griffiths P, Paya C. Definition of HCMV infection and disease in transplant recipients. Clin Infect Dis 2002; 34:1094-7.
22. Gerna G, Revello MG, Percivalle E, Morini F. Comparison of different immunostaining techniques and monoclonal antibodies to the lower matrix phosphoprotein (pp65) for optimal quantitation of human cytomegalovirus antigenemia. J Clin Microbiol 1992; 30:1232-7.
23. Gerna G, Vitulo P, Rovida F, et al. Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on lower respiratory tract infections of lung transplant recipients. J Med Virol 2006; 78:408-16.
24. Lilleri D, Gerna G, Furione M, et al. Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving haematopoietic stem-cell transplantation compared with qualitative pp65 antigenemia. Blood 2007; 110:2757-60.
25. Gerna G, Revello MG, Percivalle E, Torsellini M. A 6-h microneutralization assay for human cytomegalovirus antibody by using monoclonal antibodies. Serodiagn Immunother Infect Dis 1990; 4:243-7.
26. Gerna G, Sarasini A, Patrone M, et al. Human cytomaglovirus neutralizing antibodies block virus infection of endothelial/epithelial cells, but not fibroblasts, early during viral infection. J Gen Virol 2008; 89:853-65.
27. Gooley TA, Leisenring W, Crowley J, Storer BE. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 1999; 18:695-706.
28. Klein JP, Rizzo JD, Zhang M-J, Keiding N. Statistical methods for analysis and presentation of the results of bone marrow transplants, part I: unadjusted analysis. Bone Marrow Transplant 2001; 28:909-15.
29. Seckert CK, Renzaho A, Reddehase MJ, Grzimek NK. Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection. Med Microbiol Immunol 2008; 197:251-9.
30. Lilleri D, Fornara C, Chiesa A, Caldera D, Alessandrino EP, Gerna G. Human cytomegalovirus-specific CD4- and CD8- T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection. Haematologica 2008; 93:248-56.
31. Gratama JW, Zwaan FE, Stijnen T. Herpes-virus immunity and acute graft-versus-host disease. Lancet 1987; 1:471-4.
32. Grundy JE, Shanley JD, Shearer GM. Augmentation of graft-versus-host reaction by cytomegalovirus infection resulting in interstitial pneumonitis. Transplantation 1985; 39:548-53.
33. Boström L, Ringdén O, Gratama JW, et al.Arole of herpes virus serology for the development of acute graft-versus-host disease. Leukaemia Working Party of the European Group for Bone Marrow Transplantation. Bone Marrow Transplant 1990; 5:321-6.
34. Broers AE, van Der Holt R, van Esser JW. Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell-depleted stem cell transplantation. Blood 2000; 95:2240-5.
35. Meijer E, Dekker AW, Rozenberg-Arska M, Weersink AJ, Verdonck LF. Influence of cytomegalovirus seropositivity on outcome after T cell- depleted bone marrow transplantation: contrasting results between recipients of grafts from related and unrelated donors. Clin Infect Dis 2002; 35:703-12.
36. Chalandon Y, Degermann S, Villard J, et al. Pretransplantation CMVspecific T cells protect recipients of T-cell-depleted grafts against CMVrelated complications. Blood 2006; 107:389-96.
37. Montagna D, Locatelli F, Moretta A, et al. T lymphocytes of recipient origin may contribute to the recovery of specific immune response towards viruses and fungi in children given cord blood transplantation. Blood 2004; 103:4322-9.
38. Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4- T-lymphocyte regeneration after intensive chemotherapy.NEngl J Med 1995; 332:143-9.
39. Roux E, Dumont-Girard F, Starobinski M, et al. Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity. Blood 2000; 96:2299-303.
40. Ozdemir E, St John LS, Gillespie G, et al. Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8- T cells. Blood 2002; 100:3690-7.
41. Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol 2004; 78:5535-45.
42. Perruccio K, Tosti A, Burchielli E, et al. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 2005; 106:4397-406.