Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 3081-3084

  Attenni, Barbara ^a   Ontoria, Jesus M ^a   Cruz, Jonathan C ^b   Rowley, Michael ^a   Schultz Fademrecht, Carsten ^a   Steinkühler, Christian ^a   Jones, Philip ^a  

^a IRBM   (Italy)

^b MRL Boston   (United States)

Author keywords

HDAC inhibitors; Primary carboxamide; Zinc binding group

Indexed keywords

AMIDE; APICIDIN; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; VORINOSTAT; ZINC BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SCREENING; NONHUMAN;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MICE; MICE, NUDE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS; ZINC;

EID: 65549166943     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.011     Document Type: Article

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