Detection of immunoglobulin g human leukocyte antigen-specific alloantibodies in renal transplant patients using single-antigen-beads is compromised by the presence of immunoglobulin m human leukocyte antigen-specific alloantibodies

Transplantation

Volumn 87, Issue 6, 2009, Pages 813-820

  Kosmoliaptsis, Vasilis ^a,b   Bradley, J Andrew ^b   Peacock, Sarah ^a   Chaudhry, Afzal N ^c   Taylor, Craig J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Allosensitisation; HLA specific antibody; IgG; IgM; Single antigen beads

Indexed keywords

ALLOANTIBODY; HLA ANTIBODY; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; MONOCLONAL ANTIBODY; HLA ANTIGEN;

ACUTE GRAFT REJECTION; ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HLA SYSTEM; HUMAN; HYPERACUTE GRAFT REJECTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; ORGAN TRANSPLANTATION; PATIENT MONITORING; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; SENSITIZATION; SERUM; SINGLE ANTIGEN BEAD; TECHNOLOGY; TREATMENT OUTCOME; ANTIBODY SPECIFICITY; BLOOD; IMMUNOLOGY;

ANTIBODY SPECIFICITY; HLA ANTIGENS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; ISOANTIBODIES; KIDNEY TRANSPLANTATION;

EID: 65549166852     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318199c581     Document Type: Article

References (23)

1. Taylor CJ, Chapman JR, Ting A, et al. Characterisation of lymphocytotoxic antibodies causing a positive crossmatch in renal transplantation: Relationship to primary and regraft outcome. Transplantation 1989; 48: 953.
2. Fuggle SV, Martin S. Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patients. Transplantation 2008; 86: 384.
3. Cecka JM, Zhang Q, Reed EF. Preformed cytotoxic antibodies in potential allograft recipients: Recent data. Hum Immunol 2005; 66: 343.
4. Gibney EM, Cagle LR, Freed B, et al. Detection of donor-specific antibodies using HLA-coated microspheres: Another tool for kidney transplant risk stratification. Nephrol Dial Transplant 2006; 21: 2625.
5. Reinsmoen NL, Lai CH, Vo A, et al. Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy. Transplantation 2008; 86: 820.
6. Zachary AA, Montgomery RA, Leffell MS. Factors associated with and predictive of persistence of donor-specific antibody after treatment with plasmapheresis and intravenous immunoglobulin.HumImmunol 2005; 66: 364.
7. Pei R, Lee JH, Shih NJ, et al. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 2003; 75: 43.
8. Pei R, Wang G, Tarsitani C, et al. Simultaneous HLA class I and class II antibodies screening with flow cytometry.HumImmunol 1998; 59: 313.
9. Pei R, Lee J, Chen T, et al. Flow cytometric detection of HLA antibodies using a spectrum of microbeads. Hum Immunol 1999; 60: 1293.
10. Mizutani K, Terasaki P, Hamdani E, et al. The importance of anti- HLA-specific antibody strength in monitoring kidney transplant patients. Am J Transplant 2007; 7: 1027.
11. Vaidya S. Clinical importance of anti-human leukocyte antigen-specific antibody concentration in performing calculated panel reactive antibody and virtual crossmatches. Transplantation 2008; 85: 1046.
12. Issa N, Cosio FG, Gloor JM, et al. Transplant glomerulopathy: Risk and prognosis related to anti-human leukocyte antigen class II antibody levels. Transplantation 2008; 86: 681.
13. Terasaki PI, Cai J. Human leukocyte antigen antibodies and chronic rejection: From association to causation. Transplantation 2008; 86: 377.
14. Eckels DD. Solid phase testing in the HLA laboratory: Implications for organ allocation. Int J Immunogenet 2008; 35: 265.
15. Claas FHJ. HLA antibody testing: A tool to facilitate not to prevent organ transplantation. Int J Immunogenet 2008; 35: 275.
16. Goodman RS, Taylor CJ, O'Rourke CM, et al. Utility of HLAMatchmaker and single-antigen HLA antibody detection beads for identification of acceptable mismatches in highly sensitized patients awaiting kidney transplantation. Transplantation 2006; 81: 1331.
17. El-Awar N, Lee J, Tarsitani C, et al. HLA class I epitopes: Recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Hum Immunol 2007; 68: 170.
18. Kosmoliaptsis V, Bradley JA, Sharples LD, et al. Predicting the immunogenicity of human leukocyte antigen class I alloantigens using structural epitope analysis determined by HLAMatchmaker. Transplantation 2008; 85: 1817.
19. El-Awar NR, Akaza T, Terasaki PI, et al. Human leukocyte antigen class I epitopes: Update to 103 total epitopes, including the C locus. Transplantation 2007; 84: 532.
20. Sparks K, Ballow M. The indirect ELISA for quantitation of specific antibody: Analysis of antibody dilution curves. Diagn Immunol 1983; 1: 269.
21. Vos Q, Klasen EA, Haaijman JJ. The effect of divalent and univalent binding on antibody titration curves in solid-phase ELISA. J Immunol Methods 1987; 103: 47.
22. Linder E, Miettinen A. Prozone effects in indirect immunofluorescence. Scand J Immunol 1976; 5: 513.
23. Ten Hoor G, Coopmans M, Allebes W. Specificity and IgG class of preformed alloantibodies causing a positive crossmatch in renal transplantation. Transplantation 1993; 56: 298.