Future demographic trends decrease the proportion of ischemic stroke patients receiving thrombolytic therapy: A call to set-up therapeutic studies in the very old

Stroke

Volumn 40, Issue 5, 2009, Pages 1900-1902

  Foerch, Christian ^a   Sitzer, Matthias ^a,b   Steinmetz, Helmuth ^a   Neumann Haefelin, Tobias ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Department of Neurology ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR;

AGE DISTRIBUTION; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE REGISTRY; FEMALE; FIBRINOLYTIC THERAPY; GERMANY; HOSPITALIZATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; SEX DIFFERENCE; BRAIN ISCHEMIA; FORECASTING; MIDDLE AGED; PROSPECTIVE STUDY; REGISTER; STATISTICS; STROKE;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; FORECASTING; GERMANY; HUMANS; MALE; MIDDLE AGED; PLASMINOGEN ACTIVATORS; PROSPECTIVE STUDIES; REGISTRIES; SEX FACTORS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 65549165815     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.531061     Document Type: Article

References (16)

1. Population projections 2004-2050. Eurostat News Release. 2005.
2. Eisenmenger M, Potzsch O, Sommer B. Bevolkerung Deutschlands bis 2050. Statistisches Bundesamt. 2006.
3. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333:1581-1587.
4. Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology. 2001;56:1015-1020.
5. Foerch C, Misselwitz B, Sitzer M, Berger K, Steinmetz H, Neumann-Haefelin T. Difference in recognition of right and left hemispheric stroke. Lancet. 2005;366:392-393.
6. Foerch C, Misselwitz B, Sitzer M, Steinmetz H, Neumann-Haefelin T. The projected burden of stroke in the German Federal State of Hesse up to the year 2050. Dtsch Arztebl. 2008;105:467-473.
7. Bevolkerung in Hessen 2050. Statistisches Landesamt Hessen. 2005.
8. Hacke W, Brott T, Caplan L, Meier D, Fieschi C, von Kummer R, Donnan G, Heiss WD, Wahlgren NG, Spranger M, Boysen G, Marler JR. Thrombolysis in acute ischemic stroke: controlled trials and clinical experience. Neurology. 1999;53:S3-S14.
9. Wardlaw JM, Sandercock PA, Berge E. Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysis. Stroke. 2003; 34:1437-1442.
10. Tanne D, Gorman MJ, Bates VE, Kasner SE, Scott P, Verro P, Binder JR, Dayno JM, Schultz LR, Levine SR. Intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and older: the tPA stroke survey experience. Stroke. 2000;31:370-375.
11. Berrouschot J, Rother J, Glahn J, Kucinski T, Fiehler J, Thomalla G. Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (>or=80 years) stroke patients. Stroke. 2005;36:2421-2425.
12. Ringleb PA, Schwark C, Kohrmann M, Kulkens S, Juttler E, Hacke W, Schellinger PD. Thrombolytic therapy for acute ischaemic stroke in octogenarians: selection by magnetic resonance imaging improves safety but does not improve outcome. J Neurol Neurosurg Psychiatry. 2007;78: 690-693.
13. Actilyse Gebrauchsinformation. Boehringer Ingelheim. 2005.
14. Mant J, Hobbs FD, Fletcher K, Roalfe A, Fitzmaurice D, Lip GY, Murray E. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet. 2007;370:493-503.
15. Sandercock P, Lindley R, Wardlaw J, Dennis M, Lewis S, Venables G, Kobayashi A, Czlonkowska A, Berge E, Slot KB, Murray V, Peeters A, Hankey G, Matz K, Brainin M, Ricci S, Celani MG, Righetti E, Cantisani T, Gubitz G, Phillips S, Arauz A, Prasad K, Correia M, Lyrer P. The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke. Trials. 2008;9:37.
16. Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2003;2:43-53.