Functional and structural brain alterations in insomnia: Implications for pathophysiology

European Journal of Neuroscience

Volumn 29, Issue 9, 2009, Pages 1754-1760

  Riemann, D ^a   Kloepfer, C ^a   Berger, M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Brain function; Hyperarousal model; Insomnia

Indexed keywords

HYDROCORTISONE; INTERLEUKIN 6;

BRAIN METABOLISM; BRAIN SIZE; COGNITIVE DEFECT; ELECTROENCEPHALOGRAM; GENETIC SUSCEPTIBILITY; HIPPOCAMPUS; HORMONE SYNTHESIS; HUMAN; INSOMNIA; MEMORY CONSOLIDATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SLEEP WAKING CYCLE; WAKEFULNESS;

ANIMALS; BRAIN; COGNITION DISORDERS; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; MEMORY DISORDERS; MODELS, NEUROLOGICAL; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; WAKEFULNESS;

EID: 65549162011     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2009.06721.x     Document Type: Review

References (63)

1. American Academy of Sleep Medicine (AASM) (2005) International Classification of Sleep Disorders. 2nd Edn (ICSD-2). American Academy of Sleep Medicine, Westchester, IL.
2. Adam, K., Tomeny, M. Oswald, L. (1986) Physiological and psychological differences between good and poor sleepers. J. Psychiatr. Res., 20, 301 316. (Pubitemid 17200250)
3. Altena, E., Van der Werf, Y., Sanz-Arigita, E.J., Voorn, T.A., Rombouts, S., Kuijer, J. Van Someren, E. (2008) Prefrontal hypoactivation and recovery in insomnia. Sleep, 31, 1271 1276.
4. Ambrosius, U., Lietzenmaier, S., Wehrle, R., Wichniak, A., Kalus, S., Winkelmann, J., Bettecken, T., Holsboer, F., Yassourides, A. Friess, E. (2008) Heritability of sleep electroencephalogram. Biol. Psychiatry, 64, 344 348.
5. American Psychiatric Association (APA) (1994) Diagnostic and Statistical Manual of Mental Disorders (4th Edn). APA, Washington, DC.
6. Backhaus, J., Junghanns, K. Hohagen, F. (2004) Sleep disturbances are correlated with decreased morning awakening salivary cortisol. Psychoneuroendocrinology, 29, 1184 1191. (Pubitemid 38829180)
7. Backhaus, J., Junghanns, K., Born, J., Hohaus, K., Faasch, F. Hohagen, F. (2006) Impaired declarative memory consolidation during sleep in patients with primary insomnia: influence of sleep architecture and nocturnal cortisol release. Biol. Psychiatry, 60, 1324 1330.
8. Bastien, C., St-Jean, G., Morin, C., Turcotte, I. Carrier, J. (2008) Chronic psychophysiological insomnia: hyperarousal and/ or inhibition deficits? An ERPs investigation Sleep, 31, 887 898.
9. Beaulieu-Bonneau, S., LeBlanc, M., Merette, C., Dauvilliers, Y. Morin, C. (2007) Family history of insomnia in a population-based sample. Sleep, 30, 1739 1745. (Pubitemid 350234752)
10. Bonnet, M. Arand, D. (1995) 24-hour metabolic rate in insomniacs and matched normal sleepers. Sleep, 18, 581 588.
11. Brisbare-Roch, C., Dingemanse, J., Koberstein, R., Hoever, P., Aissaoui, H., Flores, S., Mueller, C., Nayler, O., van Gerven, J., de Haas, S.L., Hess, P., Qiu, C., Buchmann, S., Scherz, M., Weller, T., Fischli, W., Clozel, M. Jenck, F. (2007) Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat. Med., 13, 150 155. (Pubitemid 46245769)
12. Burgos, I., Richter, L., Klein, T., Fiebich, B., Feige, B., Lieb, K., Voderholzer, U. Riemann, D. (2006) Increased nocturnal Interleukin-6 excretion in patients with primary insomnia: a pilot study. Brain Behav. Immun., 20, 246 253.
13. Cano, G., Mochizuki, T. Saper, C.B. (2008) Neural circuitry of stress-induced insomnia in rats. J. Neurosci., 28, 10167 10184.
14. Dauvilliers, Y., Morin, C., Cervena, K., Carlander, B., Touchon, J., Besset, A. Billiard, M. (2005) Family studies in insomnia. J. Psychosom. Res., 58, 271 278. (Pubitemid 40603915)
15. Devoto, A., Manganelli, S., Lucidi, F., Lombardo, C., Russo, P.M. Violani, C. (2005) Quality of sleep and P300 amplitude in primary insomnia: a preliminary study. Sleep, 28, 859 863. (Pubitemid 40993717)
16. Edinger, J.D., Bonnet, M.H., Bootzin, R.R., Doghramji, K., Dorsey, C.M., Espie, C.A., Jamieson, A.O., McCall, W.V., Morin, C.M. Stepanski, E.J. (2004) Derivation of research diagnostic criteria for insomnia: report of an American academy of sleep medicine work group. Sleep, 27, 1567 1596. (Pubitemid 40041627)
17. Edinger, J., Means, M., Carney, C.E. Krystal, A.D. (2008) Psychomotor performance deficits and their relation to prior nights′ sleep among individuals with primary insomnia. Sleep, 31, 599 607.
18. Espie, C.A., Broomfield, N.M., MacMahon, K., Macphee, L.M. Taylor, L.M. (2006) The attention-intention-effort pathway in the development of psychophysiologic insomnia: a theoretical review. Sleep Med. Rev., 10, 215 245. (Pubitemid 44107728)
19. Fava, M., Mc Call, W.V., Krystal, A., Wessel, T., Rubens, R., Caron, J., Amato, D. Roth, T. (2006) Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol. Psychiatry, 59, 1052 1060. (Pubitemid 43849658)
20. Feige, B., Al-Shajlawi, A., Nissen, C., Voderholzer, U., Hornyak, M., Spiegelhalder, K., Kloepfer, C., Perlis, M.L. Riemann, D. (2008) Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients J. Sleep Res., 17, 180 190.
21. A receptor β3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population. Psychiatry Res., 104, 109 117. (Pubitemid 33050013)
22. Fulda, S. Schulz, H. (2001) Cognitive dysfunctions in sleep disorders. Sleep Med. Rev., 5, 423 445.
23. Gottesmann, C. (2002) GABA mechanisms and sleep. Neuroscience, 111, 231 239. (Pubitemid 34442609)
24. Irwin, M., Clark, C., Kennedy, B., Gillin, J.C. Ziegler, M. (2003) Nocturnal catecholamines and immune function in insomniacs, depressed pateints and control subjects. Brain Behav. Immun., 17, 365 372. (Pubitemid 36999843)
25. Lu, J., Sherman, D., Devor, M. Saper, C.B. (2006) A putative flip-flop switch for control of REM sleep. Nature, 441, 589 594. (Pubitemid 43927285)
26. Manber, R., Edinger, J., Gress, J.L., Pedro-Salcedo, S., Kuo, T.F. Kalista, T. (2008) Coginitive behavioural thewrapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia. Sleep, 31, 489 495.
27. Marsland, A.L., Gianaros, P.J., Abramowith, S.M., Manuck, S.B. Hariri, A.R. (2008) Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults. Biol. Psychiatry, 64, 484 490.
28. Meerlo, P., Mistlberger, R.E., Jacobs, B.L., Heller, H.C. McGinty, D. (in press) New neurons in the adult brain: the role of sleep and consequences of sleep loss. Sleep Med. Rev., in press.
29. Monroe, L.J. (1967) Psychological and physiological differences between good and poor sleepers. J. Abnorm. Psychol., 72, 255 264.
30. National Institutes of health state of the science conference statement (NIH) (2005) Manifestations and management of chronic insomnia in adults, June 13-15, 2005. Sleep, 28, 1049 1057.
31. Nissen, C., Kloepfer, C., Nofzinger, E.A., Feige, B., Voderholzer, U. Riemann, D. (2006) Impaired sleep-related memory consolidation in primary insomnia. Sleep, 29, 1068 1073.
32. Nofzinger, E.A., Buysse, D.J., Germain, A., Price, J.C., Miewald, J.M. Kupfer, D.J. (2004) Functional neuroimaging evidence for hyperarousal in insomnia. Am. J. Psychiatry, 161, 2126 2129. (Pubitemid 39441418)
33. Nofzinger, E.A., Nissen, C., Germain, A., Moul, D., Hall, M., Price, J., Miewald, J. Buysse, D. (2006) Regional cerebral metabolic correlates of WASO during NREM sleep in insomnia. J. Clin. Sleep Med., 2, 316 322. (Pubitemid 44299556)
34. Ohayon, M. (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med. Rev., 6, 97 111. (Pubitemid 35231066)
35. Orff, H., Drummond, S.P., Nowakowski, S. Perlis, M.L.P. (2007) Discrepancy between subjective symptomatology and objective neuropsychological performance in insomnia. Sleep, 30, 1205 1211. (Pubitemid 47378963)
36. Perlis, M.L., Giles, D.E., Mendelson, W.B., Bootzin, R.R. Wyatt, J.K. (1997) Psychophysiological insomnia: the behavioural model and a neurocognitive perspective. J. Sleep Res., 6, 179 188. (Pubitemid 27414458)
37. Perlis, M.L., Merica, H., Smith, M.T. Giles, D.E. (2001a) Beta EEG activity and insomnia. Sleep Med. Rev., 5, 365 376. (Pubitemid 33089569)
38. Perlis, M.L., Smith, M.T., Orff, H., Andrews, P. Giles, D.E. (2001b) Beta/gamma activity in patients with insomnia and in good sleeper controls. Sleep, 24, 110 117. (Pubitemid 32096740)
39. Perlis, M.L., Pigeon, W.R. Drummond, S.P. (2006) The neurobiology of insomnia. In Gilman, S. (ed Neurobiology of Disease. Elsevier, Burlington, MA, Chapter 68, pp. 735 744.
40. Pigeon, W.R. Perlis, M.L. (2006) Sleep homeostasis in primary insomnia. Sleep Med. Rev., 10, 247 254. (Pubitemid 44107725)
41. Pigeon, W.R. Perlis, M.L. (2007) Insomnia and depression: birds of a feather? Int. J. Sleep Disord., 1, 82 91.
42. Rechtschaffen, A. Kales, A.A. (1968) Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. US Government Printing Office, Public Health Service, Washington, DC.
43. Redwin, L., Hauger, R.L., Gillin, J.C. Irwin, M. (2000) Effects of sleep and sleep deprivation on interleukin-6, growth horomone, cortisol and melatonin levels in humans. J. Clin. Endocrinol. Metab., 85, 3597 3603.
44. Rétey, J.V., Adam, M., Honegger, E., Khatami, R., Luhmann, U.F., Jung, H.H., Berger, W. Landolt, H.P. (2005) A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc. Natl Acad. Sci. USA, 102, 15676 15681. (Pubitemid 41528115)
45. Riedel, B.W. Lichstein, K.L. (2000) Insomnia and daytime functioning. Sleep Med. Rev., 4, 277 298. (Pubitemid 30416010)
46. Riemann, D. Voderholzer, U. (2003) Primary insomnia: a risk factor to develop depression? J. Affect. Disord., 76, 255 259. (Pubitemid 37013378)
47. Riemann, D., Berger, M. Voderholzer, U. (2001) Sleep and depression - results from psychobiological studies: an overview. Biol. Psychol., 57, 67 103. (Pubitemid 32651895)
48. Riemann, D., Klein, T., Rodenbeck, A., Feige, B., Horny, A., Hummel, R., Weske, G., Al-Shajlawi, A. Voderholzer, U. (2002) Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiatry Res., 113, 17 27. (Pubitemid 35447721)
49. Riemann, D., Voderholzer, U., Spiegelhalder, K., Hornyak, M., Buysse, D.J., Nissen, C., Hennig, J., Perlis, M.L., van Elst, L.T. Feige, B. (2007) Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep, 30, 955 958. (Pubitemid 47221894)
50. Rodenbeck, A., Hüther, G., Rüther, E. Hajak, G. (2002) Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia. Neurosci. Lett., 324, 159 163. (Pubitemid 34460695)
51. Saper, C.B., Scammell, T.E. Lu, J. (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature, 437, 1257 1263. (Pubitemid 41568665)
52. Smith, M.T. Perlis, M.L. (2005) NREM sleep cerebral blood flow before and after behavior therapy for chronic insomnia: preliminary single photon emission computed tomography (SPECT) data. Sleep Med., 6, 93 94.
53. Smith, M.T., Perlis, M.L., Chengazi, V.U., Pennington, J., Soeffing, J., Ryan, J.M. Giles, D.E. (2002) Neuroimaging of NREM sleep in primary insomnia: a preliminary, Tc-99-HMPAO single photon emission computed tomography study. Sleep, 25, 325 335. (Pubitemid 34496413)
54. Spiegel, K., Leproult, R. van Cauter, E. (1999) Impact of sleep debt on metabolic and endocrine function. Lancet, 354, 1435 1439. (Pubitemid 29494756)
55. Stickgold, R. (2005) Sleep- dependent memory consolidation. Nature, 437, 1272 1278.
56. Terzano, M.G., Parrino, L., Spaggiari, M.C., Palomba, V., Rossi, M. Smerieri, A. (2003) CAP variables ands arousals as sleep electroencephalographic markers for primary insomnia. Clin. Neurophysiol., 114, 1715 1723. (Pubitemid 37025805)
57. Varkevisser, M., van Dongen, H.P. Kerkhof, G.A. (2005) Physioloogical indexes in chronic insomnia during a constant routine: evidence for general hyperarousal? Sleep, 28, 1588 1596. (Pubitemid 41747087)
58. Vgontzas, A.N. Chrousos, G.P. (2002) Sleep, the hypothalamic-pituitary- adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders. Endocrinol. Metab. Clin. North Am., 31, 15 36. (Pubitemid 34578612)
59. Vgontzas, A.N., Papanicolau, D.A., Bixler, E.O., Lotzikas, A., Zachmann, K. Kales, A. (1999) Circadian interleukin-6 secretion and quantity and depth of sleep. J. Clin. Endocrinol. Metab., 84, 2603 2607. (Pubitemid 30641979)
60. Vgontzas, A.N., Bixler, E.O., Lin, H.M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A. Chrousos, G.P. (2001) Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J. Clin. Endocrinol. Metab., 86, 3787 3794. (Pubitemid 32755977)
61. Watson, N.F., Goldberg, J., Arguelles, L. Buchwald, D. (2006) Genetic and environmental influences on insomnia, daytime sleepiness, and obesity in twins. Sleep, 29, 645 649. (Pubitemid 43752928)
62. Winkelmann, J.W., Buxton, O.M., Jensen, E., Benson, K.L., O′Connor, S.P., Wang, W. Renshaw, P.F. (2008) Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep, 31, 1499 1506.
63. Yang, C.M. Lo, H.S. (2007) ERP evidence of enhanced excitatory and reduced inhibitory processes of auditory stimuli during sleep in patients with primary insomnia. Sleep, 30, 585 592. (Pubitemid 46941563)