Intensive insulin therapy in critical care settings

Current Clinical Pharmacology

Volumn 4, Issue 1, 2009, Pages 71-77

  Eastman, Darla Klug ^a,b   Bottenberg, Michelle M ^a,b   Hegge, Karly A ^b,c   Ourth, Heather ^a   Kabadi, Udaya ^a,d  

^a Veterans Affairs Central Iowa Healthcare System   (United States)

^b DRAKE UNIVERSITY   (United States)

^c Penn Avenue Internal Medicine ^*  (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Critical illness; Hyperglycemia; Insulin

Indexed keywords

GLUCOSE; INSULIN; ANTIDIABETIC AGENT;

BLOODSTREAM INFECTION; CLINICAL TRIAL; COMORBIDITY; CONTINUOUS INFUSION; COST CONTROL; COST EFFECTIVENESS ANALYSIS; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIABETES MELLITUS; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEALTH CARE COST; HEALTH CARE QUALITY; HEALTH EDUCATION; HIGH RISK PATIENT; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN TREATMENT; INTENSIVE CARE; LENGTH OF STAY; MORBIDITY; MORTALITY; PATIENT MONITORING; PATIENT SAFETY; PRACTICE GUIDELINE; PREVALENCE; PRIORITY JOURNAL; QUALITY CONTROL; REFERENCE VALUE; REVIEW; RISK BENEFIT ANALYSIS; RISK REDUCTION; SEPTIC SHOCK; INTENSIVE CARE UNIT; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; TREATMENT OUTCOME;

BLOOD GLUCOSE; CRITICAL ILLNESS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INSULIN; INTENSIVE CARE UNITS; TREATMENT OUTCOME;

EID: 65549150394     PISSN: 15748847     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488409787236100     Document Type: Review

References (37)

1. Malmberg K, Ryden L, Wedel H, Birkeland K, Bootsma A, Dickstein K, et al. DIGAMI Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI-2): effects on mortality and morbidity. Eur Heart J 2005; 26: 650-1.
2. Umpierrez G, Isaacs S, Bazargan N, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of inhospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 2002; 87: 978-82.
3. Mehta SR, Yusuf S, Diaz R, et al. CREATE-ECLA Trial Group Investigators. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA 2005; 293: 437-46.
4. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 2000; 355: 773-8.
5. Muhlestein JB, Anderson JL, Horne BD, et al. Effect of fasting glucose levels on mortality rate in patients with and without diabetes mellitus and coronary artery disease undergoing percutaneous coronary intervention. Am Heart J 2003; 146: 351-8.
6. Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma 2003; 55: 33-8.
7. Laird AM, Miller PR, Kilgo PD, Meredith JW, Chang MC. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004; 56: 1058-62.
8. Bochicchio GV, Sung J, Joshi M, et al. Persistent hyperglycemia is predictive of outcome of critically ill trauma patients. J Trauma 2005; 1277-8.
9. Sung J, Bochicchio GV, Joshi M, Bochicchio K, Tracy K, Scalea TM. Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005; 59-80-3.
10. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogenous population of critically ill patients. Mayo Clin Proc 2003; 78: 1471-8.
11. Clement S, Braithwaite SS, Magee MF, et al. American Diabetes Association Diabetes in Hospitals Writing Committee. Management of diabetes and hyperglycemia in hospitals. Diabetes Care 2004; 27: 553-91.
12. Montori VM, Bistrian BR, McMahon MM. Hyperglycemia in acutely ill patients. JAMA 2002; 288: 2167-9.
13. American Diabetes Association. Standards of medical care in diabetes - 2008. Diabetes Care 2008; 31: S12-54.
14. Garber AJ, Moghissi ES, Bransome ED Jr, et al. American College of Endocrinology Task Force on Inpatient Diabetes Metabolic-Control. American College of Endocrinology position statement on inpatient diabetes and metabolic control. Endocr Pract 2004; 10: 77-82.
15. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36: 296-327.
16. Queale WS, Alexander J, Brancati FL. Glycemic control and sliding scale insulin use in medical inpatients with diabetes mellitus. Arch Intern Med 1997; 157: 545-52.
17. Schnipper JL, Barsky EE, Shaykevich S, Fitzmaurice G, Pendergrass ML. Inpatient management of diabetes and hyperglycemia among general medicine patients at a large teaching hospital. J Hosp Med 2006; 1: 145-50.
18. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345: 1359-67.
19. Van den Berghe G, Wouters PJ, Kesteloot K, Hilleman DE. Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients. Crit Care Med 2006; 34: 612-6.
20. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354: 449-61.
21. Van den Berghe G, Wilmer A, Milants I, et al. Intensive insulin therapy in mixed medical/surgical ICU: benefit versus harm. Diabetes 2006; 44: 3151-9.
22. Grey NJ, Perdrizet GA. Reduction of nosocomial infections in the surgical intensive-care unit by strict glycemic control. Endocr Pract 2004; 10(suppl2): 46-52.
23. Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill patients. Mayo Clin Proc 2004; 79: 992-1000.
24. National Institutes of Health. Glucontrol study: comparing the effects of two glucose control regimens by insulin in intensive care unit patients. Available at: http://www.clinicaltrials.gov/ct/show/ NCT00107601. Accessed June 24, 2008.
25. Preiser JC. Data presented at 19th European Symposium on Intensive Care Medicine, Barcelona, Spain, September 24-27, 2000.
26. Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358: 125-39.
27. Pittas AG, Siegel RD, Lau J. Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized, controlled trials. Arch Intern Med 2004; 164: 2005-11.
28. National Institutes of Health. Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR STUDY). Available at: http://www.clinicaltrials.gov/ct2/show/ NCT00220987?term=nice+sugar&rank=1. Accessed June 24, 2008.
29. AACE/ADA Task Force on Inpatient Diabetes. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient diabetes and glycemic control: a call to action. Diabetes Care 2006; 29: 1955-62.
30. Boord JB, Graber AL, Christman JW, Powers AC. Practical management of diabetes in critically ill patients. Am J Respir Crit Care Med 2001; 164: 1763-7.
31. Mackenzie I, Ingle S, Zaidi S, Buczaski S. Hypoglycemia? So what? Intensive Care Med 2006; 32: 620-1.
32. Vriesendorp TM, DeVrioes JH, van Santen S, et al. Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med 2006; 34: 2714-8.
33. Trence DL, Kelly JL, Hirsch IB. The rationale and management of hyperglycemia for in-patients with cardiovascular disease: time for change. J Clin Endocrinol Metab 2003; 88: 2430-7.
34. Krinsley J, Jones R. Cost analysis of intensive glycemic control in critically ill adult patients. CHEST 2006; 129: 644-50.
35. Levetan CS, Salas JR, Wilets IF, Zumoff B. Impact of endocrine and diabetes team consultation on hospital length of stay for patients with diabetes. Am J Med 1995; 99: 22-8.
36. Protecting 5 Million Lives from Harm. The Institute for Healthcare Improvement. Available at: http://ihi.org/IHI/Programs/Campaign. Accessed June 24, 2008.
37. Inpatient Diabetes Certificatioin. Available at: http://www.jointcommission.org/certificationprograms/inpatient+diabetes. Accessed June 23, 2008.