Is antimicrobial underexposure due to glomerular hyperfiltration a possible cause of increased mortality rate from bacterial infections in critically ill patients?

Anaesthesia and Intensive Care

Volumn 37, Issue 2, 2009, Pages 323-324

  Pea, F ^a   Furlanut, M ^a   Viale, P ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; LEVOFLOXACIN; PIPERACILLIN; POLYPEPTIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

BACTERIAL INFECTION; CRITICAL ILLNESS; DIASTOLIC BLOOD PRESSURE; DRUG TREATMENT FAILURE; DRUG URINE LEVEL; GLOMERULUS FILTRATION RATE; HUMAN; INTENSIVE CARE; LETTER; MORTALITY; RISK FACTOR; KIDNEY; METABOLISM; NOTE;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CRITICAL ILLNESS; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY;

EID: 65549149097     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (6)

1. Fuster-Lluch O, Geronimo-Pardo M, Peyro-Garcia R, Lizan-Garcia M. Glomerular hyperfiltration and albuminuria in critically ill patients. Anaesth Intensive Care 2008; 36:674-680.
2. Pea F, Viale P, Furlanut M. Antimicrobial therapy in critically ill patients: a review of pathophysiological conditions responsible for altered disposition and pharmacokinetic variability. Clin Pharmacokinet 2005; 44:1009-1034.
3. Pea F, Pavan F, Furlanut M. Clinical relevance of pharmacokinetics and pharmacodynamics in cardiac critical care patients. Clin Pharmacokinet 2008; 47:449-462.
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5. Cox HJ, Bhandari S, Rigby AS, Kilpatrick ES. Mortality at low and high estimated glomerular filtration rate values: a 'U' shaped curve. Nephron Clin Pract 2008; 110:c67-72.
6. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008; 34:17-60.