Risk factors for and influence of bloodstream infections on mortality: A 1-year prospective study in a Greek intensive-care unit

Epidemiology and Infection

Volumn 137, Issue 5, 2009, Pages 727-735

  Pratikaki, M ^a,b   Platsouka, E ^b   Sotiropoulou, C ^a   Vassilakopoulos, T ^a   Paniara, O ^b   Roussos, C ^a   Routsi, C ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Bloodstream infection; ICU; Mortality; Risk factors

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; SERUM ALBUMIN; TOBRAMYCIN;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ALBUMIN BLOOD LEVEL; ANAMNESIS; ANTIBIOTIC RESISTANCE; APACHE; ARTICLE; BLOODSTREAM INFECTION; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; GRAM NEGATIVE INFECTION; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROSPECTIVE STUDY; RISK FACTOR; GREECE; MICROBIOLOGY; MIDDLE AGED; MULTIDRUG RESISTANCE; SEPSIS;

ADULT; AGED; APACHE; DIABETES COMPLICATIONS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; GREECE; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK FACTORS; SEPSIS;

EID: 65549149052     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268808001271     Document Type: Article

References (40)

1. Wenzel RP, Edmond MB. The impact of hospital-acquired bloodstream infections. Emerging Infectious Diseases 2001; 7: 174-177.
2. Pittet D, et al. Microbiological factors influencing the outcome of nosocomial bloodstream infections: A 6-year validated, population-based model. Clinical Infectious Diseases 1997; 24 1068-1078.
3. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients: Excess length of stay, extra costs, and attributable mortality. Journal of the American Medical Association 1994; 271: 1598-1601.
4. Rello J, et al. Nosocomial bacteremia in a medical-surgical intensive care unit: Epidemiologic characteristics and factors influencing mortality in 111 episodes. Intensive Care Medicine 1994; 20: 94-98.
5. Valles J, Leon C, Alvarez-Lerma F. Nosocomial bacteremia in critically ill patients: A multicenter study evaluating epidemiology and prognosis. Clinical Infectious Diseases 1997; 24: 387-395.
6. Brun-Buisson C, Doyon F, Carlet J. Bacteremia and severe sepsis in adults: A multicenter prospective survey in ICUs and wards of 24 hospitals. American Journal of Respiratory and Critical Care Medicine 1996; 154: 617-624.
7. Harbarth S, et al. Epidemiology and prognostic determinants of bloodstream infections in surgical intensive care. Archives of Surgery 2002; 137: 1353-1359.
8. Jones RN. The emergent needs for basic research, education, and surveillance of antimicrobial resistance. Problems facing the report from the American Society for Microbiology Task Force on Antibiotic Resistance. Diagnostic Microbiology and Infectious Disease 1996; 25: 153-161.
9. WHONET Greece. Greek system for the surveillance of antimicrobial resistance (http://www.mednet.gr/whonet). Accessed 19 February 2008.
10. Routsi C, et al. Application of the sequential organ failure assessment (SOFA) score to bacteremic ICU patients. Infection 2007; 35: 240-244.
11. Knauss WA, et al. APACHE II: A severity of disease classification system. Critical Care Medicine 1985; 13: 818-829.
12. Kajdacsy-Balla AC, et al. Use of sequential organ failure assessment score as a severity score. Intensive Care Medicine 2005; 31: 243-249.
13. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions of sepsis, organ failure and guidelines of innovative therapies in sepsis. Critical Care Medicine 1992; 20: 864-874.
14. Garner JS, et al. CDC definitions for nosocomial infections, 1988. American Journal of Infection Control 1988; 16: 128-140.
15. Correa L, Pittet D. Problems and solutions in hospital-acquired bacteraemia. Journal of Hospital Infection 2000; 46: 89-95.
16. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. Approved standard, 7th edn. NCCLS document M2-A7. Wayne, PA: National Committee for Clinical Laboratory Standards, 2000.
17. Pittet D, Wenzel RP. Nosocomial blood stream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Archives of Internal Medicine 1995; 155: 1177-1184.
18. Laupland KB, et al. Intensive care unit acquired bloodstream infections in a regional critically ill population. Journal of Hospital Infection 2004; 58: 137-145.
19. Pittet D, et al. Nonantimicrobial measures to prevent infections in critical care. In: Clinical Critical Care Medicine. Philadelphia: Mosby Elsevier, 2006, pp. 71-86.
20. Borg MA, et al. Bed occupancy and overcrowding as determinant factors in the incidence of MRSA infections with general ward settings. Journal of Hospital Infection 2003; 54: 316-318.
21. Tsai CL, et al. Impact of diabetes on mortality among patients with community acquired bacteremia. Journal of Infection 2007; 55: 27-33.
22. Sreeramoju PV, et al. Predictive factors for the development of central line-associated bloodstream infection due to gram negative bacteria in intensive care unit patients after surgery. Infecion Control and Hospital Epidemiology 2008; 29: 51-56.
23. Rello J, et al. Evaluation of outcome of intravenous catheter-related infections in critically ill patients. American Journal of Respiratory and Critical Care Medicine 2000; 162: 1027-1030.
24. Blot S, Vandewoude K, Colardyn F. Nosocomial bacteremia involving Acinetobacter baumannii in critically ill patients: A matched cohort study. Intensive Care Medicine 2003; 29: 471-475.
25. Fein AM, et al. The risk factors, incidence, and prognosis of the adult respiratory distress syndrome following septicemia. Chest 1983; 83: 40-42.
26. Kaplan RL, Sahn SA, Petty TL. Incidence and outcome of the respiratory distress syndrome in Gram-negative sepsis. Archives of Internal Medicine 1979; 139: 867-869.
27. Bueno-Cavanilas A, et al. Influence of nosocomial infection on mortality rate in an intensive care unit. Critical Care Medicine 1994; 22: 55-60.
28. National Nosocomial Infections Surveillance (NNIS) System report. Data summary from January 1990-May 1999, issued June 1999. American Journal of Infection Control 1999; 27: 520-532.
29. Waterer GW, Wunderink RG. Increasing threat of Gram-negative bacteria. Critical Care Medicine 2001; 29 (Suppl.): N75-N81.
30. Gaynes R, Edwards JR, and the National Nosocomial Infections Surveillance System. Overview of nosocomial infections caused by gram-negative bacilli. Clinical Infectious Diseases 2005; 41 848-854.
31. Kang CI, et al. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: Risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicroial Agents and Chemotherapy 2005; 49: 760-766.
32. Kohlenberg A, et al. Time trends for Gram-negative and multidrug resistant Gram positive bacteria associated with nosocomial infections in German intensive care units between 2000 and 2005. Clinical Microbiology and Infection 2008; 14: 93-96.
33. Kraniotaki E, et al. Molecular investigation of an outbreak of multidrug-resistant Acinetobacter baumannii, with characterization of class 1 integrons. International Journal of Antimicrobial Agents 2006; 28: 193-199.
34. Falagas ME, et al. Trends in antimicrobial resistance of Acinetobacter baumannii clinical isolates from hospitalized patients in Greece and treatment implications. Clinical Microbiology and Infection 2007; 13: 816-819.
35. Wu CJ, et al. Predominance of Gram-negative bacilli and increasing antimicrobial resistance in nosocomial bloodstream infections at a university hospital in southern Taiwan, 1996-2003. Journal of Microbiology, Immunology and Infection 2006; 39: 135-143.
36. Jerassy Z, et al. Prospective hospital-wide studies of 505 patients with nosocomial bacteremia in 1997 and 2002. Journal of Hospital Infection 2006; 62: 230-236.
37. Flournoy DJ, et al. Increasing antimicrobial resistance in Gram-negative bacilli isolated from patients in intensive care units. American Journal of Infection Control 2000; 28: 244-250.
38. Jones RN. Resistance patterns among nosocomial pathogens: Trends over the past few years. Chest 2001; 119 (Suppl. 2): 397S-404S.
39. Raymond DP, et al. Impact of antibiotic-resistant Gram-negative bacilli infections on outcome in hospitalized patients. Critical Care Medicine 2003; 31: 1035-1041.
40. Harbarth S, et al. Impact and pattern of Gram-negative bacteremia during 6 y at a large university hospital. Scandinavian Journal of Infectious Diseases 1999; 31: 163-168.