Immunolocalization and serum antibody responses to Brugia malayi pepsin inhibitor homolog (Bm-33)

Microbiology and Immunology

Volumn 53, Issue 3, 2009, Pages 173-183

  Krushna, Nagampalli S A ^a   Shiny, Chandanpurath ^a   Dharanya, Srinivasan ^a   Sindhu, Arivazhagan ^a   Aishwarya, Sridharan ^a   Narayanan, Rangarajan B ^a  

^a ANNA UNIVERSITY   (India)

Author keywords

Antibody; Brugia malayi; ELISA; Immunolocalization; Isotype

Indexed keywords

HISTIDINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G4; BM 33 PROTEIN, BRUGIA MALAYI; BM-33 PROTEIN, BRUGIA MALAYI; COMPLEMENTARY DNA; HELMINTH ANTIBODY; HELMINTH PROTEIN; HYBRID PROTEIN; PARASITE ANTIGEN;

ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; BRUGIA MALAYI; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOCALIZATION; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; SETARIA DIGITATA; WESTERN BLOTTING; ADOLESCENT; ADULT; AFFINITY CHROMATOGRAPHY; ANIMAL; BLOOD; CHEMISTRY; DERMIS; FEMALE; FILARIOIDEA; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; MIDDLE AGED; MOLECULAR CLONING; MOLECULAR GENETICS; MOLECULAR WEIGHT; SEQUENCE ALIGNMENT;

BOS; BRUGIA MALAYI; SETARIA DIGITATA;

ADOLESCENT; ADULT; ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; BASE SEQUENCE; BRUGIA MALAYI; CHROMATOGRAPHY, AFFINITY; CLONING, MOLECULAR; DERMIS; DNA, COMPLEMENTARY; FEMALE; FILARIOIDEA; HELMINTH PROTEINS; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; YOUNG ADULT;

EID: 65549147726     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2009.00114.x     Document Type: Article

References (33)

1. Rao K.V.N., Eswaran D., Ravi V., Gnanasekhar M., Narayanan R.B., Kaliraj P. et al. (2000) The Wuchereria bancrofti orthologue of Brugia malayi SXP1 and the diagnosis of bancroftian filariasis. Mol Biochem Parasitol 107: 71-80.
2. Sabarinathan R., Pankaj Kumar M., Reddy M.V.R., Harinath B.C., Nutman T.B., Kaliraj P. et al. (2004) The larval specific lymphatic filarial ALT-2 induction of protection using protein or DNA vaccination. Microbiol Immunol 48: 945-55.
3. Dissanayake S., Xu M., Nkenfou C., Piessens W.F. (1993) Molecular cloning and serological characterization of Brugia malayi pepsin inhibitor homolog. Mol Biochem Parasitol 62: 143-6.
4. Gregory W.F., Atmadia A.K., Allen J.E., Maizels R.M. (2000) The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infect Immun 68: 4174-9.
5. Lucius R., Kern A., Seeber F., Pogonka T., Willenbucher J., Taylor H.R. et al. (1992) Specific and sensitive IgG4 immunodiagnosis of onchocerciasis with a recombinant 33 kDa Onchocerca volvulus protein (Ov33). Trop Med Parasitol 43: 139-45.
6. Tawill S.A., Kipp W., Lucius R., Gallin M., Erttman K.D., Buttner D.W. (1995) Immunodiagnostic studies on Onchocerca volvulus and Mansonella perstans infections using a recombinant 33 kDa O. volvulus protein (Ov33). Trans R S Trop Med Hyg 89: 51-4.
7. Hong X.Q., Mejia J.S., Kumar S., Perler F.B., Carlow C.K.S. (1996) Cloning and expression of Dit33 from Dirofilaria immitis: A specific and early marker for heart worm infection. Parasitology 3: 331-8.
8. Willenbucher J., Hofle W., Lucius R. (1993) The filarial antigens Av33/Ov33 show striking similarities to the major pepsin inhibitor from Ascaris suum. Mol Biochem Parasitol 57: 349-52.
9. Bal M., Das M.K. (1999) Antibody response to a filarial antigen fraction in individuals exposed to Wuchereria bancrofti infection in India. Act Trop 72: 259-74.
10. Sambrook J., Fritsch E.F., Maniatis T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
11. Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-5.
12. Chanteau S., Moulia-Pelat J.P., Glaziou P., Nguyen N.L., Luquiaud P., Plichart C. et al. (1994) Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti Filariasis. J Infect Dis 170: 247-50.
13. Gowri Shankar J., Bhandari P. (1997) An Escherichia coli host strain useful for efficient over production of cloned gene products with NaCl as the inducer. J Bacteriol 179: 4403-6.
14. Studier F.W., Moffat B.A. (1986) Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J Mol Biol 189: 113-30.
15. Mejia J.S., Nkenfou C., Southworth M.W., Ferler F.B., Carlow C.K.S. (1994) Expression of an Onchocerca volvulus Ov33 homolog in Dirifilaria immitis. Potential for immunodiagnosis of heart worm. Parasite Immunol 16: 297-303.
16. Pogonka T., Bratting N., Nde P.N., Adam R., Seeber F., Zipfel P.F. et al. (1997) Localization of T and B Cell stimulating domains of the immunodominant 33 kDa protein of Onchocerca volvulus. Clin Immunol Immunopathol 85: 55-66.
17. Maizels R.M., Blaxter M.L., Scott A.L. (2001) Immunological genomics of Brugia malayi: filarial genes involved in immune evasion and protective immunity. Parasite Immunol 23: 327-44.
18. Mustafa A.S., Shaban F.A. (2006) Propred analysis and experimental evaluation of promiscuous T-cell epitopes of three major secreted antigens of Mycobacterium tuberculosis. Tuberculosis 86: 115-24.
19. Hussain R., Grogl M., Ottesen E. (1987) Differential subclass recognition of parasite antigen correlates with different clinical manifestations of infections. J Immunol 139: 2794-8.
20. Shakib F., Stanworth D.R. (1980) Human IgG subclasses in health and disease. Part II. La Ricer Clin Lab 10: 463-5.
21. Mc Greevy P.B., Ratiwayanto S., Tuti S., Mc Greevy M.M., Dennis D.T. (1980) Brugia malayi: relationship between anti sheath antibodies and amicrofilaremia in natives living in an endemic area of South Kalimantan. Borneo Ann J Trop Med Hyg 29: 508-13.
22. Ravindran B., Sathapathy A.K., Das M.K., Pattnaik N.M., Subramanyam V.R. (1990) Antibodies to microfilarial sheath in Bancroftian Filariasis- prevalence and characterization. Ann Trop Med Parasitol 84: 607-13.
23. Day K.P. GregoryW.F.,Maizels R.M. (1991) Age specific acquisition of immunity to infective larvae in bancroftian filariasis endemic area of Papua New Guinea. Parasite Immunol 13: 277-90.
24. Mohanty M.C., Sathapathy A.K., Sahoo P.K., Ravindran B. (2001) Human bancroftian filariasis- a role for antibodies to parasite carbohydrates. Clin Exp Immunol 154: 54-61.
25. Siber G.R., Schur P.H., Aisenberg A.C., Weitzman S.A., Schiffman G. (1980) Correlation between serum IgG2 concentrations and the antibody response to bacterial polysaccharide antigens. N Engl J Med 303: 178-82.
26. Yazdanbaksh M., Paxton W.A., Brandenburg A., VanRee R., Lens M., Partano F. et al. (1995) Differential antibody isotype reactivity to specific antigens in human lymphatic filariasis: gp15/400 preferentially induces immunoglobulin E (IgE), IgG4, and IgG2. Infect Immun 63: 3772-9.
27. Kwan-Lim G.E., Forsyth K.P., Maizels R.M. (1990) Filarial-specific IgG4 response correlates with active Wuchereria bancrofti infection. J Immunol 145: 4298.
28. Day K.P. (1991) The endemic normal in filariasis: a static concept. Parasitol Today 7: 341.
29. Weil G.J., Ramzy R.M.R., Chandrashekar R., Gad A.M., Lowries R.C Jr., Faris R. (1986) Parasite antigenemia without microfilaremia in bancroftian filariasis. Am J Trop Med Hyg 55: 333-7.
30. Garruad O., Nkenfou C., Bradley J.E., Nutman T.B. (1995) Identification of recombinant filarial proteins capable of inducing polyclonal and antigen -specific IgE and IgG4 antibodies. J Immunol 8: 1316-25.
31. Hussain R., Pointdexter R.W., Ottesen E.A. (1992) Control of allergic reactivity in human Filariasis-predominant localization of blocking antibody to the IgG4 subclass. J Immunol 148: 2731-7.
32. Sasisekhar B., Suba N., Sindhuja S., Sofi G.M.A., Naranayan R.B. (2005) Setaria digitata: Identification and characterization of a hypodermally expressed SXP/RAL-2 protein. Exp Parasitol 111: 121-5.
33. Sasisekhar B., Aparna M., Augustin D.J., Kaliraj P., Kar S.K., Nutman T.B. et al. (2005) Diminished monocyte function in microfilaremic patients with lymphatic filariasis and its relationship to altered lymphoproliferative responses. Infect Immun 73: 3385-93.