Protein content in aqueous humor from patients with pseudoexfoliation (PEX) investigated by capillary LC MALDI-TOF/TOF MS

Proteomics - Clinical Applications

Volumn 3, Issue 3, 2009, Pages 299-306

  Hardenborg, Emilia ^a   Botling Taube, Amelie ^a   Hanrieder, Jörg ^a   Andersson, Marit ^a   Alm, Albert ^a   Bergquist, Jonas ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Aqueous humor; Capillary liquid chromatography; Human body fluids; MALDI TOF MS; MS; Pseudoexfoliation syndrome

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; ANTITHROMBIN III; APOLIPOPROTEIN A1; BETA CRYSTALLIN; BETA2 GLYCOPROTEIN 1; CARRIER PROTEIN; CLUSTERIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4A; CRYSTALLIN; CYSTATIN C; FETUIN A; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; HEMOPEXIN; IMMUNOGLOBULIN HEAVY CHAIN; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; KININOGEN; OROSOMUCOID; OSTEOPONTIN; PANCREATIC RIBONUCLEASE; PREALBUMIN; PROTHROMBIN; TRANSFERRIN; VITAMIN D BINDING PROTEIN;

ADULT; AGED; AMINO ACID SEQUENCE; ANALYTIC METHOD; AQUEOUS HUMOR; ARTICLE; CAPILLARY CHROMATOGRAPHY; CATARACT; CLINICAL ARTICLE; COMPLEMENT FACTOR; CONTROLLED STUDY; FEMALE; FUNCTIONAL PROTEOMICS; GEL ELECTROPHORESIS; HUMAN; IMMUNE RESPONSE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN FUNCTION; PSEUDOEXFOLIATION; QUANTITATIVE ANALYSIS;

EID: 65549144415     PISSN: 18628346     EISSN: None     Source Type: Journal    
DOI: 10.1002/prca.200780077     Document Type: Article

References (37)

1. Lindberg, J. G., Kliniska undersökningar över depigmentering av pupillarranden och genomlysbarhet av iris vid fall av ålderstarr samt i normala ögon hos gamla personer [Clinical studies of depigmentation of the pupillary margin and transillumination of the iris in cases of senile cataract and also in normal eyes in the aged]. Thesis, University of Helsinki, Helsinki, Finland, 1917.
2. Ritch, R., Schlotzer-Schrehardt, U., Exfoliation syndrome. Surv. Ophthalmol. 2001, 45, 265-315.
3. Thorleifsson, G., Magnusson, K. P., Sulem, P., Walters, G. B. et al., Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science 2007, 317, 1397-1400.
4. Ringvold, A., Epidemiology of the pseudo-exfoliation syndrome - A review. Acta Ophthalmol. Scand. 1999, 77, 371-375.
5. Quigley, H. A., Broman, A. T., The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol. 2006, 90, 262-267.
6. Naumann, G. O. H., Schlotzer-Schrehardt, U., Kuchle, M., Pseudoexfoliation syndrome for the comprehensive ophthalmologist - Intraocular and systemic manifestations. Ophthalmology 1998, 105, 951-968.
7. Lumme, P., Laatikainen, L., Exfoliation syndrome and cataract-extraction. Am. J. Ophthalmol. 1993, 116, 51-55.
8. Ovodenko, B., Rostagno, A., Neubert, T. A., Shetty, V. et al., Proteomic analysis of exfoliation deposits. Invest. Ophthalmol. Vis. Sci. 2007, 48, 1447-1457.
9. Brubaker, R. F., Flow of aqueous-humor in humans - The Friedenwald lecture. Invest. Ophthalmol. Vis. Sci. 1991, 32, 3145-3166.
10. True-Gabelt, B., Kaufman, P. L., in: Kaufman, P. L., Alm, A. (Eds.), Adler's Physiology of the Eye, Mosby, St. Louis 2002, pp. 237-271.
11. Zirm, M., Proteins in aqueous humor. Adv. Ophthalmol. 1980, 40, 100-172.
12. Määttä, M., Tervahartiala, T., Harju, M., Airaksinen, J. et al., Matrix metalloproteinases and their tissue inhibitors in aqueous humor of patients with primary open-angle glaucoma, exfoliation syndrome, and exfoliation glaucoma. J. Glaucoma 2005, 14, 64-69.
13. Tripathi, R. C., Millard, C. B., Tripathi, B. J., Protein-composition of human aqueous-humor - SDS-PAGE analysis of surgical and post-mortem samples. Exp. Eye Res. 1989, 48, 117-130.
14. Millard, C. B., Tripathi, B. J., Tripathi, R. C., Detection of glycated polypeptides in human aqueous-humor by lectin-ninding analysis. Exp. Eye Res. 1989, 49, 271-279.
15. Rohde, E., Tomlinson, A. J., Johnson, D. H., Naylor, S., Comparison of protein mixtures in aqueous humor by membrane preconcentration capillary electrophoresis mass spectrometry. Electrophoresis 1998, 19, 2361-2370.
16. Kuchle, M., Nguyen, N. X., Hannappel, E., Naumann, G. O., The blood aqueous barrier in eyes with pseudoexfoliation syndrome. Ophtalmic Res. 1995, 27, 136-142.
17. Brooks, A. M., Gillies, W. E., Fluorescein angiography and fluorophotometry of the iris in pseudoexfoliation of the lens capsule. Br. J. Ophthalmol. 1983, 67, 249-254.
18. Nguyen, N. X., Kuchle, M., Martus, P., Naumann, G. O. H., Quantification of blood-aqueous barrier breakdown after trabeculectomy: Pseudoexfoliation versus primary open-angle glaucoma. J. Glaucoma 1999, 8, 18-23.
19. Schlötzer-Schrehardt, U., Lommatzsch, J., Küchle, M., Konstas, A. G. P. et al., Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2003, 44, 1117-1125.
20. Koliakos, G. G., Konstas, A. G. P., Schlotzer-Schrehardt, U., Hollo, G. et al., Endothelin-1 concentration is increased in the aqueous humour of patients with exfoliation syndrome. Br. J. Ophthalmol. 2004, 88, 523-527.
21. Zenkel, M., Kruse, F. E., Junemann, A. G., Naumann, G. O. H. et al., Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Invest. Ophthalmol. Vis. Sci. 2006, 47, 1982-1990.
22. Koliakos, G. G., Konstas, A. G. P., Dimitrakoulias, N., Triantos, A. et al., Possible role of transferrin in exfoliation syndrome. Acta Ophthalmol. Scand. 1996, 74, 155-159.
23. Inatani, M., Tanihara, H., Katsuta, H., Honjo, M. et al., Transforming growth factor-beta(2) levels in aqueous humor of glaucomatous eyes. Graefes Arch. Clin. Exp. Ophthalmol. 2001, 239, 109-113.
24. Picht, G., Welge-Luessen, U., Grehn, F., Lutjen-Drecoll, E., Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch. Clin. Exp. Ophthalmol. 2001, 239, 199-207.
25. Schlötzer-Schrehardt, U., Zenkel, M., Kuchle, M., Sakai, L. Y. et al., Role of transforming growth factor-beta 1 and its latent form binding protein in pseudoexfoliation syndrome. Exp. Eye Res. 2001, 73, 765-780.
26. Janciauskiene, S., Brandt, L., Wallmark, A., Westin, U. et al., Secreted leukocyte protease inhibitor is present in aqueous humours from cataracts and other eye pathologies. Exp. Eye Res. 2006, 82, 505-511.
27. Ando, H., Twining, S. S., Yue, B. Y. J. T., Zhou, X. Y. et al., MMPs and proteinase-inhibitors in the human aqueous-humor. Invest. Ophthalmol. Vis. Sci. 1993, 34, 3541-3548.
28. Kuchle, M., Ho, T. S., Nguyen, N. X., Hannappel, E. et al., Protein quantification and electrophoresis in aqueous-humor of pseudoexfoliation eyes. Invest. Ophthalmol. Vis. Sci. 1994, 35, 748-752.
29. Berlau, J., Lorenz, P., Beck, R., Makovitzky, J. et al., Analysis of aqueous humour proteins of eyes with and without pseudoexfoliation syndrome. Graefes Arch. Clin. Exp. Ophthalmol. 2001, 239, 743-746.
30. Bradford, M. M., A rapid and sensitive method for quanitation of microgram quantities of proteins utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
31. Bergquist, J., Palmblad, M., Wetterhall, M., Håkansson, P. et al., Peptide mapping of proteins in human body fluids using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. Mass Spectrom. Rev. 2002, 21, 2-15.
32. Miller, J. C., Miller, J. N., Statistics for Analytical Chemistry, Ellis Horwood Ltd., Chichester 1993.
33. Funding, M., Vorum, H., Honore, B., Nexo, E. et al., Proteomic analysis of aqueous humour from patients with acute corneal rejection. Acta Ophthalmol. Scand. 2005, 83, 31-39.
34. Tong, J. P., Chan, W. M., Liu, D. T. L., Lai, T. Y. Y. et al., Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. Am. J. Ophthalmol. 2006, 141, 456-462.
35. Ogata, N., Matsuoka, M., Imaizumi, M., Arichi, M. et al., Decrease of igment epithelium-derived factor in aqueous humor with increasing age. Am. J. Ophthalmol. 2004, 137, 935-936.
36. Janciauskiene, S., Krakau, T., Alzheimer's peptide and serine proteinase inhibitors in glaucoma and exfoliation syndrome. Doc. Ophthalmol. 2003, 106, 215-223.
37. Mann, M., Hojrup, P., Roepstorff, P., Use of mass-spectrometric molecular-weight information to identify proteins in sequence databases. Biol. Mass Spectrom. 1993, 22, 338-345.