Carotid-artery imaging in the diagnosis and management of patients at risk of stroke

The Lancet Neurology

Volumn 8, Issue 6, 2009, Pages 569-580

  U King Im, Jean Marie ^a   Young, Victoria ^a   Gillard, Jonathan H ^a  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ATHEROMA; BLEEDING; CARDIOVASCULAR RISK; CAROTID ARTERY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DIGITAL SUBTRACTION ANGIOGRAPHY; DOPPLER FLOWMETRY; HUMAN; IMAGING SYSTEM; MAGNETIC RESONANCE ANGIOGRAPHY; POSITRON; PRIORITY JOURNAL; REVIEW; STENOSIS; STROKE; THROMBUS;

EID: 65549142572     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(09)70092-4     Document Type: Review

References (119)

1. Murray C.J., and Lopez A.D. Mortality by cause for eight regions of the world: Global Burden of Disease study. Lancet 349 (1997) 1269-1276
2. Fairhead J.F., Mehta Z., and Rothwell P.M. Population-based study of delays in carotid imaging and surgery and the risk of recurrent stroke. Neurology 65 (2005) 371-375
3. Autret A., Pourcelot L., Saudeau D., Marchal C., Bertrand P., and de Boisvilliers S. Stroke risk in patients with carotid stenosis. Lancet 1 (1987) 888-890
4. Meissner I., Wiebers D.O., Whisnant J.P., and O'Fallon W.M. The natural history of asymptomatic carotid artery occlusive lesions. JAMA 258 (1987) 2704-2707
5. Hertzer N.R., Flanagan R.A., Beven E.G., and O'Hara P.J. Surgical versus nonoperative treatment of asymptomatic carotid stenosis. 290 patients documented by intravenous angiography. Ann Surg 204 (1986) 163-171
6. Dennis M.S., Bamford J.M., Sandercock P.A., and Warlow C.P. A comparison of risk factors and prognosis for transient ischemic attacks and minor ischemic strokes. The Oxfordshire Community Stroke Project. Stroke 20 (1989) 1494-1499
7. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351 (1998) 1379-1387
8. Barnett H.J., Taylor D.W., Eliasziw M., et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 339 (1998) 1415-1425
9. Mayberg M.R., Wilson S.E., Yatsu F., et al. Carotid endarterectomy and prevention of cerebral ischemia in symptomatic carotid stenosis. Veterans Affairs Cooperative Studies Program 309 Trialist Group. JAMA 266 (1991) 3289-3294
10. Rothwell P.M., Eliasziw M., Gutnikov S.A., et al. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 361 (2003) 107-116
11. White C.J., Beckman J.A., Cambria R.P., et al. Atherosclerotic Peripheral Vascular Disease Symposium II: controversies in carotid artery revascularization. Circulation 118 (2008) 2852-2859
12. Mayo Asymptomatic Carotid Endarterectomy Study Group. Effectiveness of carotid endarterectomy for asymptomatic carotid stenosis: design of a clinical trial. Mayo Clin Proc 64 (1989) 897-904
13. Perry J.R., Szalai J.P., and Norris J.W. Consensus against both endarterectomy and routine screening for asymptomatic carotid artery stenosis. Canadian Stroke Consortium. Arch Neurol 54 (1997) 25-28
14. Mayo Asymptomatic Carotid Endarterectomy Study Group. Results of a randomized controlled trial of carotid endarterectomy for asymptomatic carotid stenosis. Mayo Clin Proc 67 (1992) 513-518
15. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for asymptomatic carotid artery stenosis. JAMA 273 (1995) 1421-1428
16. Hobson R.W., Weiss D.G., Fields W.S., et al. Efficacy of carotid endarterectomy for asymptomatic carotid stenosis. The Veterans Affairs Cooperative Study Group. N Engl J Med 328 (1993) 221-227
17. Halliday A., Mansfield A., Marro J., et al. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 363 (2004) 1491-1502
18. Connors J.J., Seidenwurm D., Wojak J.C., et al. Treatment of atherosclerotic disease at the cervical carotid bifurcation: current status and review of the literature. AJNR Am J Neuroradiol 21 (2000) 444-450
19. Rothwell P.M., Eliasziw M., Gutnikov S.A., Warlow C.P., and Barnett H.J. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 363 (2004) 915-924
20. Lovett J.K., Dennis M.S., Sandercock P.A., Bamford J., Warlow C.P., and Rothwell P.M. Very early risk of stroke after a first transient ischemic attack. Stroke 34 (2003) e138-e140
21. Rothwell P.M. Does transient ischemic attack deserve emergency care?. Nat Clin Pract Neurol 2 (2006) 174-175
22. Rothwell P.M., Gutnikov S.A., and Warlow C.P. Reanalysis of the final results of the European Carotid Surgery Trial. Stroke 34 (2003) 514-523
23. Rothwell P.M., Gibson R.J., Slattery J., Sellar R.J., and Warlow C.P. Equivalence of measurements of carotid stenosis. A comparison of three methods on 1001 angiograms. European Carotid Surgery Trialists' Collaborative Group. Stroke 25 (1994) 2435-2439
24. Elgersma O.E., Wust A.F., Buijs P.C., van Der Graaf Y., Eikelboom B.C., and Mali W.P. Multidirectional depiction of internal carotid arterial stenosis: three-dimensional time-of-flight MR angiography versus rotational and conventional digital subtraction angiography. Radiology 216 (2000) 511-516
25. Elgersma O.E., Buijs P.C., Wust A.F., van der Graaf Y., Eikelboom B.C., and Mali W.P. Maximum internal carotid arterial stenosis: assessment with rotational angiography versus conventional intraarterial digital subtraction angiography. Radiology 213 (1999) 777-783
26. U-King-Im J., Hollingworth W., Trivedi R.A., et al. Contrast-enhanced MR angiography vs intra-arterial digital subtraction angiography for carotid imaging: activity-based cost analysis. Eur Radiol 14 (2004) 730-735
27. Willinsky R.A., Taylor S.M., TerBrugge K., Farb R.I., Tomlinson G., and Montanera W. Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature. Radiology 227 (2003) 522-528
28. Rothwell P.M., Giles M.F., Chandratheva A., et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 370 (2007) 1432-1442
29. Mani R.L., Eisenberg R.L., McDonald E.J., Pollock J.A., and Mani J.R. Complications of catheter cerebral arteriography: analysis of 5,000 procedures. I. Criteria and incidence. AJR Am J Roentgenol 131 (1978) 861-865
30. Faught E., Trader S.D., and Hanna G.R. Cerebral complications of angiography for transient ischemia and stroke: prediction of risk. Neurology 29 (1979) 4-15
31. Eisenberg R., Bank W., and Hedgcock M. Neurologic complications of angiography for cerebrovascuar disease. Neurology 30 (1980) 895-897
32. Earnest F., Forbes G., Sandok B.A., et al. Complications of cerebral angiography: prospective assessment of risk. AJR Am J Roentgenol 142 (1984) 247-253
33. Dion J.E., Gates P.C., Fox A.J., Barnett H.J., and Blom R.J. Clinical events following neuroangiography: a prospective study. Stroke 18 (1987) 997-1004
34. Skalpe I.O. Complications in cerebral angiography with iohexol (Omnipaque) and meglumine metrizoate (Isopaque cerebral). Neuroradiology 30 (1988) 69-72
35. Grzyska U., Freitag J., and Zeumer H. Selective cerebral intraarterial DSA. Complication rate and control of risk factors. Neuroradiology 32 (1990) 296-299
36. Hankey G.J., Warlow C.P., and Molyneux A.J. Complications of cerebral angiography for patients with mild carotid territory ischaemia being considered for carotid endarterectomy. J Neurol Neurosurg Psychiatry 53 (1990) 542-548
37. Waugh J.R., and Sacharias N. Arteriographic complications in the DSA era. Radiology 182 (1992) 243-246
38. Davies K.N., and Humphrey P.R. Complications of cerebral angiography in patients with symptomatic carotid territory ischaemia screened by carotid ultrasound. J Neurol Neurosurg Psychiatry 56 (1993) 967-972
39. Heiserman J.E., Dean B.L., Hodak J.A., et al. Neurologic complications of cerebral angiography. AJNR Am J Neuroradiol 15 (1994) 1401-1407
40. Eliasziw M., Rankin R.N., Fox A.J., Haynes R.B., and Barnett H.J. Accuracy and prognostic consequences of ultrasonography in identifying severe carotid artery stenosis. North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group. Stroke 26 (1995) 1747-1752
41. Leffers A.M., and Wagner A. Neurologic complications of cerebral angiography. A retrospective study of complication rate and patient risk factors. Acta Radiol 41 (2000) 204-210
42. Johnston D.C., Chapman K.M., and Goldstein L.B. Low rate of complications of cerebral angiography in routine clinical practice. Neurology 57 (2001) 2012-2014
43. Berczi V., Randall M., Balamurugan R., et al. Safety of arch aortography for assessment of carotid arteries. Eur J Vasc Endovasc Surg 31 (2006) 3-7
44. Cloft H.J., Joseph G.J., and Dion J.E. Risk of cerebral angiography in patients with subarachnoid hemorrhage, cerebral aneurysm, and arteriovenous malformation: a meta-analysis. Stroke 30 (1999) 317-320
45. Chen J.C., Salvian A.J., Taylor D.C., Teal P.A., Marotta T.R., and Hsiang Y.N. Predictive ability of duplex ultrasonography for internal carotid artery stenosis of 70%-99%: a comparative study. Ann Vasc Surg 12 (1998) 244-247
46. Mikkonen R.H., Kreula J.M., and Virkkunen P.J. Reproducibility of Doppler ultrasound measurements. Acta Radiol 37 (1996) 545-550
47. Kuntz K.M., Polak J.F., Whittemore A.D., Skillman J.J., and Kent K.C. Duplex ultrasound criteria for the identification of carotid stenosis should be laboratory specific. Stroke 28 (1997) 597-602
48. Perkins J.M., Galland R.B., Simmons M.J., and Magee T.R. Carotid duplex imaging: variation and validation. Br J Surg 87 (2000) 320-322
49. Grant E.G., Benson C.B., Moneta G.L., et al. Carotid artery stenosis: grayscale and Doppler ultrasound diagnosis-Society of Radiologists in Ultrasound consensus conference. Ultrasound Q 19 (2003) 190-198
50. Mathiesen E.B., Joakimsen O., and Bonaa K.H. Inter-sonographer reproducibility and inter-method variability of ultrasound measurements of carotid artery stenosis: the Tromso study. Cerebrovasc Dis 10 (2000) 207-213
51. Wardlaw J.M., Chappell F.M., Best J.J., Wartolowska K., and Berry E. Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet 367 (2006) 1503-1512
52. Nederkoorn P.J., Mali W.P., Eikelboom B.C., et al. Preoperative diagnosis of carotid artery stenosis: accuracy of noninvasive testing. Stroke 33 (2002) 2003-2008
53. Johnston D.C., and Goldstein L.B. Clinical carotid endarterectomy decision making: noninvasive vascular imaging versus angiography. Neurology 56 (2001) 1009-1015
54. Dawson D.L., Roseberry C.A., and Fujitani R.M. Preoperative testing before carotid endarterectomy: a survey of vascular surgeons' attitudes. Ann Vasc Surg 11 (1997) 264-272
55. Berry E., Kelly S., Westwood M.E., et al. The cost-effectiveness of magnetic resonance angiography for carotid artery stenosis and peripheral vascular disease: a systematic review. Health Technol Assess 6 (2002) 1-155
56. Long A., Lepoutre A., Corbillon E., Branchereau A., and Kretz J.G. Modalities of preoperative imaging of the internal carotid artery used in France. Ann Vasc Surg 16 (2002) 261-265
57. Wehrli F.W., Shimakawa A., Gullberg G.T., and MacFall J.R. Time-of-flight MR flow imaging: selective saturation recovery with gradient refocusing. Radiology 160 (1986) 781-785
58. Nederkoorn P.J., van der Graaf Y., Eikelboom B.C., van der Lugt A., Bartels L.W., and Mali W.P. Time-of-flight MR angiography of carotid artery stenosis: does a flow void represent severe stenosis?. AJNR Am J Neuroradiol 23 (2002) 1779-1784
59. Patel M.R., Kuntz K.M., Klufas R.A., et al. Preoperative assessment of the carotid bifurcation. Can magnetic resonance angiography and duplex ultrasonography replace contrast arteriography?. Stroke 26 (1995) 1753-1758
60. Blatter D.D., Bahr A.L., Parker D.L., et al. Cervical carotid MR angiography with multiple overlapping thin-slab acquisition: comparison with conventional angiography. AJR Am J Roentgenol 161 (1993) 1269-1277
61. Nederkoorn P.J., Van Der Graaf Y., Hunink M.G., Forsting M., and Wanke I. Duplex ultrasound and magnetic resonance angiography compared with digital subtraction angiography in carotid artery stenosis: a systematic review. Stroke 34 (2003) 1324-1332
62. Masaryk T.J., Modic M.T., Ruggieri P.M., et al. Three-dimensional (volume) gradient-echo imaging of the carotid bifurcation: preliminary clinical experience. Radiology 171 (1989) 801-806
63. Kallmes D.F., Omary R.A., Dix J.E., Evans A.J., and Hillman B.J. Specificity of MR angiography as a confirmatory test of carotid artery stenosis. Am J Neuroradiol 17 (1996) 1501-1506
64. Prince M.R. Contrast-enhanced MR angiography: theory and optimization. Magn Reson Imaging Clin N Am 6 (1998) 257-267
65. Ersoy H., Watts R., Sanelli P., et al. Atherosclerotic disease distribution in carotid and vertebrobasilar arteries: Clinical experience in 100 patients undergoing fluoro-triggered 3D Gd-MRA. J Magn Reson Imaging 17 (2003) 545-558
66. Wutke R., Lang W., Fellner C., et al. High-resolution, contrast-enhanced magnetic resonance angiography with elliptical centric k-space ordering of supra-aortic arteries compared with selective X-ray angiography. Stroke 33 (2002) 1522-1529
67. Randoux B., Marro B., Koskas F., et al. Carotid artery stenosis: prospective comparison of CT, three-dimensional gadolinium-enhanced MR, and conventional angiography. Radiology 220 (2001) 179-185
68. Serfaty J.M., Chirossel P., Chevallier J.M., Ecochard R., Froment J.C., and Douek P.C. Accuracy of three-dimensional gadolinium-enhanced MR angiography in the assessment of extracranial carotid artery disease. AJR Am J Roentgenol 175 (2000) 455-463
69. Huston III J., Fain S.B., Riederer S.J., Wilman A.H., Bernstein M.A., and Busse R.F. Carotid arteries: maximizing arterial to venous contrast in fluoroscopically triggered contrast-enhanced MR angiography with elliptic centric view ordering. Radiology 211 (1999) 265-273
70. Sardanelli F., Zandrino F., Parodi R.C., and De Caro G. MR angiography of internal carotid arteries: breath-hold Gd-enhanced 3D fast imaging with steady-state precession versus unenhanced 2D and 3D time-of-flight techniques. J Comput Assist Tomogr 23 (1999) 208-215
71. Cloft H.J., Murphy K.J., Prince M.R., and Brunberg J.A. 3D gadolinium-enhanced MR angiography of the carotid arteries. Magn Reson Imaging 14 (1996) 593-600
72. Willinek W.A., Gieseke J., von Falkenhausen M., et al. Sensitivity encoding (SENSE) for high spatial resolution time-of-flight MR angiography of the intracranial arteries at 3.0 T. Rofo 176 (2004) 21-26
73. Hadizadeh D.R., Gieseke J., Lohmaier S.H., et al. Peripheral MR angiography with blood pool contrast agent: prospective intraindividual comparative study of high-spatial-resolution steady-state MR angiography versus standard-resolution first-pass MR angiography and DSA. Radiology 249 (2008) 701-711
74. Corti R., Ferrari C., Roberti M., Alerci M., Pedrazzi P.L., and Gallino A. Spiral computed tomography: a novel diagnostic approach for investigation of the extracranial cerebral arteries and its complementary role in duplex ultrasonography. Circulation 98 (1998) 984-989
75. Alvarez-Linera J., Benito-Leon J., Escribano J., Campollo J., and Gesto R. prospective evaluation of carotid artery stenosis: elliptic centric contrast-enhanced mr angiography and spiral CT angiography compared with digital subtraction angiography. AJNR Am J Neuroradiol 24 (2003) 1012-1019
76. Norris J.W., and Rothwell P.M. Noninvasive carotid imaging to select patients for endarterectomy: is it really safer than conventional angiography?. Neurology 56 (2001) 990-991
77. Davis S.M., and Donnan G.A. Is carotid angiography necessary? Editors disagree. Stroke 34 (2003) 1819
78. Rothwell P.M., Pendlebury S.T., Wardlaw J., and Warlow C.P. Critical appraisal of the design and reporting of studies of imaging and measurement of carotid stenosis. Stroke 31 (2000) 1444-1450
79. Loftus I.M., McCarthy M.J., and Pau H. Carotid endarterectomy without angiography does not compromise ioperative outcome. Eur J Vasc Endovasc Surg 16 (1998) 489-493
80. Logason K., Karacagil S., and Hardermark H. Carotid endarterctomy soley based on duplex scan findings. Eur J Vasc Endovasc Surg 36 (2002) 9-15
81. Johnston D.C., Eastwood J.D., Nguyen T., and Goldstein L.B. Contrast-enhanced magnetic resonance angiography of carotid arteries: utility in routine clinical practice. Stroke 33 (2002) 2834-2838
82. Berg M.H., Manninen H.I., Rasanen H.T., Vanninen R.L., and Jaakkola P.A. CT angiography in the assessment of carotid artery atherosclerosis. Acta Radiol 43 (2002) 116-124
83. Athanasoulis C.A., and Plomaritoglou A. Preoperative imaging of the carotid bifurcation. Current trends. Int Angiol 19 (2000) 1-7
84. Osarumwense D., Pararajasingham R., Wilson P., Abraham J., and Walker S. Carotid artery imaging in the United Kingdom: a postal questionnaire of current practice. Vascular 13 (2005) 173-177
85. Robless P., and Halliday A. Vascular Surgical Society of Great Britain and Ireland: carotid angiography is used more selectively in the Asymptomatic Carotid Surgery Trial. Br J Surg 86 (1999) 690-691
86. U-King-Im J., Trivedi R.A., Graves M.J., et al. Contrast-enhanced MR angiography for carotid disease: diagnostic and potential clinical impact. Neurology 62 (2004) 1282-1290
87. Bossuyt P.M., Reitsma J.B., Bruns D.E., et al. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ 326 (2003) 41-44
88. U-King-Im J., Hollingworth W., Trivedi R., et al. Cost-effectiveness of diagnostic strategies prior to carotid endarterectomy. Ann Neurol 58 (2005) 506-515
89. Buskens E., Nederkoorn P.J., Der Woude T.B., et al. Imaging of carotid arteries in symptomatic patients: cost-effectiveness of diagnostic strategies. Radiology 233 (2004) 101-112
90. Wardlaw J.M., Chappell F.M., Stevenson M., et al. Accurate, practical and cost-effective assessment of carotid stenosis in the UK. Health Technol Assess 10 (2006) 1-182
91. Bartlett E.S., Walters T.D., Symons S.P., and Fox A.J. Diagnosing carotid stenosis near-occlusion by using CT angiography. AJNR Am J Neuroradiol 27 (2006) 632-637
92. Fox A.J., Eliasziw M., Rothwell P.M., Schmidt M.H., Warlow C.P., and Barnett H.J. Identification, prognosis, and management of patients with carotid artery near occlusion. AJNR Am J Neuroradiol 26 (2005) 2086-2094
93. Demarco J.K., Rutt B.K., and Clarke S.E. Carotid plaque characterization by magnetic resonance imaging: review of the literature. Top Magn Reson Imaging 12 (2001) 205-217
94. Spagnoli L.G., Mauriello A., Sangiorgi G., et al. Extracranial thrombotically active carotid plaque as a risk factor for ischemic stroke. JAMA 292 (2004) 1845-1852
95. Ambrose J.A., Tannenbaum M.A., Alexopoulos D., et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 12 (1988) 56-62
96. Glagov S., Weisenberg E., Zarins C.K., Stankunavicius R., and Kolettis G.J. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316 (1987) 1371-1375
97. Trivedi R.A., U-King-Im J.M., Graves M.J., Gillard J., and Kirkpatrick P.J. Non-stenotic ruptured atherosclerotic plaque causing thrombo-embolic stroke. Cerebrovasc Dis 20 (2005) 53-55
98. Rothwell P.M., Gibson R., Warlow C.P., and on behalf of the European Carotid Surgery Trialists' Collaborative Group. Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. Stroke 31 (2000) 615-621
99. Lovett J.K., Gallagher P.J., Hands L.J., Walton J., and Rothwell P.M. Histological correlates of carotid plaque surface morphology on lumen contrast imaging. Circulation 110 (2004) 2190-2197
100. Wintermark M., Jawadi S.S., Rapp J.H., et al. High-resolution CT imaging of carotid artery atherosclerotic plaques. AJNR Am J Neuroradiol 29 (2008) 875-882
101. Denzel C., Fellner F., Wutke R., Bazler K., Muller K.M., and Lang W. Ultrasonographic analysis of arteriosclerotic plaques in the internal carotid artery. Eur J Ultrasound 16 (2003) 161-167
102. Spence J.D., Tamayo A., Lownie S.P., Ng W.P., and Ferguson G.G. Absence of microemboli on transcranial Doppler identifies low-risk patients with asymptomatic carotid stenosis. Stroke 36 (2005) 2373-2378
103. Sitzer M., Muller W., Siebler M., et al. Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis. Stroke 26 (1995) 1231-1233
104. U-King-Im J.M., Tang T.Y., Patterson A., et al. Characterisation of carotid atheroma in symptomatic and asymptomatic patients using high resolution MRI. J Neurol Neurosurg Psychiatry 79 (2008) 905-912
105. Hatsukami T.S., Ross R., Polissar N.L., and Yuan C. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation 102 (2000) 959-964
106. Yuan C., Zhang S.X., Polissar N.L., et al. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation 105 (2002) 181-185
107. Trivedi R.A., U-King-Im J.M., Graves M.J., et al. Multi-sequence in vivo MRI can quantify fibrous cap and lipid core components in human carotid atherosclerotic plaques. Eur J Vasc Endovasc Surg 28 (2004) 207-213
108. Redgrave J.N., Gallagher P., Lovett J.K., and Rothwell P.M. Critical cap thickness and rupture in symptomatic carotid plaques: the Oxford Plaque Study. Stroke 39 (2008) 1722-1729
109. Cai J.M., Hatsukami T.S., Ferguson M.S., Small R., Polissar N.L., and Yuan C. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation 106 (2002) 1368-1373
110. Moody A.R., Murphy R.E., Morgan P.S., et al. Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia. Circulation 107 (2003) 3047-3052
111. Trivedi R.A., Mallawarachi C., U-King-Im J.M., et al. Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. Arterioscler Thromb Vasc Biol 26 (2006) 1601-1606
112. Virmani R., Burke A., Ladich E., and Kolodgie F.D. Pathology of carotid atherosclerotic disease. In: Gillard J., Graves M., Hatsukami T., and Yuan C. (Eds). Carotid disease: the role of imaging in diagnosis and treatment (2006), Cambridge University Press, Cambridge 1-21
113. Takaya N., Yuan C., Chu B., et al. Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI-initial results. Stroke 37 (2006) 818-823
114. Lovett J.K., Redgrave J.N., and Rothwell P.M. A critical appraisal of the performance, reporting, and interpretation of studies comparing carotid plaque imaging with histology. Stroke 36 (2005) 1091-1097
115. Corti R., Fayad Z.A., Fuster V., et al. Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation 104 (2001) 249-252
116. Rudd J.H., Warburton E.A., Fryer T.D., et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 105 (2002) 2708-2711
117. U-King-Im J.M., Tang T., Moustafa R.R., Baron J.C., Warburton E.A., and Gillard J.H. Imaging the cellular biology of the carotid plaque. Int J Stroke 2 (2007) 85-96
118. Davies J.R., Rudd J.H., Fryer T.D., et al. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 36 (2005) 2642-2647
119. Tahara N., Kai H., Ishibashi M., et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 48 (2006) 1825-1831