메뉴 건너뛰기




Volumn 4, Issue 2, 2009, Pages 150-158

The fusion inhibitor enfuvirtide in recent antiretroviral strategies

Author keywords

Antiretroviral therapy; Enfuvirtide; Fusion inhibitor; HIV

Indexed keywords

DARUNAVIR; DARUNAVIR PLUS RITONAVIR; ENFUVIRTIDE; ETRAVIRINE; LOPINAVIR; MARAVIROC; RALTEGRAVIR; RITONAVIR PLUS TIPRANAVIR; TIPRANAVIR; VICRIVIROC; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GLYCOPROTEIN GP 41; PEPTIDE FRAGMENT;

EID: 65549115032     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0b013e32832498d8     Document Type: Review
Times cited : (28)

References (46)
  • 3
    • 33644834760 scopus 로고    scopus 로고
    • Week-12 response to therapy as a predictor of week 24, 48, and 96 outcome in patients receiving the HIV fusion inhibitor enfuvirtide in the T-20 versus Optimized Regimen only (TORO) trials
    • DOI 10.1086/500206
    • Raffi F, Katlama C, Saag M, et al. Week-12 response to therapy as a predictor of week 24, 48, and 96 outcome in patients receiving the HIV fusion inhibitor enfuvirtide in the T-20 versus Optimized Regimen Only (TORO) trials. Clin Infect Dis 2006; 42:870-877. (Pubitemid 43363947)
    • (2006) Clinical Infectious Diseases , vol.42 , Issue.6 , pp. 870-877
    • Raffi, F.1    Katlama, C.2    Saag, M.3    Wilkinson, M.4    Chung, J.5    Smiley, L.6    Salgo, M.7
  • 4
    • 34447281787 scopus 로고    scopus 로고
    • Primary resistance to enfuvirtide (T20) in recently HIV-1 infected, antiretroviral-naive patients from the ANRS Aquitaine Cohort
    • Peuchant O, Capdepont S, Ragnaud JM, et al. Primary resistance to enfuvirtide (T20) in recently HIV-1 infected, antiretroviral-naive patients from the ANRS Aquitaine Cohort. Antivir Ther 2007; 12:559-562.
    • (2007) Antivir Ther , vol.12 , pp. 559-562
    • Peuchant, O.1    Capdepont, S.2    Ragnaud, J.M.3
  • 5
    • 33846029516 scopus 로고    scopus 로고
    • Increased polymorphism in the HR-1 gp41 env gene encoding the enfuvirtide (T-20) target in HIV-1 variants harboring multiple antiretroviral drug resistance mutations in the pol gene
    • DOI 10.1097/01.qai.0000243118.59906.f4, PII 0012633420070101000001
    • Si-Mohamed A, Piketty C, Tisserand P, et al. Increased polymorphism in the HR-1 gp41 env gene encoding the enfuvirtide (T-20) target in HIV-1 variants harboring multiple antiretroviral drug resistance mutations in the pol gene. J Acquir Immune Defic Syndr 2007; 44:1-5. (Pubitemid 46052213)
    • (2007) Journal of Acquired Immune Deficiency Syndromes , vol.44 , Issue.1 , pp. 1-5
    • Si-Mohamed, A.1    Piketty, C.2    Tisserand, P.3    Legoff, J.4    Weiss, L.5    Charpentier, C.6    Kazatchkine, M.D.7    Belec, L.8
  • 6
    • 42449124874 scopus 로고    scopus 로고
    • Enfuvirtide does not require dose adjustment in patients with chronic kidney failure: Results of a pharmacokinetic study of enfuvirtide in HIV-1-infected patients with impaired kidney function
    • DOI 10.1097/QAI.0b013e31816237f0, PII 0012633420080301000012
    • Tebas P, Bellos N, Lucasti C, et al. Enfuvirtide does not require dose adjustment in patients with chronic kidney failure: results of a pharmacokinetic study of enfuvirtide in HIV-1-infected patients with impaired kidney function. J Acquir Immune Defic Syndr 2008; 47:342-345. (Pubitemid 351619421)
    • (2008) Journal of Acquired Immune Deficiency Syndromes , vol.47 , Issue.3 , pp. 342-345
    • Tebas, P.1    Bellos, N.2    Lucasti, C.3    Richmond, G.4    Godofsky, E.5    Patel, I.6    Chiu, Y.-Y.7    Evans, C.8    Rowell, L.9    Salgo, M.10
  • 9
    • 34548321373 scopus 로고    scopus 로고
    • Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: Sub-analysis from RESIST
    • DOI 10.1097/QAD.0b013e3282ef8600, PII 0000203020070912000021
    • Raffi F, Battegay M, Rusconi S, et al. Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: sub-analysis from RESIST. AIDS 2007; 21:1977-1980. (Pubitemid 47333873)
    • (2007) AIDS , vol.21 , Issue.14 , pp. 1977-1980
    • Raffi, F.1    Battegay, M.2    Rusconi, S.3    Opravil, M.4    Blick, G.5    Steigbigel, R.T.6    Kraft, M.7    Neubacher, D.8    Sabo, J.P.9
  • 15
    • 57049083070 scopus 로고    scopus 로고
    • Safety and efficacy of enfuvirtide in combination with darunavir/ritonavir and an optimized background regimen in triple-class experienced HIV-infected patients: The BLQ study
    • A single-arm trial that evaluates efficacy of darunavir/ritonavir and enfuvirtide in salvage combinations for HIV-multidrug-experienced patients
    • Dejesus E, Gottlieb MS, Gathe JC Jr, et al. Safety and efficacy of enfuvirtide in combination with darunavir/ritonavir and an optimized background regimen in triple-class experienced HIV-infected patients: the BLQ study. Antimicrob Agents Chemother 2008; 52:4315-4319. A single-arm trial that evaluates efficacy of darunavir/ritonavir and enfuvirtide in salvage combinations for HIV-multidrug-experienced patients.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4315-4319
    • Dejesus, E.1    Gottlieb, M.S.2    Gathe Jr., J.C.3
  • 16
    • 34347327010 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
    • DOI 10.1016/S0140-6736(07)61047-2, PII S0140673607610472
    • Madruga JV, Cahn P, Grinsztejn B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007; 370:29-38. A randomized phase III trial that shows high proportions of complete responders with etravirine and darunavir/ritonavir, not enhanced by enfuvirtide when Phenotypic Sensibility Scores at least 2. (Pubitemid 47017466)
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 29-38
    • Madruga, J.V.1    Cahn, P.2    Grinsztejn, B.3    Haubrich, R.4    Lalezari, J.5    Mills, A.6    Pialoux, G.7    Wilkin, T.8    Peeters, M.9    Vingerhoets, J.10    De Smedt, G.11    Leopold, L.12    Trefiglio, R.13    Woodfall, B.14
  • 17
    • 34347354196 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
    • DOI 10.1016/S0140-6736(07)61048-4, PII S0140673607610484
    • Lazzarin A, Campbell T, Clotet B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007; 370:39-48. A randomized phase III trial that shows high proportions of complete responders with etravirine and darunavir/ritonavir, not enhanced by enfuvirtide when Phenotypic Sensibility Scores at least 2. (Pubitemid 47017467)
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 39-48
    • Lazzarin, A.1    Campbell, T.2    Clotet, B.3    Johnson, M.4    Katlama, C.5    Moll, A.6    Towner, W.7    Trottier, B.8    Peeters, M.9    Vingerhoets, J.10    De Smedt, G.11    Baeten, B.12    Beets, G.13    Sinha, R.14    Woodfall, B.15
  • 18
    • 47949120697 scopus 로고    scopus 로고
    • Raltegravir with optimized background therapy for resistant HIV-1 infection
    • Steigbigel RT, Cooper DA, Kumar PN, et al. Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med 2008; 359:339-354.
    • (2008) N Engl J Med , vol.359 , pp. 339-354
    • Steigbigel, R.T.1    Cooper, D.A.2    Kumar, P.N.3
  • 19
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Results of the subgroup analysis of the two BENCHMRK studies, which show enhanced virological responses with enfuvirtide (or darunavir)
    • Cooper DA, Steigbigel RT, Gatell JM, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 2008; 359:355-365. Results of the subgroup analysis of the two BENCHMRK studies, which show enhanced virological responses with enfuvirtide (or darunavir).
    • (2008) N Engl J Med , vol.359 , pp. 355-365
    • Cooper, D.A.1    Steigbigel, R.T.2    Gatell, J.M.3
  • 20
    • 68049103736 scopus 로고    scopus 로고
    • Vicriviroc in combination therapy with an optimized antiretroviral regimen for treatment-experienced subjects: The VICTOR-E1 trial
    • [abstract #795]. A phase II vicriviroc study that shows increased virological responses with enfuvirtide, even when two other fully active drugs, including vicriviroc, are present
    • Zingman B, Suleiman J, DeJesus E, et al. Vicriviroc in combination therapy with an optimized antiretroviral regimen for treatment-experienced subjects: the VICTOR-E1 trial [abstract #795]. In: 15th Conference on Retroviruses and Opportunistic Infections 2008; Boston, Massachusetts; 3-6 February 2008. A phase II vicriviroc study that shows increased virological responses with enfuvirtide, even when two other fully active drugs, including vicriviroc, are present.
    • 15th Conference on Retroviruses and Opportunistic Infections 2008; Boston, Massachusetts; 3-6 February 2008.
    • Zingman, B.1    Suleiman, J.2    DeJesus, E.3
  • 21
    • 54849146700 scopus 로고    scopus 로고
    • Maraviroc for previously treated patients with R5 HIV-1 infection
    • Gulick RM, Lalezari J, Goodrich J, et al. Maraviroc for previously treated patients with R5 HIV-1 infection. N Engl J Med 2008; 359:1429-1441.
    • (2008) N Engl J Med , vol.359 , pp. 1429-1441
    • Gulick, R.M.1    Lalezari, J.2    Goodrich, J.3
  • 22
    • 54849145400 scopus 로고    scopus 로고
    • Subgroup analyses of maraviroc in previously treated R5 HIV-1 infection
    • A phase III trial of maraviroc that demonstrates that first-time use of enfuvirtide in patients with no history of enfuvirtide use, compared with placebo arm, is statistically associated with a favourable virological outcome
    • Fatkenheuer G, Nelson M, Lazzarin A, et al. Subgroup analyses of maraviroc in previously treated R5 HIV-1 infection. N Engl J Med 2008; 359:1442-1455. A phase III trial of maraviroc that demonstrates that first-time use of enfuvirtide in patients with no history of enfuvirtide use, compared with placebo arm, is statistically associated with a favourable virological outcome.
    • (2008) N Engl J Med , vol.359 , pp. 1442-1455
    • Fatkenheuer, G.1    Nelson, M.2    Lazzarin, A.3
  • 25
    • 41349120911 scopus 로고    scopus 로고
    • Placental transfer of enfuvirtide in the ex vivo human placenta perfusion model
    • Ceccaldi PF, Ferreira C, Gavard L, et al. Placental transfer of enfuvirtide in the ex vivo human placenta perfusion model. Am J Obstet Gynecol 2008; 198:433 e1-433 e2.
    • (2008) Am J Obstet Gynecol , vol.198
    • Ceccaldi, P.F.1    Ferreira, C.2    Gavard, L.3
  • 29
    • 56649119165 scopus 로고    scopus 로고
    • A randomized, controlled study evaluating an induction treatment strategy in which enfuvirtide was added to an oral, highly active antiretroviral therapy regimen in treatment-experienced patients: The INTENSE study
    • Clotet B, Capetti A, Soto-Ramirez LE, et al. A randomized, controlled study evaluating an induction treatment strategy in which enfuvirtide was added to an oral, highly active antiretroviral therapy regimen in treatment- experienced patients: the INTENSE study. J Antimicrob Chemother 2008; 62:1374-1378.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 1374-1378
    • Clotet, B.1    Capetti, A.2    Soto-Ramirez, L.E.3
  • 31
    • 70349532901 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive patients infected with R5 HIV 1: Week 48 results of the MERIT study
    • Saag M, Ive P, Heera J, et al. A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive patients infected with R5 HIV 1: week 48 results of the MERIT study. In: 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention 2007; Sydney, Australia; 22-25 July 2007.
    • 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention 2007; Sydney, Australia; 22-25 July 2007
    • Saag, M.1    Ive, P.2    Heera, J.3
  • 32
    • 50949112147 scopus 로고    scopus 로고
    • Outcomes of multidrug-resistant patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen
    • Harris M, Larsen G, Montaner JS. Outcomes of multidrug-resistant patients switched from enfuvirtide to raltegravir within a virologically suppressive regimen. AIDS 2008; 22:1224-1226.
    • (2008) AIDS , vol.22 , pp. 1224-1226
    • Harris, M.1    Larsen, G.2    Montaner, J.S.3
  • 33
    • 63849328771 scopus 로고    scopus 로고
    • Pilot study of switching enfuvirtide to raltegravir in HIV-1 positive patients well controlled on an enfuvirtide based regimen
    • A pilot study, prospective, of raltegravir switch to enfuvirtide without modification of background ART
    • Towner W, Klein D, Follansbee S, et al. Pilot study of switching enfuvirtide to raltegravir in HIV-1 positive patients well controlled on an enfuvirtide based regimen. In: XVII International AIDS Conference; Mexico; 3-8 August 2008. A pilot study, prospective, of raltegravir switch to enfuvirtide without modification of background ART.
    • XVII International AIDS Conference; Mexico; 3-8 August 2008.
    • Towner, W.1    Klein, D.2    Follansbee, S.3
  • 36
    • 4143148495 scopus 로고    scopus 로고
    • Immunological and virological study of enfuvirtide-treated HIV-positive patients
    • DOI 10.1097/01.aids.0000131350.22032.b5
    • Barretina J, Blanco J, Bonjoch A, et al. Immunological and virological study of enfuvirtide-treated HIV-positive patients. AIDS 2004; 18:1673-1682. (Pubitemid 39095784)
    • (2004) AIDS , vol.18 , Issue.12 , pp. 1673-1682
    • Barretina, J.1    Blanco, J.2    Bonjoch, A.3    Llano, A.4    Clotet, B.5    Este, J.A.6
  • 37
    • 46449102432 scopus 로고    scopus 로고
    • Early changes in T-cell activation predict antiretroviral success in salvage therapy of HIV infection
    • Shepard BD, Loutfy MR, Raboud J, et al. Early changes in T-cell activation predict antiretroviral success in salvage therapy of HIV infection. J Acquir Immune Defic Syndr 2008; 48:149-155.
    • (2008) J Acquir Immune Defic Syndr , vol.48 , pp. 149-155
    • Shepard, B.D.1    Loutfy, M.R.2    Raboud, J.3
  • 39
    • 34447121955 scopus 로고    scopus 로고
    • Site-specific mutations in HIV-1 gp41 reveal a correlation between HIV-1-mediated bystander apoptosis and fusion/hemifusion
    • DOI 10.1074/jbc.M701701200
    • Garg H, Joshi A, Freed EO, Blumenthal R. Site-specific mutations in HIV-1 gp41 reveal a correlation between HIV-1-mediated bystander apoptosis and fusion/hemifusion. J Biol Chem 2007; 282:16899-16906. (Pubitemid 47093247)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.23 , pp. 16899-16906
    • Garg, H.1    Joshi, A.2    Freed, E.O.3    Blumenthal, R.4
  • 40
    • 25144500649 scopus 로고    scopus 로고
    • Stoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1
    • DOI 10.1128/JVI.79.19.12132-12147.2005
    • Yang X, Kurteva S, Ren X, et al. Stoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1. J Virol 2005; 79:12132-12147. (Pubitemid 41348726)
    • (2005) Journal of Virology , vol.79 , Issue.19 , pp. 12132-12147
    • Yang, X.1    Kurteva, S.2    Ren, X.3    Lee, S.4    Sodroski, J.5
  • 41
    • 36348936125 scopus 로고    scopus 로고
    • Association between specific enfuvirtide resistance mutations and CD4 cell response during enfuvirtide-based therapy
    • Melby TE, Despirito M, Demasi RA, et al. Association between specific enfuvirtide resistance mutations and CD4 cell response during enfuvirtide-based therapy. AIDS 2007; 21:2537-2539.
    • (2007) AIDS , vol.21 , pp. 2537-2539
    • Melby, T.E.1    Despirito, M.2    Demasi, R.A.3
  • 43
    • 49749114865 scopus 로고    scopus 로고
    • HIV-1-infected patients from the French National Observatory experiencing virological failure while receiving enfuvirtide
    • Descamps D, Assoumou L, Masquelier B, et al. HIV-1-infected patients from the French National Observatory experiencing virological failure while receiving enfuvirtide. J Antimicrob Chemother 2008; 62:451-455.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 451-455
    • Descamps, D.1    Assoumou, L.2    Masquelier, B.3
  • 44
    • 33947417638 scopus 로고    scopus 로고
    • Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors
    • DOI 10.1128/JVI.02413-06
    • Ray N, Harrison JE, Blackburn LA, et al. Clinical resistance to enfuvirtide does not affect susceptibility of human immunodeficiency virus type 1 to other classes of entry inhibitors. J Virol 2007; 81:3240-3250. (Pubitemid 46456633)
    • (2007) Journal of Virology , vol.81 , Issue.7 , pp. 3240-3250
    • Ray, N.1    Harrison, J.E.2    Blackburn, L.A.3    Martin, J.N.4    Deeks, S.G.5    Doms, R.W.6
  • 46
    • 45749137863 scopus 로고    scopus 로고
    • A randomized study to evaluate injection site reactions using three different enfuvirtide delivery mechanisms (the OPTIONS study)
    • Boyd MA, Truman M, Hales G, et al. A randomized study to evaluate injection site reactions using three different enfuvirtide delivery mechanisms (the OPTIONS study). Antivir Ther 2008; 13:449-453. A quality-of-life and site-reaction study that evaluates three different enfuvirtide delivery mechanisms. (Pubitemid 352022554)
    • (2008) Antiviral Therapy , vol.13 , Issue.3 , pp. 449-453
    • Boyd, M.A.1    Truman, M.2    Hales, G.3    Anderson, J.4    Dwyer, D.E.5    Carr, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.