OCT4A contributes to the stemness and multi-potency of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs)

Biochemical and Biophysical Research Communications

Volumn 384, Issue 1, 2009, Pages 120-125

  Seo, Kwang Won ^a,b   Lee, Sae Rom ^a,b   Bhandari, Dilli Ram ^a,b   Roh, Kyoung Hwan ^a,b   Park, Sang Bum ^a,b   So, Ah Young ^a,b   Jung, Ji Won ^a,b   Seo, Min Soo ^a,b   Kang, Soo Kyung ^a,b   Lee, Yong Soon ^a,b   Kang, Kyung Sun ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Multi potency; OCT4; shRNA; Stemness; Umbilical cord blood derived mesenchymal stem cells

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 4; LENTIVIRUS VECTOR; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REX1; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ADIPOGENESIS; ARTICLE; CELL CLONE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DTX1 GENE; EMBRYO; EMBRYONIC STEM CELL; GENE; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; MULTIPOTENT STEM CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; UMBILICAL CORD BLOOD; UPREGULATION;

ADIPOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FETAL BLOOD; GENE EXPRESSION; HUMANS; MULTIPOTENT STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3;

EID: 65549110625     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.04.094     Document Type: Article

References (23)

1. Erices A., Conget P., and Minguell J.J. Mesenchymal progenitor cells in human umbilical cord blood. Br. J. Haematol. 109 (2000) 235-242
2. Gronthos S., Franklin D.M., Leddy H.A., Robey P.G., Storms R.W., and Gimble J.M. Surface protein characterization of human adipose tissue-derived stromal cells. J. Cell. Physiol. 189 (2001) 54-63
3. Campagnoli C., Roberts I.A., Kumar S., Bennett P.R., Bellantuono I., and Fisk N.M. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 98 (2001) 2396-2402
4. Tsai M.S., Lee J.L., Chang Y.J., and Hwang S.M. Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum. Reprod. 19 (2004) 1450-1456
5. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 (1997) 71-74
6. Pittenger M., Vanguri P., Simonetti D., and Young R. Adult mesenchymal stem cells: potential for muscle and tendon regeneration and use in gene therapy. J. Musculoskelet. Neuronal Interact. 2 (2002) 309-320
7. Makino S., Fukuda K., Miyoshi S., Konishi F., Kodama H., Pan J., Sano M., Takahashi T., Hori S., Abe H., Hata J., Umezawa A., and Ogawa S. Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103 (1999) 697-705
8. Phinney D.G., and Isakova I. Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system. Curr. Pharm. Des. 11 (2005) 1255-1265
9. Tropel P., Platet N., Platel J.C., Noel D., Albrieux M., Benabid A.L., and Berger F. Functional neuronal differentiation of bone marrow-derived mesenchymal stem cells. Stem Cells 24 (2006) 2868-2876
10. Bhatia R., and Hare J.M. Mesenchymal stem cells: future source for reparative medicine. Congest. Heart Fail. 11 (2005) 87-91 (quiz 92-83)
11. Pan G.J., Chang Z.Y., Scholer H.R., and Pei D. Stem cell pluripotency and transcription factor Oct4. Cell Res. 12 (2002) 321-329
12. Lengner C.J., Camargo F.D., Hochedlinger K., Welstead G.G., Zaidi S., Gokhale S., Scholer H.R., Tomilin A., and Jaenisch R. Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cells 1 (2007) 403-415
13. Kotoula V., Papamichos S.I., and Lambropoulos A.F. Revisiting OCT4 expression in peripheral blood mononuclear cells. Stem Cells 26 (2008) 290-291
14. Lengner C.J., Welstead G.G., and Jaenisch R. The pluripotency regulator Oct4: a role in somatic stem cells?. Cell Cycle 7 (2008) 725-728
15. Okamoto T., Aoyama T., Nakayama T., Nakamata T., Hosaka T., Nishijo K., Nakamura T., Kiyono T., and Toguchida J. Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells. Biochem. Biophys. Res. Commun. 295 (2002) 354-361
16. Baksh D., Yao R., and Tuan R.S. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 25 (2007) 1384-1392
17. Liedtke S., Enczmann J., Waclawczyk S., Wernet P., and Kogler G. Oct4 and its pseudogenes confuse stem cell research. Cell Stem Cells 1 (2007) 364-366
18. Murphy M., Stinnakre M.G., Senamaud-Beaufort C., Winston N.J., Sweeney C., Kubelka M., Carrington M., Brechot C., and Sobczak-Thepot J. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 15 (1997) 83-86
19. Izon D.J., Aster J.C., He Y., Weng A., Karnell F.G., Patriub V., Xu L., Bakkour S., Rodriguez C., Allman D., and Pear W.S. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity 16 (2002) 231-243
20. Garces C., Ruiz-Hidalgo M.J., Font de Mora J., Park C., Miele L., Goldstein J., Bonvini E., Porras A., and Laborda J. Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J. Biol. Chem. 272 (1997) 29729-29734
21. Lagace D.C., and Nachtigal M.W. Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis. J. Biol. Chem. 279 (2004) 18851-18860
22. Chew J.L., Loh Y.H., Zhang W., Chen X., Tam W.L., Yeap L.S., Li P., Ang Y.S., Lim B., Robson P., and Ng H.H. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol. Cell. Biol. 25 (2005) 6031-6046
23. Campbell P.A., Perez-Iratxeta C., Andrade-Navarro M.A., and Rudnicki M.A. Oct4 targets regulatory nodes to modulate stem cell function. PLoS ONE 2 (2007) e553