A convenient access to furo[3,2-c]pyridin-6(5H)-ones by the reaction of 5-iodo-4-methoxy-2-pyridones with terminal alkynes under microwave-enhanced Sonogashira conditions

Tetrahedron Letters

Volumn 50, Issue 26, 2009, Pages 3299-3301

  Conreaux, David ^a   Delaunay, Thierry ^a   Desbordes, Philippe ^b   Monteiro, Nuno ^a   Balme, Geneviève ^a  

^a UNIVERSITÉ LYON 1   (France)

^b BAYER AG   (Germany)

Author keywords

Alkynes; Annulation; Furopyridinones; Microwave assisted synthesis; Sonogashira cross coupling

Indexed keywords

ALKYNE; FURAN; PYRIDINE DERIVATIVE; PYRIDONE DERIVATIVE; REAGENT;

ANNULATION REACTION; ARTICLE; CATALYST; CHEMICAL PARAMETERS; CHEMICAL STRUCTURE; DEALKYLATION; DEMETHYLATION; MICROWAVE IRRADIATION; ONE POT SYNTHESIS; SONOGASHIRA REACTION;

EID: 65549109834     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.02.073     Document Type: Article

References (12)

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8. 3): δ 1.37 (t, J = 7.2 Hz, 3H), 3.76 (s, OMe), 4.36 (q, J = 7.2 Hz, 2H), 5.15 (s, 2H), 6.14 (d, J = 7.7 Hz, 1H), 7.30-7.35 (m, 5H), 7.39 (d, J = 7.7 Hz, 1H), 7.55 (d, J = 8.5 Hz, 2H), 8.09 (d, J = 8.5 Hz, 2H).
9. 3): δ 1.39 (t, J = 7.1 Hz, 3H), 3.35 (s, OMe), 4.37 (q, J = 7.1 Hz, 2H), 5.09 (s, 2H), 7.30-7.35 (m, 5H); 7.55 (d, J = 6.7 Hz, 2H), 7.69 (s, 1H), 8.07 (d, J = 6.7 Hz, 2H).
10. 2) to give the corresponding furopyridone.
11. 2) to give the corresponding furopyridone.
12. 3)