Comparison Between Vacuum Sublimed Matrices and Conventional Dried Droplet Preparation in MALDI-TOF Mass Spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 20, Issue 6, 2009, Pages 1104-1114

  Jaskolla, Thorsten W ^a   Karas, Michael ^a   Roth, Udo ^b   Steinert, Kerstin ^b   Menzel, Christoph ^b   Reihs, Karsten ^c  

^a GOETHE UNIVERSITY   (Germany)

^b QIAGEN GMBH   (Germany)

^c AMF GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTE; CINNAMIC ACID DERIVATIVES; CINNAMIC ACIDS; EFFECTIVE TEMPERATURES; GAS-PHASE; GRAIN SIZES; HEAT DISSIPATIONS; INITIAL VELOCITIES; ION ENERGIES; ION VELOCITIES; LASER FLUENCES; MALDI-TOF MASS SPECTROMETRIES; MALDI-TOF MS; MATRIX GRAIN SIZES; MATRIX LAYERS; MATRIX-ASSISTED LASER DESORPTION IONIZATIONS; PREPARATION METHODS; TIME-OF FLIGHT MASS SPECTROMETRIES; UNIFORM CRYSTALS; VOLATILIZATION PROCESS;

ACIDS; DESORPTION; DROP FORMATION; GRAIN SIZE AND SHAPE; IONIZATION OF GASES; MASS SPECTROMETERS; MASS SPECTROMETRY; POLYACRYLATES; SELF ASSEMBLY; SPECTRUM ANALYSIS; VACUUM;

IONS;

CINNAMIC ACID;

ARTICLE; COMPARATIVE STUDY; CORRELATION ANALYSIS; CRYSTAL; ENERGY; GAS; GRAIN; HEAT; LASER; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MORPHOLOGY; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; TEMPERATURE; THERMOGRAVIMETRY; VACUUM; VELOCITY; VOLATILIZATION;

CINNAMATES; CRYSTALLIZATION; INSULIN; LASERS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; PEPTIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEMPERATURE; THERMOGRAVIMETRY; VACUUM;

EID: 65549105934     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.02.010     Document Type: Article

References (32)

1. Karas M., Bachmann D., and Hillenkamp F. The Influence of the Wavelength in High Irradiance Ultraviolet Laser Desorption Mass Spectrometry of Organic Molecules. Anal. Chem. 57 (1985) 2935-2939
2. Karas M., Bachmann D., Bahr U., and Hillenkamp F. Matrix-assisted Ultraviolet Laser Desorption of Nonvolatile Compounds. Int. J. Mass Spectrom. Ion Processes 78 (1987) 53-56
3. Karas M., and Hillenkamp F. Laser Desorption Ionization of Proteins with Molecular Masses Exceeding 10,000 Dalton. Anal. Chem. 60 (1988) 2299-2301
4. Miliotis T., Kjellström S., Nilsson J., Laurell T., Edholm L.-E., and Marko-Varga G. Ready-Made Matrix-Assisted Laser Desorption/Ionization Target Plates Coated with Thin Matrix Layer for Automated Sample Deposition in High-Density Array Format. Rapid Commun. Mass Spectrom. 16 (2002) 117-126
5. Haddleton D.M., Waterson C., and Derrick P.J. Comment: A Simple, Low-Cost, Air-Spray Method for Improved Sample Preparation for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Derivatized Poly(Ethylene Glycol). Eur. Mass Spectrom 4 (1998) 203-207
6. Axelsson J., Hoberg A.-M., Waterson C., Myatt P., Shield G.L., Varney J., Haddleton D.M., and Derrick P.J. Improved Reproducibility and Increased Signal Intensity in Matrix-Assisted Laser Desorption/Ionization as a Result of Electrospray Sample Preparation. Rapid Commun. Mass Spectrom. 11 (1997) 209-213
7. Preisler J., Foret F., and Karger B.L. On-Line MALDI-TOF MS Using a Continuous Vacuum Deposition Interface. Anal. Chem. 70 (1998) 5278-5287
8. Preisler J., Hu P., Rejtar T., and Karger B.L. Capillary Electrophoresis-Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Using a Vacuum Deposition Interface. Anal. Chem. 72 (2000) 4785-4795
9. Preisler J., Hu P., Rejtar T., Moskovets E., and Karger B.L. Capillary Array Electrophoresis-MALDI Mass Spectrometry Using a Vacuum Deposition Interface. Anal. Chem. 74 (2002) 17-25
10. Hankin J.A., Barkley R.M., and Murphy R.C. Sublimation as a Method of Matrix Application for Mass Spectrometric Imaging. J. Am. Soc. Mass Spectrom. 18 (2007) 1646-1652
11. Reihs K., Engelking J., Harder P., Nordhoff E., Röhl H., Rudakowski S., Vorberg K., and Wesener J. Ready-Made MALDI Target Plates Containing High-Density Arrays of Vacuum-Deposited Matrix Spots on Ultraphobic Surfaces. Proceedings of the 51st ASMS Conference on Mass Spectrometry and Allied Topics (June, 2003) Montreal, Canada
12. Muscate-Magnussen A., Zhu X., Wesener J., Röhl H., Harder P., and Reihs K. A New Approach of Liquid Sample Handling on MALDI Plates Enabling Advanced High Throughput Proteomics Applications. Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics (May, 2004) Nashville, TN
13. Röhl H., Goethel S., Pickartz J., Wesener J., and Reihs K. Depth Profiling of CHCA Matrix Spots for the Investigation of Sensitivity and Dynamic Range of Peptide Analysis by MALDI-TOF MS. Proceedings of the 53rd ASMS Conference on Mass Spectrometry and Allied Topics (June, 2005) San Antonio, TX
14. Röhl H., Goethel S., and Reihs K. MPep MALDI Chips for High-Sensitivity and High-Throughput Peptide Analysis by MALDI-TOF MS. Nature Methods 2 (2005) 6 (Application Note)
15. Jaskolla T., Roth U., Röhl H., Glückmann M., Karas M., Steinert K., and Reihs K. Sensitive and Reproducible Detection of Peptides by MALDI-TOF MS Using Self-Assembled Monolayer (SAM)-Based Chips-Specifications and Applications. Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics (May, 2006) Seattle, WA
16. Jaskolla T., Karas M., Steinert K., Roth U., Menzel C., and Reihs K. Effects of Matrix Crystal Size on Ion Formation in Matrix-Assisted Laser Desorption/Ionization. Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics (June, 2007) Indianapolis, IN
17. Poetsch A., Schlüsener D., Florizone C., Eltis L., Menzel C., Rögner M., Steinert K., and Roth U. Improved Identification of Membrane Proteins by MALDI-TOF MS/MS Using Vacuum Sublimated Matrix Spots on an Ultraphobic Chip Surface. J. Biomol. Tech. 19 (2008) 129-138
18. Önnerfjord P., Ekström S., Bergquist J., Nilsson J., Laurell T., and Marko-Varga G. Homogeneous Sample Preparation for Automated High Throughput Analysis with Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 13 (1999) 315-322
19. Gabelica V., Schulz E., and Karas M. Internal Energy Build-Up in Matrix-Assisted Laser Desorption/Ionization. J. Mass Spectrom. 39 (2004) 579-593
20. Jaskolla T.W., Lehmann W.D., and Karas M. 4-Chloro-α-Cyanocinnamic Acid Is an Advanced, Rationally Designed MALDI Matrix. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 12200-12205
21. Owen S.J., Meier F.S., Brombacher S., and Volmer D. Increasing Sensitivity and Decreasing Spot Size Using an Inexpensive, Removable Hydrophobic Coating for Matrix-Assisted Laser Desorption/Ionization Plates. Rapid Commun. Mass Spectrom. 17 (2003) 2439-2449
22. Jaskolla T.W., and Karas M. Using Fluorescence Dyes as a Tool for Analyzing the MALDI Process. J. Am. Soc. Mass Spectrom. 19 (2008) 1054-1061
23. Luo G., Marginean I., and Vertes A. Internal Energy of Ions Generated by Matrix-Assisted Laser Desorption/Ionization. Anal. Chem. 74 (2002) 6185-6190
24. Sadeghi M., and Vertes A. Crystallite Size Dependence of Volatilization in Matrix-Assisted Laser Desorption Ionization. Appl. Surf. Sci 127/129 (1998) 226-234
25. Karas M., Bahr U., Fournier I., Glückmann M., and Pfenniger A. The Initial-Ion Velocity as a Marker for Different Desorption-Ionization Mechanisms in MALDI. Int. J. Mass Spectrom. 226 (2003) 239-248
26. Zhigilei L.V., Kodali P.B.S., and Garrison B.J. Molecular Dynamics Model for Laser Ablation and Desorption of Organic Solids. J. Phys. Chem. B 101 (1997) 2028-2037
27. Zhigilei L.V., Kodali P.B.S., and Garrison B.J. A Microscopic View of Laser Ablation. J. Phys. Chem. B 102 (1998) 2845-2853
28. Zhigilei L.V., and Garrison B.J. Microscopic Mechanisms of Laser Ablation of Organic Solids in the Thermal and Stress Confinement Irradiation Regimes. J. Appl. Phys. 88 (2000) 1281-1298
29. Juhasz P., Vestal M.L., and Martin S.A. On the Initial Velocity of Ions Generated by Matrix-Assisted Laser Desorption Ionization and its Effect on the Calibration of Delayed Extraction Time-of-Flight Mass Spectra. J. Am. Soc. Mass Spectrom. 8 (1997) 209-217
30. Glückmann M., and Karas M. The Initial Ion Velocity and its Dependence on Matrix, Analyte, and Preparation Method in Ultraviolet Matrix-Assisted Laser Desorption/Ionization. J. Mass Spectrom. 34 (1999) 467-477
31. McCombie G., and Knochenmuss R. Enhanced MALDI Ionization Efficiency at the Metal-Matrix Interface: Practical and Mechanistic Consequences of Sample Thickness and Preparation Method. J. Am. Soc. Mass Spectrom. 17 (2006) 737-745
32. Knochenmuss R., McCombie G., and Faderl M. Ion Yields of Thin MALDI Samples: Dependence on Matrix and Metal Substrate and Implications for Models. J. Phys. Chem. A 110 (2006) 12728-12733