Elevated levels of plasma fibrinogen in patients with pancreatic cancer: Possible role of a distant metastasis predictor

Pancreas

Volumn 38, Issue 3, 2009, Pages

  Guo, Qingqu ^a   Zhang, Bo ^a   Dong, Xin ^a   Xie, Qiuping ^a   Guo, Enqi ^a   Huang, Hai ^a   Wu, Yulian ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Distant metastasis; Pancreatic cancer; Plasma fibrinogen

Indexed keywords

CA 19-9 ANTIGEN; FIBRINOGEN; BIOLOGICAL MARKER; C REACTIVE PROTEIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BENIGN TUMOR; CANCER GROWTH; CANCER PATIENT; CANCER STAGING; CONTROLLED STUDY; CYSTADENOMA; DISTANT METASTASIS; FEMALE; FIBRINOGEN BLOOD LEVEL; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PANCREAS ADENOCARCINOMA; PANCREAS TUMOR; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION; TUMOR VOLUME; UNIVARIATE ANALYSIS; ADOLESCENT; BLOOD; METABOLISM; METASTASIS; MIDDLE AGED; NEOPLASM; PANCREAS CARCINOMA; PATHOLOGY; PREDICTION AND FORECASTING; STATISTICAL MODEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CA-19-9 ANTIGEN; CARCINOMA, PANCREATIC DUCTAL; FEMALE; FIBRINOGEN; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASMS; PANCREATIC NEOPLASMS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 65549104265     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181987d86     Document Type: Article

References (22)

1. van Gulik TM, Reeders JW, Bosma A, et al. Incidence and clinical findings of benign, inflammatory disease in patients resected for presumed pancreatic head cancer. Gastrointest Endosc. 1997;46:417-423.
2. Trifunovic J, Muzikravic L, Prvulovic M, et al. Evaluation of imaging techniques and CA 19-9 in differential diagnosis of carcinoma and other focal lesions of pancreas. Arch Oncol. 2004;12:104-108.
3. Staton CA, Brown NJ, Lewis CE. The role of fibrinogen and related fragments in tumour angiogenesis and metastasis. Expert Opin Biol Ther. 2003;3:1105-1120.
4. Palumbo JS, Talmage KE, Liu H, et al. Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency. Blood. 2003;102:2819-2827.
5. Palumbo JS, Talmage KE, Massari JV, et al. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cellYmediated elimination of tumor cells. Blood. 2005;105:178-185.
6. Jones JM, McGonigle NC, McAnespie M, et al. Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer. Lung Cancer. 2006;53:97-101.
7. Yamashita H, Kitayama J, Nagawa H. Hyperfibrinogenemia is a useful predictor for lymphatic metastasis in human gastric cancer. Jpn J Clin Oncol. 2005;35:595-600.
8. Lee JH, Ryu KW, Kim S, et al. Preoperative plasma fibrinogen levels in gastric cancer patients correlate with extent of tumor. Hepatogastroenterology. 2004;51:1860-1863.
9. Wayman J, O'Hanlon D, Hayes N, et al. Fibrinogen levels correlate with stage of disease in patients with oesophageal cancer. Br J Surg. 1997;84:185-188.
10. Yamashita H, Kitayama J, Kanno N, et al. Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer. BMC Cancer. 2006;6:147.
11. Preston K, Slater C, McMillan DC, et al. Fibrinogen synthesis is elevated in fasting cancer patients with an acute phase response. J Nutr. 1998;128:1355-1360.
12. Sobin LH, Wittekind C. UICC: TNM Classification of Malignant Tumours. 6th ed. London, England: John Wiley & Sons; 2002.
13. Bloomston M, Zhou JX, Rosemurgy AS, et al. Fibrinogen γ overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples. Cancer Res. 2006;66:2592-2599.
14. Palumbo JS, Kombrinck KW, Drew AF, et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood. 2000;96:3302-3309.
15. Simpson-haidaris PJ, Rybarczyk B. Tumors and fibrinogen: the role of fibrinogen as an extracellular matrix protein. Ann NY Acad Sci. 2001;936:406-425.
16. Shoji M, Hancock WW, Abe K, et al. Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. Am J Pathol. 1998;152:399-411.
17. Anastassiou G, Duensing S, Steinhoff G, et al. In vivo distribution of integrins in renal cell carcinoma: integrin-phenotype alteration in different degrees of tumor differentiation and VLA-2 involvement in tumor metastasis. Cancer Biother. 1995;10:287-292.
18. Pignatelli M, Bodmer WF. Integrin-receptorYmediated differentiation and growth inhibition are enhanced by transforming growth factor-beta in colorectal tumour cells grown in collagen gel. Int J Cancer. 1989;44:518-523.
19. Tachibana I, Mori M, Tanio Y, et al. A 100-kDa protein tyrosine phosphorylation is concurrent with β1 integrin - mediated morphological differentiation in neuroblastoma and small cell lung cancer cells. Exp Cell Res. 1996;227:230-239.
20. Dvorak HF. Thrombosis and cancer. Hum Pathol. 1987;18:275-284.
21. Yamaguchi T, Yamamoto Y, Yokota S, et al. Involvement of interleukin-6 in the elevation of plasma fibrinogen levels in lung cancer patients. Jpn J Clin Oncol. 1998;28:740-744.
22. Yamaguchi T, Kimura H, Yokota S, et al. Effect of IL-6 elevation in malignant pleural effusion on hyperfibrinogenemia in lung cancer patients. Jpn J Clin Oncol. 2000;30:53-58.