A pilot study of nicotine delivery to smokers from a metered-dose inhaler

Nicotine and Tobacco Research

Volumn 11, Issue 4, 2009, Pages 342-347

  Caldwell, Brent ^a   Dickson, Stuart ^b   Burgess, Carl ^a   Siebers, Robert ^a   Mala, Sima ^a   Parkes, Adrienne ^a   Crane, Julian ^a  

^a UNIVERSITY OF OTAGO WELLINGTON   (New Zealand)

^b INSTITUTE OF ENVIRONMENTAL SCIENCE AND RESEARCH   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; CIGARETTE SMOKING; CLINICAL ARTICLE; CLINICAL TRIAL; COUGHING; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG WITHDRAWAL; FEMALE; HEART RATE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; METERED DOSE INHALER; PATIENT SATISFACTION; PILOT STUDY; PRIORITY JOURNAL; SMOKING CESSATION; TOBACCO DEPENDENCE;

ADULT; BLOOD PRESSURE; FEMALE; HEART RATE; HUMANS; MALE; METERED DOSE INHALERS; MIDDLE AGED; NICOTINE; NICOTINIC AGONISTS; PATIENT SATISFACTION; PILOT PROJECTS; SMOKING CESSATION; TOBACCO USE DISORDER; YOUNG ADULT;

EID: 65549098830     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/ntp027     Document Type: Article

References (25)

1. Andrus, P. G., Rhem, R., Rosenfeld, J., & Dolovich, M. B. (1999). Nicotine microaerosol inhaler. Canadian Respiratory Journal, 6, 509-512.
2. Cox, L. S., Tiffany, S. T., & Christen, A. G. (2001). Evaluation of the brief Questionnaire of Smoking Urges (QSU-brief) in laboratory and clinical settings. Nicotine & Tobacco Research, 3, 7-16.
3. Etter, J.-F., & Stapleton, J. A. (2006). Nicotine replacement therapy for long-term smoking cessation: A meta-analysis. Tobacco Control, 15 280-285.
4. Fowles, J., Phillips, D., & Kaiserman, M. (2003). Chemical composition of tobacco and cigarette smoke in two brands of New Zealand cigarettes. Wellington, New Zealand: Ministry of Health.
5. Henningfield, J. E., & Keenan, R. M. (1993). Nicotine delivery kinetics and abuse liability. Journal of Consulting & Clinical Psychology, 61 743-750.
6. Herxheimer, A., Griffiths, R. L., Hamilton, B., & Wake, M. (1967). Circulatory effects of nicotine aerosol inhalations and cigarette smoking in man. Lancet, 2, 754-755.
7. Hinds, W. C. (1978). Size characteristics of cigarette smoke. American Industrial Hygiene Association Journal, 39, 48-54.
8. Hukkanen, J., Jacob, P. III., & Benowitz, N. L. (2005). Metabolism and disposition kinetics of nicotine. Pharmacological Reviews, 57, 79-115.
9. Juliano, L. M., & Brandon, T. H. (2004). Smokers' expectancies for nicotine replacement therapy vs. cigarettes. Nicotine & Tobacco Research, 6, 569-574.
10. Leach, C. L., Davidson, P. J., & Boudreau, R. J. (1998). Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. European Respiratory Journal, 12 1346-1353.
11. Lunell, E., Bergstrom, M., Antoni, G., Langstrom, B., & Nordberg, A. (1996). Nicotine deposition and body distribution from a nicotine inhaler and a cigarette studied with positron emission tomography. Clinical Pharmacology and Therapeutics, 59, 593-594.
12. Lunell, E., Molander, L., Ekberg, K., & Wahren, J. (2000). Site of nicotine absorption from a vapour inhaler - Comparison with cigarette smoking. European Journal of Clinical Pharmacology, 55, 737-741.
13. Molander, L., Lunell, E., Andersson, S. B., & Kuylenstierna, F. (1996). Dose released and absolute bioavailability of nicotine from a nicotine vapor inhaler. Clinical Pharmacology and Therapeutics, 59, 394-400.
14. Pankow, J. F. (2001). A consideration of the role of gas/particle partitioning in the deposition of nicotine and other tobacco smoke compounds in the respiratory tract. Chemical Research in Toxicology, 14, 1465-1481.
15. Rose, J. E. (2006). Nicotine and nonnicotine factors in cigarette addiction. Psychopharmacology, 184, 274-285.
16. Russell, M. A. H. (1988). Nicotine replacement: The role of nicotine blood levels, their rate of change, and nicotine tolerance. In O. F. Pomerleau and C. S. Pomerleau (Eds.), Nicotine replacement: A critical evaluation (pp. 63-94), New York: Liss.
17. Schneider, N. G. (1992). Nicotine therapy in smoking cessation: Pharmacokinetic considerations. Clinical Pharmacokinetics, 23, 169-172.
18. Schneider, N. G., Koury, M. A., Franzon, M., & Lunell, E. (2006). Preferences among four combination nicotine treatments. Psychopharmacology, 187, 476-485.
19. Schneider, N. G., Olmstead, R. E., Franzon, M. A., & Lunell, E. (2001). The nicotine inhaler: Clinical pharmacokinetics and comparison with other nicotine treatments. Clinical Pharmacokinetics, 40, 661-684.
20. Shin, H.-S., Kim, J.-G., Shin, Y.-J., & Jee, S. H. (2002). Sensitive and simple method for the determination of nicotine and cotinine in human urine, plasma and saliva by gas chromatographymass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences, 769, 177-183.
21. Silagy, C., Lancaster, T., Stead, L., Mant, D., & Fowler, G. (2004). Nicotine replacement therapy for smoking cessation. Cochrane Database of Systematic Reviews, 3.
22. Tonnesen, P., Norregaard, J., Mikkelsen, K., Jorgensen, S., & Nilsson, F. (1993). A double-blind trial of a nicotine inhaler for smoking cessation. Journal of the American Medical Association, 269, 1268-1271.
23. Wayne, G. F., Connolly, G. N., & Henningfield, J. E. (2004). Assessing internal tobacco industry knowledge of the neurobiology of tobacco dependence. Nicotine & Tobacco Research, 6, 927-940.
24. West, R., Hajek, P., Foulds, J., Nilsson, F., May, S., & Meadows, A. (2000). A comparison of the abuse liability and dependence potential of nicotine patch, gum, spray and inhaler. Psychopharmacology, 149, 198-202.
25. Westman, E., Levin, E., & Rose, J. (1992). Smoking while wearing the nicotine patch: Is smoking satisfying or harmful? Clinical Research, 40, 871A.