Cytokine concentrations are not predictive of bacteremia in febrile neutropenic patients

Medical Oncology

Volumn 26, Issue 1, 2009, Pages 55-61

  Buyukberber, Nuray ^a,b   Buyukberber, Süleyman ^c   Sevinc, Alper ^d   Camci, Celalettin ^d  

^a Refik Saydam Hygiene Center   (Turkey)

^b Merkez Laboratuar Şefliǧi ^*  (Turkey)

^c GAZI UNIVERSITY   (Turkey)

^d GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

Cancer; CRP; Cytokines; Febrile neutropenia; IL 1 ; IL 6; IL 8; SIL 2R; TNF

Indexed keywords

ANTINEOPLASTIC AGENT; C REACTIVE PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SOLUBLE INTERLEUKIN 2 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 2 RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; ARTICLE; BACTEREMIA; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FEBRILE NEUTROPENIA; FEMALE; HUMAN; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MALE; MICROBIOLOGICAL EXAMINATION; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STOMACH CANCER; AGED; BLOOD; CANDIDIASIS; FEVER; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; NEUTROPENIA; PATHOPHYSIOLOGY;

ADULT; AGED; BACTEREMIA; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CANDIDIASIS; CYTOKINES; FEMALE; FEVER; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; NEUTROPENIA; RECEPTORS, INTERLEUKIN-2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 65549096926     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12032-008-9081-z     Document Type: Article

References (38)

1. JA Talcott A Whalen J Clark PP Rieker R Finberg 1994 Home antibiotic therapy for low-risk cancer patients with fever and neutropenia: a pilot study of 30 patients based on a validated prediction rule J Clin Oncol 12 107 14
2. IA Malik WA Khan M Karim Z Aziz MA Khan 1995 Feasibility of outpatient management of fever in cancer patients with low-risk neutropenia: results of a prospective randomized trial Am J Med 98 224 31 10.1016/S0002-9343(99)80367-2
3. MM Mustafa VM Aquino A Pappo I Tkaczewski GR Buchanan 1996 A pilot study of outpatient management of febrile neutropenic children with cancer at low risk of bacteremia J Pediatr 128 847 9 10.1016/S0022-3476(96)70339-6 (Pubitemid 26181384)
4. CA Mullen D Petropoulos WM Roberts M Rytting T Zipf KW Chan 1999 Outpatient treatment of fever and neutropenia for low risk pediatric cancer patients Cancer 86 126 34 10.1002/(SICI)1097-0142(19990701)86:1 ≥ 126::AID-CNCR18 ≥ 3.0.CO;2-1
5. JA Talcott 2000 Out-patient management of febrile neutropenia Int J Antimicrob Agents 16 169 71 10.1016/S0924-8579(00)00235-1
6. JA Talcott R Finberg RJ Mayer L Goldman 1988 The medical course of cancer patients with fever and neutropenia. Clinical identification of a low-risk subgroup at presentation Arch Intern Med 148 2561 8 10.1001/archinte.148.12.2561 (Pubitemid 19048173)
7. JA Talcott RD Siegel R Finberg L Goldman 1992 Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule J Clin Oncol 10 316 22
8. RJ Klaassen TR Goodman B Pham JJ Doyle 2000 'Low-risk' prediction rule for pediatric oncology patients presenting with fever and neutropenia J Clin Oncol 18 1012 9
9. GP Bodey M Buckley YS Sathe M Paesmans 2000 Risk factors assessment in febrile neutropenia Int J Antimicrob Agents 16 107 11 10.1016/S0924-8579(00) 00241-7
10. J Klastersky M Paesmans EB Rubenstein M Boyer L Elting R Feld 2000 The Multinational Association for supportive care in cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients J Clin Oncol 18 3038 51
11. WV Kern 2006 Risk assessment and treatment of low-risk patients with febrile neutropenia Clin Infect Dis 42 533 40 10.1086/499352 (Pubitemid 43202527)
12. T Lehrnbecher D Venzon M de Haas S Chanock J Kuhl 1999 Assessment of measuring circulating levels of interleukin-6, interleukin-8, C-reactive protein, soluble Fc gamma receptor type III and mannose-binding protein in febrile children with cancer and neutropenia Clin Infect Dis 29 414 9 10.1086/520224
13. A Waage D Remick S Steinshamn L Deforge J Lamvik 1994 Interleukin 8 in serum in granulocytopenic patients with infections Br J Haematol 86 36 40 10.1111/j.1365-2141.1994.tb03249.x
14. JL Herrmann H Blanchard P Brunengo PH Lagrange 1994 TNF alpha, IL-1 beta and IL-6 plasma levels in neutropenic patients after onset of fever and correlation with the C-reactive protein (CRP) kinetic values Infection 22 309 15 10.1007/BF01715533 (Pubitemid 24316414)
15. P Engervall M Granstrom B Andersson M Bjorkholm 1995 Monitoring of endotoxin, interleukin-6 and C-reactive protein serum concentrations in neutropenic patients with fever Eur J Haematol 54 226 34
16. P Engervall B Andersson M Björkholm 1995 Clinical significance of serum cytokine patterns during start of fever in patients with neutropenia Br J Haematol 91 838 45 10.1111/j.1365-2141.1995.tb05398.x
17. H Pechumer M Wilhelm HW Ziegler-Heitbrock 1995 Interleukin-6 levels in febrile children during maximal aplasia after bone marrow transplantation are similar to those in children with normal hematopoiesis Ann Hematol 70 309 12 10.1007/BF01696617
18. H Ostermann M Rothenburger RM Mesters LJ van de J Kienast 1994 Cytokine response to infection in patients with acute myelogenous leukaemia following intensive chemotherapy Br J Haematol 88 332 7 10.1111/j.1365-2141.1994.tb05027.x
19. ES de Bont E Vellenga JC Swaanenburg V Fidler PJ Visser-van Brummen WA Kamps 1999 Plasma IL-8 and IL-6 levels can be used to define a group with low risk of septicaemia among cancer patients with fever and neutropenia Br J Haematol 107 375 80 10.1046/j.1365-2141.1999.01707.x (Pubitemid 29530226)
20. GR Stryjewski ES Nylen MJ Bell RH Snider KL Becker A Wu C Lawlor H Dalton 2005 Interleukin-6, interleukin-8, and a rapid and sensitive assay for calcitonin precursors for the determination of bacterial sepsis in febrile neutropenic children Pediatr Crit Care Med 6 129 35 10.1097/01.PCC.0000149317. 15274.48 (Pubitemid 40724303)
21. A Engel E Mack P Kern WV Kern 1998 An analysis of interleukin-8, interleukin-6 and C-reactive protein serum concentrations to predict fever, gram-negative bacteremia and complicated infection in neutropenic cancer patients Infection 26 213 21
22. G Fleischhack I Kambeck D Cipic C Hasan U Bode 2000 Procalcitonin in paediatric cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II Br J Haematol 111 1093 102 10.1046/j.1365-2141.2000.02458.x (Pubitemid 32104921)
23. WV Kern M Heiss G Steinbach 2001 Prediction of Gram-negative bacteremia in patients with cancer and febrile neutropenia by means of Interleukin-8 levels in serum: targeting empirical monotherapy versus combination therapy Clin Infect Dis 32 832 5 10.1086/319207 (Pubitemid 32221947)
24. J Abrahamsson M Pahlman L Mellander 1997 Interleukin 6, but not tumour necrosis factor-alpha, is a good predictor of severe infection in febrile neutropenic and non-neutropenic children with malignancy Acta Paediatr 86 1059 64 10.1111/j.1651-2227.1997.tb14807.x
25. D Heney IJ Lewis SW Evans R Banks CC Bailey JT Whicher 1992 Interleukin-6 and its relationship to C-reactive protein and fever in children with febrile neutropenia J Infect Dis 165 886 90
26. A Engel WV Kern G Mürdter P Kern 1994 Kinetics and correlation with body temperature of circulating interleukin-6, interleukin-8, tumour necrosis factor alpha and interleukin-1 beta in patients with fever and neutropenia Infection 2 160 3 10.1007/BF01716695 (Pubitemid 24186371)
27. M von Lilienfeld-Toal MP Dietrich A Glasmacher L Lehmann P Breig C Hahn IG Schmidt-Wolf G Marklein S Schroeder F Stuber 2004 Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein Eur J Clin Microbiol Infect Dis 23 539 44 10.1007/s10096-004-1156-y
28. PH Mackie RA Crockson J Stuart 1979 C-reactive protein for rapid diagnosis of infection in leukaemia J Clin Pathol 32 1253 6 10.1136/jcp. 32.12.1253
29. JA Katz MM Mustafa RO Bash JV Cash GR Buchanan 1992 Value of C-reactive protein determination in the initial diagnostic evaluation of the febrile, neutropenic child with cancer Pediatr Infect Dis 11 708 12
30. FA Manian 1995 A prospective study of daily measurement of C-reactive protein in serum of adults with neutropenia Clin Infect Dis 21 114 21
31. A Lindemann I Tamm K Tanodi R Mertelsmann 1995 Interleukin-8 serum levels for early detection of infections episodes in neutropenic patients J Infect Dis 172 610 3
32. H Schonbohn M Schuler K Kolbe C Peschel C Huber W Bemb WE Aulitzky 1995 Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-R A during febrile neutropenia: results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia Ann Hematol 71 161 8 10.1007/BF01910312
33. A Engel G Steinbach P Kern WV Kern 1999 Diagnostic value of procalcitonin serum levels in neutropenic patients with fever: comparison with interleukin-8 Scand J Infect Dis 31 185 9 10.1080/003655499750006254 (Pubitemid 29355529)
34. A Engel SA Knoll P Kern WV Kern 2005 Interleukin-8 serum levels at fever onset in patients with neutropenia predict early medical complications Infection 33 380 2 10.1007/s15010-005-5068-2 (Pubitemid 41552018)
35. L Persson P Engervall A Magnuson T Vikerfors B Söderquist LO Hansson U Tidefelt 2004 Use of inflammatory markers for early detection of bacteraemia in patients with febrile neutropenia Scand J Infect Dis 36 365 71 10.1080/00365540410020217 (Pubitemid 38967694)
36. N Erten S Genc SK Besisik B Saka MA Karan C Tascioglu 2004 The predictive and diagnostic values of procalcitonin and C-reactive protein for clinical outcome in febrile neutropenic patients J Chin Med Assoc 67 217 21
37. L Persson B Söderquist P Engervall T Vikerfors LO Hansson U Tidefelt 2005 Assessment of systemic inflammation markers to differentiate a stable from a deteriorating clinical course in patients with febrile neutropenia Eur J Haematol 74 297 303 10.1111/j.1600-0609.2004.00387.x (Pubitemid 40461149)
38. WT Hughes D Armstrong GP Bodey EJ Bow AE Brown T Calandra R Feld PA Pizzo KV Rolston JL Shenep LS Young 2002 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer Clin Infect Dis 34 730 51 10.1086/339215 (Pubitemid 34194843)