Convenient synthesis of 1,3-substituted-6-phenylpiperazin-2-ones

Tetrahedron Letters

Volumn 50, Issue 27, 2009, Pages 3817-3819

  Gallicchio, Steven N ^a   Bell, Ian M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOPHENONE DERIVATIVE; ESTER DERIVATIVE; PIPERAZINE DERIVATIVE;

ALKYLATION; AMINATION; ARTICLE; CYCLIZATION; ONE POT SYNTHESIS; SUBSTITUTION REACTION;

EID: 65549090022     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.04.036     Document Type: Article

References (11)

1. Park Choo H.-Y. Bioorg. Med. Chem. Lett. 9 (1999) 2727
2. Chambers M.S., and Street L.J. J. Med. Chem. 42 (1999) 691
3. Giannangeli M. J. Med. Chem. 42 (1999) 336
4. Logan M.E., Goswami R., Tomczuk B.E., and Venepalli B.R. Annu. Rep. Med. Chem. 26 (1989) 43
5. Kendrick D.A., Ryder H., Semple G., and Szelke M. Bioorg. Med. Chem. Lett. 2 (1992) 9
6. Dinsmore C.J., and Beshore D.C. Org. Prep. Proced. Int. 34 (2002) 367
7. Hulme C., Peng J., Louridas B., Menard P., Krolikowski P., and Kumar N.V. Tetrahedron Lett. 39 (1998) 8047
8. Kennedy A.L., Fryer A.M., and Josey J.A. Organic Lett. 4 (2002) 1167
9. Hulme C., and Gore V. Curr. Med. Chem. 10 (2003) 51
10. Nixey T., Kelly M., and Hulme C. Tetrahedron Lett. 41 (2000) 8729
11. Chiral HPLC conditions-column: Chiracel OJ; eluent: EtOH; <1% of other diastereomer detected.