Structural interaction between drug - DNA and protein - A novel approach for bioinformatics in medicine

Biomedical Research

Volumn 20, Issue 1, 2009, Pages 28-34

  Saxena, Ajit K ^a   Singh, Divja ^a   Singh, Gajendra ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Dihydrofolate reductase; DNA; Methotrexate

Indexed keywords

DIHYDROFOLATE REDUCTASE; DNA; METHOTREXATE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; BIOINFORMATICS; COMPUTER MODEL; COMPUTER PROGRAM; DRUG DNA INTERACTION; DRUG STRUCTURE; MUTATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT;

EID: 65549087013     PISSN: 0970938X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993, 362: 709-715.
2. Controlling occupational exposure to hazardous drugs (OSHA Work-Practice Guidelines). J Health Syst Pharm 1996; 53: 1669-1685
3. Chen MJ, Shimada T, Moulton AD, Cline A, Humphries RK, Maizel J, Nienhuis AW. The functional human dihydrofolate reductase gene. J Biol Chem. 1984; 259: 3933-3943.
4. Friedberg EC. DNA damage and repair. Nature 2003, 421: 436-440.
5. Jordan RL, Wilson JG, Schumacher HJ. Embryo toxicity of folate antagonist methotrexate in rat and rabbits. Teratology. 1977; 15: 73-79.
6. Saxena A K, Dhungel S, Bhattacharya S, Srivastava AK. Effect of chronic low dose of methotrexate on cellular proliferation during spermatogenesis in rat. Arch Andol. 2004; 50: 33-35.
7. West SG. Methotrexate hepatotoxicity. Rheum Dis Clin North Am. 1997; 23: 883-915
8. Thomas LL, Mertens MJ, von dem Borne AE, van Boxtel CJ, Veenhof CH, Veies EP. Clinical management of cytotoxic drug overdose. Med Toxicol Adverse Drug Exp 1988; 3: 253-263
9. Masters JN, Attardi G. The nucleotide sequence of the c DNA coding for the human dihydrofolate reductase. Gene. 1983; 21: 59-63.
10. Davies JF, Delcamp TJ, Prendergast NJ, Ashford VA, Freisheim JH, J. Kraut J. Crystal structures of recombinant human Dihydrofolate Reductase complexed with folate and Methotrexate. Nature 1990; 29: 779-784.
11. Davies JF II, Delcamp TJ, Prendergast NJ, Ashford VA, Freisheim JH, Kraut J. Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. Biochemistry. 1990; 9: 29-40.