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Volumn 11, Issue 1, 2009, Pages 30-38

Risk factors for gastrointestinal adverse events in HIV treated and untreated patients

Author keywords

Adverse events; Antiretrovirals; Boosted PI; Diarrhea; Gastrointestinal; HIV; Nausea; Toxicity; Vomiting

Indexed keywords

ABACAVIR; AMPRENAVIR PHOSPHATE; ANTIRETROVIRUS AGENT; ATAZANAVIR PLUS RITONAVIR; DARUNAVIR PLUS RITONAVIR; DIDANOSINE; EFAVIRENZ; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; LAMIVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; NUCLEOSIDE ANALOG; PLACEBO; PROTEINASE INHIBITOR; RALTEGRAVIR; RITONAVIR; RITONAVIR PLUS SAQUINAVIR; RITONAVIR PLUS TIPRANAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR; ZIDOVUDINE; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; PEPTIDE FRAGMENT; PYRIDAZINE DERIVATIVE;

EID: 65549084011     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (73)

References (47)
  • 1
    • 3042852414 scopus 로고    scopus 로고
    • Symptoms and sites of pain experienced by AIDS patients
    • Norval D. Symptoms and sites of pain experienced by AIDS patients. S Afr Med J. 2004;94:450-4.
    • (2004) S Afr Med J , vol.94 , pp. 450-454
    • Norval, D.1
  • 2
    • 33644821632 scopus 로고    scopus 로고
    • Gastrointestinal infections in immunocompromised hosts
    • Thom K, Forrest G. Gastrointestinal infections in immunocompromised hosts. Curr Opin Gastroenterol. 2006;22:18-23.
    • (2006) Curr Opin Gastroenterol , vol.22 , pp. 18-23
    • Thom, K.1    Forrest, G.2
  • 3
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley J, Price D, Schacker T, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006; 12:1365-71.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.1    Price, D.2    Schacker, T.3
  • 4
    • 0027440890 scopus 로고
    • Adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interactions
    • Bernet M, Brassart D, Neeser J, Servin A. Adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interactions. Appl Environ Microbiol. 1993;59: 4121-8.
    • (1993) Appl Environ Microbiol , vol.59 , pp. 4121-4128
    • Bernet, M.1    Brassart, D.2    Neeser, J.3    Servin, A.4
  • 5
    • 33947169259 scopus 로고    scopus 로고
    • Probiotics and prebiotics: Effects on diarrhea
    • De Vrese M, Marteau P. Probiotics and prebiotics: effects on diarrhea. J Nutr. 2007;137:803-11S.
    • (2007) J Nutr , vol.137
    • De Vrese, M.1    Marteau, P.2
  • 6
    • 0028050316 scopus 로고
    • Feeding of bifidobacterium bifidum and Streptococcs thermophilus to infants in hospital for prevention of diarrhea and shedding of rotavirus
    • Saavedra J, Bauman N, Oung I, Perman J, Yolken R. Feeding of bifidobacterium bifidum and Streptococcs thermophilus to infants in hospital for prevention of diarrhea and shedding of rotavirus. Lancet. 1994; 344:1046-9.
    • (1994) Lancet , vol.344 , pp. 1046-1049
    • Saavedra, J.1    Bauman, N.2    Oung, I.3    Perman, J.4    Yolken, R.5
  • 7
    • 27944453927 scopus 로고    scopus 로고
    • Safety of enfuvirtide in combination with an optimized background of antiretrovirals in treatment-experienced HIV-1-infected adults over 48 weeks
    • Trottier B, Walmsley S, Reynes J, et al. Safety of enfuvirtide in combination with an optimized background of antiretrovirals in treatment-experienced HIV-1-infected adults over 48 weeks. J Acquir Immune Defic Syndr. 2005;40:413-21.
    • (2005) J Acquir Immune Defic Syndr , vol.40 , pp. 413-421
    • Trottier, B.1    Walmsley, S.2    Reynes, J.3
  • 8
    • 43749121302 scopus 로고    scopus 로고
    • DUET-1: Week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 612 treatment-experienced HIV-1-infected patients
    • Boston, USA [abstract 790
    • Haubrich R, Cahn P, Grinsztejn B, et al. DUET-1: Week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 612 treatment-experienced HIV-1-infected patients. 15th CROI, February 2008, Boston, USA [abstract 790].
    • (2008) 15th CROI, February
    • Haubrich, R.1    Cahn, P.2    Grinsztejn, B.3
  • 9
    • 43749103048 scopus 로고    scopus 로고
    • DUET-2: Week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 591 treatmentexperienced HIV-1-infected patients
    • Boston, USA [abstract 791
    • Johnson M, Campbell T, Clotet B, Katlama C, Lazzarin A, Towner W. DUET-2: Week-48 results of a phase III randomized double-blind trial to evaluate the efficacy and safety of TMC125 vs placebo in 591 treatmentexperienced HIV-1-infected patients. 15th CROI, February 2008, Boston, USA [abstract 791].
    • (2008) 15th CROI, February
    • Johnson, M.1    Campbell, T.2    Clotet, B.3    Katlama, C.4    Lazzarin, A.5    Towner, W.6
  • 10
    • 0345256371 scopus 로고    scopus 로고
    • Patterns and correlates of discontinuation of the initial HAART regimen in an urban outpatient cohort
    • O'Brien M, Clark R, Besch C, Myers L, Kissinger P. Patterns and correlates of discontinuation of the initial HAART regimen in an urban outpatient cohort. J Acquir Immune Defic Syndr. 2003;34:407-14.
    • (2003) J Acquir Immune Defic Syndr , vol.34 , pp. 407-414
    • O'Brien, M.1    Clark, R.2    Besch, C.3    Myers, L.4    Kissinger, P.5
  • 11
    • 67649580637 scopus 로고    scopus 로고
    • HIV-associated diarrhea in the era of HAART: Still prevalent after all these years
    • May, USA [abstract S1065 poster
    • Siddiqui U, et al. HIV-associated diarrhea in the era of HAART: Still prevalent after all these years. Digestive Disease Week, May 2003, USA [abstract S1065 (poster)].
    • (2003) Digestive Disease Week
    • Siddiqui, U.1
  • 12
    • 67649601153 scopus 로고    scopus 로고
    • Division of AIDS table for grading the severity of adult and paediatric adverse events. DAIDS 2007; http://rcc.tech.res.com/DAIDS%20RCC%20Forms/ TB_ToxicityTables_DAIDS_AE_GradingTable_Final-Dec2004.pdf (accessed March 2007).
    • Division of AIDS table for grading the severity of adult and paediatric adverse events. DAIDS 2007; http://rcc.tech.res.com/DAIDS%20RCC%20Forms/ TB_ToxicityTables_DAIDS_AE_GradingTable_Final-Dec2004.pdf (accessed March 2007).
  • 14
    • 3943101413 scopus 로고    scopus 로고
    • Once-daily versus twice-daily lamivudine, in combination with zidovudine and efavirenz, for the treatment of antiretroviral-naive adults with HIV Infection: A randomized equivalence trial
    • De Jesus E, McCarty D, Farthing C, et al. Once-daily versus twice-daily lamivudine, in combination with zidovudine and efavirenz, for the treatment of antiretroviral-naive adults with HIV Infection: A randomized equivalence trial. Clin Infect Dis. 2004;39:411-8.
    • (2004) Clin Infect Dis , vol.39 , pp. 411-418
    • De Jesus, E.1    McCarty, D.2    Farthing, C.3
  • 15
    • 20844462378 scopus 로고    scopus 로고
    • Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral naive HIV infected adults
    • DeJesus E, Herrera G, Teofilo E, et al. Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral naive HIV infected adults. Clin Infect Dis. 2004;39:1038-46.
    • (2004) Clin Infect Dis , vol.39 , pp. 1038-1046
    • DeJesus, E.1    Herrera, G.2    Teofilo, E.3
  • 16
    • 30944468562 scopus 로고    scopus 로고
    • Tenofovir DF, emtricitabine and efavirenz vs zidovudine, lamivudine and efavirenz for HIV
    • Gallant J, DeJesus E, Arribas J, et al. Tenofovir DF, emtricitabine and efavirenz vs zidovudine, lamivudine and efavirenz for HIV. N Engl J Med. 2006;354:251-60.
    • (2006) N Engl J Med , vol.354 , pp. 251-260
    • Gallant, J.1    DeJesus, E.2    Arribas, J.3
  • 17
    • 43149106498 scopus 로고    scopus 로고
    • Fosamprenavir or atazanavir with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48 week results of ALERT
    • Smith K, Weinberg W, DeJesus E, et al. Fosamprenavir or atazanavir with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48 week results of ALERT. AIDS Res Ther. 2008;5:5.
    • (2008) AIDS Res Ther , vol.5 , pp. 5
    • Smith, K.1    Weinberg, W.2    DeJesus, E.3
  • 18
    • 0026490091 scopus 로고    scopus 로고
    • Koch M, Volberding P, Lagakos S, Booth D, Pettinelli C, Myers M. Toxic effects of zidovudine in asymptomatic HIV-infected individuals with CD4+ cell counts of 0.5 × 109/L or less. Arch Intern Med. 1992; 152: 2286-92.
    • Koch M, Volberding P, Lagakos S, Booth D, Pettinelli C, Myers M. Toxic effects of zidovudine in asymptomatic HIV-infected individuals with CD4+ cell counts of 0.5 × 109/L or less. Arch Intern Med. 1992; 152: 2286-92.
  • 19
    • 0037076711 scopus 로고    scopus 로고
    • Tenofovir DR in antiretroviral experienced patients: Results from a 48-week, randomized, double-blind study
    • Schooley R, Ruane P, Myers R, et al. Tenofovir DR in antiretroviral experienced patients: results from a 48-week, randomized, double-blind study. AIDS. 2002;16:1257-63.
    • (2002) AIDS , vol.16 , pp. 1257-1263
    • Schooley, R.1    Ruane, P.2    Myers, R.3
  • 20
    • 0141609130 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate in nucleoside resistant HIV-1 infection
    • Squires K, Pozniak A, Pierone G, et al. Tenofovir disoproxil fumarate in nucleoside resistant HIV-1 infection. Ann Intern Med. 2003;139: 313-20.
    • (2003) Ann Intern Med , vol.139 , pp. 313-320
    • Squires, K.1    Pozniak, A.2    Pierone, G.3
  • 21
    • 67649610799 scopus 로고    scopus 로고
    • Efficacy and safety of abacavir/ lamivudine compared to tenofovir/emtricitabine in combination with one-daily lopinavir-ritonavir through 48 weeks in the HEAT Study
    • Boston, USA [abstract 774
    • Smith K, Fine D, Patel P, et al. Efficacy and safety of abacavir/ lamivudine compared to tenofovir/emtricitabine in combination with one-daily lopinavir-ritonavir through 48 weeks in the HEAT Study. 15th CROI, February 2008, Boston, USA [abstract 774].
    • (2008) 15th CROI, February
    • Smith, K.1    Fine, D.2    Patel, P.3
  • 22
    • 3142697068 scopus 로고    scopus 로고
    • Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naive patients: A randomized trial
    • Saag M, Cahn P, Raffi F, et al. Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naive patients: a randomized trial. JAMA. 2004;292:180-9.
    • (2004) JAMA , vol.292 , pp. 180-189
    • Saag, M.1    Cahn, P.2    Raffi, F.3
  • 23
    • 0033370077 scopus 로고    scopus 로고
    • Didanosine: An updated review of its use in HIV infection
    • Perry C, Noble S. Didanosine: an updated review of its use in HIV infection. Drugs. 1999;58:1099-135.
    • (1999) Drugs , vol.58 , pp. 1099-1135
    • Perry, C.1    Noble, S.2
  • 24
    • 43549094732 scopus 로고    scopus 로고
    • Class-sparing regimens for initial treatment of HIV-1 infection
    • ACTG Study 5142 Team
    • Riddler S, Haubrich R, DiRienzo A, et al. (ACTG Study 5142 Team). Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med. 2008;358:2095-106.
    • (2008) N Engl J Med , vol.358 , pp. 2095-2106
    • Riddler, S.1    Haubrich, R.2    DiRienzo, A.3
  • 25
    • 0028806725 scopus 로고
    • A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
    • Markowitz M, Saag M, Powderly W, et al. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N Engl J Med. 1995;23:1534-9.
    • (1995) N Engl J Med , vol.23 , pp. 1534-1539
    • Markowitz, M.1    Saag, M.2    Powderly, W.3
  • 26
    • 0028846165 scopus 로고
    • A short-term study of the safety, pharmacokinetics and efficacy of ritonavir, an inhibitor of HIV protease
    • Danner S, Carr A, Leonard J, et al. A short-term study of the safety, pharmacokinetics and efficacy of ritonavir, an inhibitor of HIV protease. N Engl J Med. 1995;333:1528-34.
    • (1995) N Engl J Med , vol.333 , pp. 1528-1534
    • Danner, S.1    Carr, A.2    Leonard, J.3
  • 27
    • 0037182766 scopus 로고    scopus 로고
    • Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
    • Walmsley S, Bernstein B, King M, et al. Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med. 2002; 346:2039-46.
    • (2002) N Engl J Med , vol.346 , pp. 2039-2046
    • Walmsley, S.1    Bernstein, B.2    King, M.3
  • 28
    • 20744442305 scopus 로고    scopus 로고
    • Predictive factors of lopinavir/ritonavir discontinuation for drug-related toxicity: Results from a cohort of 416 multi-experienced HIV-infected individuals
    • Bogovanni M, Cicconi P, Landonio S, et al. Predictive factors of lopinavir/ritonavir discontinuation for drug-related toxicity: results from a cohort of 416 multi-experienced HIV-infected individuals. Int J Antimicrob Agents. 2005;26:88-91.
    • (2005) Int J Antimicrob Agents , vol.26 , pp. 88-91
    • Bogovanni, M.1    Cicconi, P.2    Landonio, S.3
  • 29
    • 33748998449 scopus 로고    scopus 로고
    • A once-daily lopinavir/ ritonavir-based regimen provides noninferior antiviral activity compared with a twice-daily regimen
    • Johnson M, Gathe J, Pocdzamczer D, et al. A once-daily lopinavir/ ritonavir-based regimen provides noninferior antiviral activity compared with a twice-daily regimen. J Acquir Immune Defic Syndr. 2006;43:153-60.
    • (2006) J Acquir Immune Defic Syndr , vol.43 , pp. 153-160
    • Johnson, M.1    Gathe, J.2    Pocdzamczer, D.3
  • 30
    • 67649574365 scopus 로고    scopus 로고
    • Study M05-730 primary efficacy results at week 48: Phase 3, randomized, open-label study of lopinavir-ritonavir (LPV/r) tablets once-daily versus twice-daily, co-administered with tenofovir (TDF) + emtricitabine (FTC) in antiretroviral naïve HIV-1 infected subjects
    • Boston, USA [abstract 775
    • Gathe J, daSilva B, Loufty M, et al. Study M05-730 primary efficacy results at week 48: Phase 3, randomized, open-label study of lopinavir-ritonavir (LPV/r) tablets once-daily versus twice-daily, co-administered with tenofovir (TDF) + emtricitabine (FTC) in antiretroviral naïve HIV-1 infected subjects. 15th CROI, February 2008, Boston, USA [abstract 775].
    • (2008) 15th CROI, February
    • Gathe, J.1    daSilva, B.2    Loufty, M.3
  • 31
    • 34147176581 scopus 로고    scopus 로고
    • The tablet formulation of lopinavir/ ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect
    • Klein C, Chiu Y, Awni W, et al. The tablet formulation of lopinavir/ ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect. J Acquir Immune Defic Syndr. 2007;44:401-10.
    • (2007) J Acquir Immune Defic Syndr , vol.44 , pp. 401-410
    • Klein, C.1    Chiu, Y.2    Awni, W.3
  • 32
    • 67649589062 scopus 로고    scopus 로고
    • Efficacy and safety of boosted once-daily atazanavir and twice-daily lopinavir regimens in treatment-naïve HIV-1 infected subjects. CASTLE: 48-week results
    • Boston, USA [presentation 37
    • Molina J, et al. Efficacy and safety of boosted once-daily atazanavir and twice-daily lopinavir regimens in treatment-naïve HIV-1 infected subjects. CASTLE: 48-week results. 15th CROI, February 2008, Boston, USA [presentation 37].
    • (2008) 15th CROI, February
    • Molina, J.1
  • 33
    • 17844387166 scopus 로고    scopus 로고
    • Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures
    • Johnson M, Grinsztejn B, Rodriguez C, et al. Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures. AIDS. 2005;19:685-94.
    • (2005) AIDS , vol.19 , pp. 685-694
    • Johnson, M.1    Grinsztejn, B.2    Rodriguez, C.3
  • 34
    • 42049118104 scopus 로고    scopus 로고
    • Once-daily ritonavir (100mg) boosting of fosamprenavir (FPV/r) or atazanavir (ATZ/r) with tenofovir (TDF)/emtricitabine (FTC) in ART-naïve HIV-infected patients: 48 week safety/efficacy results from COL103952 (ALERT)
    • Sydney, Australia [abstract WEPEB023
    • Smith K, et al. Once-daily ritonavir (100mg) boosting of fosamprenavir (FPV/r) or atazanavir (ATZ/r) with tenofovir (TDF)/emtricitabine (FTC) in ART-naïve HIV-infected patients: 48 week safety/efficacy results from COL103952 (ALERT). 4th International AIDS Conference, July 2007, Sydney, Australia [abstract WEPEB023].
    • (2007) 4th International AIDS Conference, July
    • Smith, K.1
  • 35
    • 49649092719 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir-ritonavir in treatment naive HIV-1 infected patients at Week 48
    • Ortiz R, DeJesus E, Khanlou H, et al. Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir-ritonavir in treatment naive HIV-1 infected patients at Week 48. AIDS. 2008;22:1389-97.
    • (2008) AIDS , vol.22 , pp. 1389-1397
    • Ortiz, R.1    DeJesus, E.2    Khanlou, H.3
  • 36
    • 34347329093 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomized controlled phase III trial
    • Madruga J, Berger D, McMurchie M, et al. Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomized controlled phase III trial. Lancet. 2007;370:49-58.
    • (2007) Lancet , vol.370 , pp. 49-58
    • Madruga, J.1    Berger, D.2    McMurchie, M.3
  • 38
    • 33746706779 scopus 로고    scopus 로고
    • The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: A randomised non-inferiority trial
    • Eron J, Yeni P, Gathe J, et al. The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial. Lancet. 2006;368:476-82.
    • (2006) Lancet , vol.368 , pp. 476-482
    • Eron, J.1    Yeni, P.2    Gathe, J.3
  • 39
    • 67649577077 scopus 로고    scopus 로고
    • Once-daily fosamprenavir boosted with either 100mg or 200mg of ritonavir along with abacavir/lamivudine: 48 week safety and efficacy results from COL100758
    • Madrid, Spain [abstract PS 7.01
    • Hicks C, De Jesus E, Wohl D, Liao Q, Pappa K, Lancaster T. Once-daily fosamprenavir boosted with either 100mg or 200mg of ritonavir along with abacavir/lamivudine: 48 week safety and efficacy results from COL100758. 11th European AIDS Conference, October 2007, Madrid, Spain [abstract PS 7.01].
    • (2007) 11th European AIDS Conference, October
    • Hicks, C.1    De Jesus, E.2    Wohl, D.3    Liao, Q.4    Pappa, K.5    Lancaster, T.6
  • 40
    • 67649604662 scopus 로고    scopus 로고
    • Walmsley S, Ruxrungtham K, Slim J, et al. The Gemini Study: saquinavir/r (SQV/r) vs lopinavir (LPV/r) plus emtricitabine/tenofovir (FTC/TDF) as initial therapy in HIV-1 infected patients. 11th European AIDS Conference, October 2007, Madrid, Spain [abstract PS1/4].
    • Walmsley S, Ruxrungtham K, Slim J, et al. The Gemini Study: saquinavir/r (SQV/r) vs lopinavir (LPV/r) plus emtricitabine/tenofovir (FTC/TDF) as initial therapy in HIV-1 infected patients. 11th European AIDS Conference, October 2007, Madrid, Spain [abstract PS1/4].
  • 41
    • 25444471854 scopus 로고    scopus 로고
    • A randomized trial to evaluate lopinavir/ritonavir versus saquinavir/ritonavir in HIV-1 infected patients: The MaxCmin 2 trial
    • Dragsted U, Gerstoft J, Youle M, et al. A randomized trial to evaluate lopinavir/ritonavir versus saquinavir/ritonavir in HIV-1 infected patients: the MaxCmin 2 trial. Antivir Ther. 2005;10:735-43.
    • (2005) Antivir Ther , vol.10 , pp. 735-743
    • Dragsted, U.1    Gerstoft, J.2    Youle, M.3
  • 42
    • 33746576313 scopus 로고    scopus 로고
    • Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials
    • Hicks C, Cahn P, Cooper D, et al. Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: an analysis of combined data from two randomised open-label trials. Lancet. 2006;368:466-75.
    • (2006) Lancet , vol.368 , pp. 466-475
    • Hicks, C.1    Cahn, P.2    Cooper, D.3
  • 43
    • 34047151333 scopus 로고    scopus 로고
    • Efficacy and safety of two doses of tipranavir/ ritonavir versus lopinavir/ritonavir-based therapy in antiretroviral-naive patients: Results of BI 1182.33
    • Glasgow [abstract PL13.4
    • Cooper D, et al. Efficacy and safety of two doses of tipranavir/ ritonavir versus lopinavir/ritonavir-based therapy in antiretroviral-naive patients: results of BI 1182.33. 8th International Congress on Drug Therapy in HIV Infection, October 2006, Glasgow [abstract PL13.4].
    • (2006) 8th International Congress on Drug Therapy in HIV Infection, October
    • Cooper, D.1
  • 44
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment experienced patients with multidrug resistant virus: A Phase II randomized controlled trial
    • Grinzstein B, Nguyen B, Katlama C, et al. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment experienced patients with multidrug resistant virus: a Phase II randomized controlled trial. Lancet. 2007;369:1261-9.
    • (2007) Lancet , vol.369 , pp. 1261-1269
    • Grinzstein, B.1    Nguyen, B.2    Katlama, C.3
  • 45
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Cooper D, Steigbigel R, Gatell J, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med. 2008;359: 355-65.
    • (2008) N Engl J Med , vol.359 , pp. 355-365
    • Cooper, D.1    Steigbigel, R.2    Gatell, J.3
  • 46
    • 35548983281 scopus 로고    scopus 로고
    • A multicentre, randomised, double-blind, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with Combivir (zidovudine [ZDV]/ lamivudine[3TC], for the treatment of antiretroviral naive patients infected with R5 HIV1; Week 48 results of the MERIT Study
    • Sydney, Australia [abstract WESS104
    • Saag M, Ive P, Heera J, et al. A multicentre, randomised, double-blind, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with Combivir (zidovudine [ZDV]/ lamivudine[3TC], for the treatment of antiretroviral naive patients infected with R5 HIV1; Week 48 results of the MERIT Study. 4th IAS Conference on HIV pathogenesis, treatment and prevention, July 2007, Sydney, Australia [abstract WESS104].
    • (2007) 4th IAS Conference on HIV pathogenesis, treatment and prevention, July
    • Saag, M.1    Ive, P.2    Heera, J.3
  • 47
    • 54849146700 scopus 로고    scopus 로고
    • Maraviroc for previously treated patients with R5 HIV-1 infection
    • Gulick RM, Lalezari J, Goodrich J, et al. Maraviroc for previously treated patients with R5 HIV-1 infection. N Engl J Med. 2008;359:1429-41.
    • (2008) N Engl J Med , vol.359 , pp. 1429-1441
    • Gulick, R.M.1    Lalezari, J.2    Goodrich, J.3


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