Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial

The Lancet

Volumn 373, Issue 9675, 2009, Pages 1623-1631

  Staedke, Sarah G ^a   Mwebaza, Norah ^b   Kamya, Moses R ^b   Clark, Tamara D ^c   Dorsey, Grant ^c   Rosenthal, Philip J ^c   Whitty, Christopher JM ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER; BENFLUMETOL; CHLOROQUINE; FANSIDAR;

ARTICLE; CHILD; CLINICAL TRIAL; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG COST; FEMALE; FOLLOW UP; HOME CARE; HOME DELIVERY; HOUSEHOLD; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALARIA; MALE; PARASITEMIA; PRESCHOOL CHILD; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; UGANDA; URBAN AREA;

EID: 65449182770     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(09)60328-7     Document Type: Article

References (39)

1. WHO. The Abuja declaration and the plan of action (2003), World Health Organization, Geneva
2. Breman J. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Am J Trop Med Hyg 64 (2001) 1-11
3. McCombie S.C. Treatment seeking for malaria: a review of recent research. Soc Sci Med 43 (1996) 933-945
4. WHO. Scaling up home-based management of malaria: from research to implementation (2004), World Health Organization, Geneva
5. Kilian A.H., Tindyebwa D., Gulck T., et al. Attitude of women in western Uganda towards pre-packed, unit-dosed malaria treatment for children. Trop Med Int Health 8 (2003) 431-438
6. Nsabagasani X., Nsungwa S.J., Kallander K., Peterson S., Pariyo G., and Tomson G. Home-based management of fever in rural Uganda: community perceptions and provider opinions. Malar J 6 (2007) 11
7. Nsungwa-Sabiiti J., Peterson S., Pariyo G., Ogwal-Okeng J., Petzold M.G., and Tomson G. Home-based management of fever and malaria treatment practices in Uganda. Trans R Soc Trop Med Hyg 101 (2007) 1199-1207
8. WHO. The Roll Back Malaria strategy for improving access to treatment through home management for malaria (2005), World Health Organization, Geneva WHO/HTM/MAL/2005.1101
9. Black R.E., Morris S.S., and Bryce J. Where and why are 10 million children dying every year?. Lancet 361 (2003) 2226-2234
10. Kallander K., Tomson G., Nsungwa-Sabiiti J., Senyonjo Y., Pariyo G., and Peterson S. Community referral in home management of malaria in western Uganda: a case series study. BMC Int Health Hum Rights 6 (2006) 2
11. Reyburn H., Mbatia R., Drakeley C., et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. BMJ 329 (2004) 1212
12. Talisuna A.O., Bloland P., and D'Alessandro U. History, dynamics, and public health importance of malaria parasite resistance. Clin Microbiol Rev 17 (2004) 235-254
13. Snow R.W., Eckert E., and Teklehaimanot A. Estimating the needs for artesunate-based combination therapy for malaria case-management in Africa. Trends Parasitol 19 (2003) 363-369
14. Hopkins H., Talisuna A., Whitty C.J., and Staedke S.G. Impact of home-based management of malaria on health outcomes in Africa: a systematic review of the evidence. Malar J 6 (2007) 134
15. D'Alessandro U., Talisuna A., and Boelaert M. Editorial: should artemisinin-based combination treatment be used in the home-based management of malaria?. Trop Med Int Health 10 (2005) 1-2
16. Pagnoni F., Kengeya-Kayondo J., Ridley R., et al. Artemisinin-based combination treatment in home-based management of malaria. Trop Med Int Health 10 (2005) 621-622
17. Keiser J., Utzinger J., de Castro M.C., Smith T.A., Tanner M., and Singer B.H. Urbanization in sub-saharan Africa and implication for malaria control. Am J Trop Med Hyg 71 suppl 2 (2004) 118-127
18. Davis J.C., Clark T.D., Kemble S.K., et al. Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitment. Malar J 5 (2006) 18
19. Dorsey G., Staedke S., Clark T.D., et al. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA 297 (2007) 2210-2219
20. Kemble S.K., Davis J.C., Nalugwa T., et al. Prevention and treatment strategies used for the community management of childhood fever in Kampala, Uganda. Am J Trop Med Hyg 74 (2006) 999-1007
21. Wiseman V., Conteh L., and Matovu F. Using diaries to collect data in resource-poor settings: questions on design and implementation. Health Policy Plan 20 (2005) 394-404
22. Uganda Ministry of Health. Implementation guidelines for the home based management of fever strategy. 2nd edn (2004), Ministry of Health, Uganda, Kampala
23. Uganda Ministry of Health. Management of uncomplicated malaria: a practical guide for health care workers. 3rd edn (2004), Ministry of Health, Uganda, Kampala
24. Hayes R., and Bennett S. Simple sample size calculations for cluster-randomized trials. Int J Epidemiol 28 (1999) 319-326
25. Dorsey G., Njama D., Kamya M.R., et al. Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet 360 (2002) 2031-2038
26. Clark T.D., Greenhouse B., Njama-Meya D., et al. Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis 198 (2008) 393-400
27. Roll Back Malaria Partnership. Monitoring and evaluation reference group (MERG). http://www.rbm.who.int/merg.html (accessed May 2, 2008).
28. Spencer H.C., Kaseje D.C., Collins W.E., et al. Community-based malaria control in Saradidi, Kenya: description of the programme and impact on parasitaemia rates and antimalarial antibodies. Ann Trop Med Parasitol 81 suppl 1 (1987) 13-23
29. Greenwood B.M., Bradley A.K., Greenwood A.M., et al. Mortality and morbidity from malaria among children in a rural area of The Gambia, West Africa. Trans R Soc Trop Med Hyg 81 (1987) 478-486
30. Menon A., Snow R.W., Byass P., Greenwood B.M., Hayes R.J., and N'Jie A.B. Sustained protection against mortality and morbidity from malaria in rural Gambian children by chemoprophylaxis given by village health workers. Trans R Soc Trop Med Hyg 84 (1990) 768-772
31. Delacollette C., Van der Stuyft P., and Molima K. Using community health workers for malaria control: experience in Zaire. Bull World Health Organ 74 (1996) 423-430
32. Kidane G., and Morrow R.H. Teaching mothers to provide home treatment of malaria in Tigray, Ethiopia: a randomised trial. Lancet 356 (2000) 550-555
33. Kouyate B., Some F., Jahn A., et al. Process and effects of a community intervention on malaria in rural Burkina Faso: randomized controlled trial. Malar J 7 (2008) 50
34. Chinbuah A.M., Gyapong J.O., Pagnoni F., Wellington E.K., and Gyapong M. Feasibility and acceptability of the use of artemether-lumefantrine in the home management of uncomplicated malaria in children 6-59 months old in Ghana. Trop Med Int Health 11 (2006) 1003-1016
35. Ajayi I.O., Browne E.N., Garshong B., et al. Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites. Malar J 7 (2008) 6
36. Bhattarai A., Ali A.S., Kachur S.P., et al. Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar. PLoS Med 4 (2007) e309
37. Okiro E.A., Hay S.I., Gikandi P.W., et al. The decline in paediatric malaria admissions on the coast of Kenya. Malar J 6 (2007) 151
38. Reyburn H., Mbakilwa H., Mwangi R., et al. Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial. BMJ 334 (2007) 403
39. Goodman CA, Coleman PG, Mills AJ. Cost-effectiveness of malaria control in sub-Saharan Africa. Lancet 354: 378-85.