Effect of quercetin on oxidative nuclear and mitochondrial DNA damage

BioFactors

Volumn 33, Issue 1, 2008, Pages 33-48

  Potenza, Lucia ^a   Calcabrini, Cinzia ^a   De Bellis, Roberta ^a   Mancini, Umberto ^a   Cucchiarini, Luigi ^a   Dach, Marina ^b  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

Mitochondrial DNA; NCTC 2544; Nuclear DNA; Oxidative damage; Quercetin

Indexed keywords

CELL NUCLEUS DNA; HYDROPEROXIDE; MITOCHONDRIAL DNA; PLASMID DNA; QUERCETIN; 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; ANTIOXIDANT; CHROMAN DERIVATIVE; HYDROGEN PEROXIDE; MIXED FUNCTION OXIDASE; TROLOX C;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL FREE SYSTEM; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DRUG EFFECT; HUMAN; HUMAN CELL; KERATINOCYTE; MITOCHONDRIAL GENOME; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ULTRAVIOLET C RADIATION; ULTRAVIOLET RADIATION; CELL CULTURE; CELL SURVIVAL; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; RADIATION EXPOSURE;

ANTIOXIDANTS; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CHROMANS; DNA DAMAGE; DNA, MITOCHONDRIAL; HUMANS; HYDROGEN PEROXIDE; KERATINOCYTES; MITOCHONDRIA; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; POLYMERASE CHAIN REACTION; QUERCETIN; ULTRAVIOLET RAYS;

EID: 65449176425     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520330104     Document Type: Article

References (59)

1. W. Adam, J. Hartung, H. Okamoto, C.R. Saha-Moller and K. Spehar, N-hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione as a photochemical hydroxyl-radical source: photochemistry and oxidative damage of DNA (strand breaks) and 2'-deoxyguanosine(8-oxodG formation), Photochem Photobiol 72 (2000), 619-624.
2. S. Anderson, A.T. Bankier, B.G. Barrell, M.H.L. deBruijn, A.R. Coulsen, J. Drouin, I.C. Eperon, B.A. Roe, F. Sanger, P.H. Scheir, R. Staden and I.G. Young, Sequence and organization of the human mitochondrial genome, Nature 290 (1981), 457-46.
3. S. Ayala-Torres, Y. Chen, T. Svoboda, J. Rosenblatt and B. Van Houten, Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction, Methods 22 (2000), 135-147.
4. S.W. Ballinger, B. Van Houten, G.F. Jin, C.A. Conklin and B.F. Godley, Hydrogen peroxide causes significant mitochon-drial DNA damage in human RPE cells, Exp Eye Res 68 (1999), 765-772.
5. I. Banmeyer, C. Marchand, A. Clippe and B. Knoops, Human mitochondrial peroxireodin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide, FEBS Lett 579 (2005), 2327-2333.
6. E. Beutler, Lactate Dehydrogenase (LDH), in: Red Cell Metabolism, A Manual of Biochemical Methods, (3rd ed.), Grune and Stratton, eds, Harcourt B. Jovanovich, New York, 1957, pp. 65-66.
7. V.A. Bohr, Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells, Free Radical Biol Med 32 (2002), 804-812.
8. A.W. Boots, H. Li, R.P.F. Schino, R. Duffin, J.W.M. Heemskerk, A. Bast and G.R.M.M. Haenen, The quercetin paradox, Toxicol Appl Pharm 222 (2007), 89-96.
9. J. Cao, L. Jia, H.M. Zhou, Y. Liu and L.F. Zhong, Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells, Toxicol Sci 91 (2006), 476-483.
10. R. Casagrande, S.R. Georgetti, W.A. Jr Verri, D.J. Dorta, A.C. dos Santos and M.J. Fonseca, Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice, J Photoch and Photobio B 84 (2006), 21-27.
11. R. Casagrande, S.R. Georgetti, W.A. Jr Verri, D.J. Dorta, A.C. dos Santos and M.J. Fonseca, In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity, J Photoch and Photobio B 328 (2007), 183-190.
12. M.S. Cooke, M.D. Evans, M. Dizdaroglu and J. Lunec, Oxidative DNA damage: mechanisms, mutation, and disease, FASEB J 17 (2003), 1195-1214.
13. N.A. Cridland, M.C. Martin, K. Stevens, C.A. Baller, A.J. Pearson, C.M. Driscoll and R.D. Saunders, Role of stress responses in human cell survival following exposure to ultraviolet C radiation, Int J Radiat Biol 77 (2001), 365-374.
14. S. De, C. Ganguly and S. Das, Natural dietary agents can protect against DMBA genotoxicity in lymphocytes as revealed by single cell gel electrophoresis assay, Teratog Carcinog Mutagen Suppl 1 (2003), 71-78.
15. G. Deng, J.H. Su, K.J. Ivins, B. Van Houten and C.W. Cotman, Bcl-2 facilitates recovery from DNA damage after oxidative stress, Exp Neurol 159 (1999), 309-318.
16. M.M. Dobrzyńska, A. Baumgartner and D. Anderson, Antioxidants modulate thyroid hormone- and noradrenaline-induced DNA damage in human sperm, Mutagenesis 19 (2005), 325-330.
17. D.J. Dorta, A.A. Pigoso, F.E. Mingatto, T. Rodrigues, I.M. Prado, A.F. Helena, S.A. Uyemura, A.C. Santos and C. Curti, The interaction of flavonoids with mitochondria: effects on energetic processes, Chem Biol Interact 152 (2005), 67-78.
18. R. Edenharder, J.W. Sager, H. Glatt, E. Muckel and K.L. Platt, Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1metil-6-phenylimidazo [4,5-b] pyridine (PhIP) in metabolically competent V79 cells, Mutat Res 521 (2002), 71-78.
19. I. Erlund, Review of the flavonoids quercetin, hesperetin and narigenin. Dietary sources, bioactivities, bioavality and epidemiology, Nutr Res 24 (2004), 851-874.
20. R. Fagiani, A. De Bartolomeo, P. Rosignoli and G. Morozzi, Antioxidants prevent the lymphocyte DNA damage induced by PMA-stimulated monocytes, Nutr Cancer 39 (2002), 284-291.
21. P. Filipe, J.N. Silva, J. Haigle, J. Freitas, A. Fernandes, R. Santus and P. Molière, Contrasting action of flavonoids on phototoxic effects induced in human skin fibroblast by UVA alone or UVA plus cyamemazine, a phototoxic neuroleptic, Photoch Photobio Sci 4 (2005), 420-428.
22. J.V. Formica and W. Regelson, Review of the Biology of quercetin and related bioflavonoids, Food Chem Toxicol 33 (1995), 1061-1080.
23. J.R. Gledhill, M.G. Montgomery, A.G. Leslie, J.E. Walker, Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols, Proc Natl Acad Sci USA 104 (2007), 13632-13637.
24. B.F. Godley, F.A. Shamsi, F.Q. Liang, S.G. Jarrett, S. Davies and M. Boulton, Blue light induces mitochondrial DNA damage and free radical production in epithelial cells, J Biol Chem 280 (2005), 21061-21066.
25. C. Guidi, L. Potenza, P. Sestili, C. Martinelli, M. Guescini, L. Stocchi, S. Zeppa, E. Polidori, G. Annibalini and V. Stocchi, Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA, Biochim Biophys Acta 1780 (2008), 16-26.
26. K.E. Heim, A.R. Tagliaferro and D.J. Bobilya, Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships, J Nutr Biochem 13 (2002), 572-584.
27. K. Igura, T. Ohta, Y. Kuroda and K. Kaji, Resveratrol and quercetin inhibit angiogenesis in vitro, Cancer Lett 171 (2001), 11-16.
28. C.D. Kanakis, P.A. Tarantilis, M.G. Polissiou, S. Diamantoglou, H.A. Tajmir-Riahi, An overview of DNA and RNA bindings to antioxidant flavonoids, Cell Biochem Biophys 49 (2007), 29-36.
29. M. Kapiszewska, A. Cierniak, M. Elas and A. Lankoff, Lifespan of etoposide-treated human neutrophils is affected by antioxidant ability of quercetin, Toxicol In Vitro 21 (2007), 1020-1030.
30. D.M. Kending and J.B. Tarloff, Inactivation of lactate dehydrogenase by several chemicals: implications for in vitro toxicology studies, Toxicol In Vitro 21 (2007), 125-132.
31. 2 mixed-function oxidation system, J Biol Chem 263 (1988), 4704-4711.
32. N. Llópiz, F. Puiggròs, E. Céspedes, L. Arola, A. Ardévol and C. Bladé, Antigenotoxic effect of grape seed procyanidin extract in Fao cells submitted to oxidative stress, J Agr Food Chem 52 (2004), 1083-1087.
33. G.M. Makrigiorgos, E. Bump, C. Huang, J. Baranowska-Kortylewicz and A.I. Kassis, A fluorimetric method for the detection of copper-mediated hydroxyl free radicals in the immediate proximity of DNA, Free Radical Biol Med 18 (1995), 669-678.
34. B.S. Mandavilli, S.F. Ali and B. Van Houten, DNA damage in brain mitochondria caused by aging and MPTP treatment, Brain Res 885 (2000), 45-52.
35. M. Meriyani Odyuo and R.N. Sharan, Differential DNA strand breaking abilitiesofOH and ROS generating radiomimetic chemicals and gamma-rays: study of plasmid DNA, pMTa4, in vitro, Free Radical Res 39 (2005), 499-505.
36. E.J. Middleton, Effect of plant flavonoids on immune and inflammatory cell function, Adv Exp Med Biol 439 (1998), 175-182.
37. M. Mochizuki, K. Kajiya, J. Terao K. Kaji, S. Kumazawa, T. Shimoi, Effect of quercetin conjugates on vascular ermeability and expression of adhesion molecules, Biofactors 22 (2004), 201-204.
38. A. Murakami, H. Ashida and J. Terao, Multitargeted cancer prevention by quercetin, Cancer Lett, 2008 May 6, [Epub ahead of print].
39. N. Neznanov, A. Kondratova, K.M. Chumakov, L. Neznanova, R. Kondratov, A.K. Banerjee and A.V. Gudkov, Querceti-nase Pirin Makes Poliovirus Replication Resistant to Flavonoid Quercetin, DNA Cell Biol 27 (2008), 191-198.
40. P. Niu, L. Liu, Z. Gong, H. Tan, F. Wang, J. Yuan, Y. Feng, Q. Wei, R.M. Tanguay and T. Wu, Overexpressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner, Cell Stress Chaperon 11 (2006), 162-169.
41. B. Pawlikowska-Pawlega, W.I. Gruszecki, L. Misiak, R. Paduch, T. Piersiak, B. Zarzyka, J. Pawelec and A. Gawron, Modification of membranes by quercetin, a naturally occurring flavonoid, via its incorporation in the polar head group, Biochim Biophys Acta 1768 (2007), 2195-2204.
42. J.H. Santos, B.S. Mandavilli and B. Van Houten, Measuring oxidative mtDNA damage and repair using quantitative PCR, Methods Mol Biol 197 (2002), 159-176.
43. J.H. Santos, L. Hunakova, Y. Chen, C. Bortner and B. Van Houten, Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death, J Biol Chem 278 (2003), 1728-1734.
44. D.E. Sawyer and B. Van Houten, Repair of DNA damage in mitochondria, Mutat Res 434 (1999), 161-176.
45. J.A. Sikorsky, D.A. Primerano, T.W. Fenger and J. Denvir, Effect of DNA damage on PCR amplification efficiency with the relative threshold cycle method, Biochem Biophys Res Commun 323 (2004), 823-830.
46. Y.Y.M. Su and G. Yang, Quantitative measurement of hydroxyl radical induced DNA double-strand breaks and the effect of N-acetyl-L-cysteine, FEBS Lett 580 (2006), 4136-4142.
47. 2-induced oxidative stress in human keratinocytes and mouse fibroblast, Burns 32 (2006), 973-979.
48. Y.T. Szeto and I.F. Benzie, Effects of dietary antioxidants on human DNA damage in lysed cells using a modified comet assay procedure, Free Radic Res 500 (2002), 31-38.
49. Y.T. Szeto and I.F. Benzie, Effects of dietary antioxidants on human DNA ex vivo, Free Radic Res 36 (2002), 113-118.
50. X.L. Tang, X.J. Liu, W.M. Sun, J. Zhao and R.L. Zheng, Oxidative stress in Graves'disease patients and antioxidant protection against lymphocytes DNA damage in vitro, Pharmazie 60 (2005), 696-700.
51. J. Tieppo, R. Vercelino, A.S. Dias, M.F. Silva Vaz, T.R. Silveira, C.A. Marroni, N.P. Marroni, J.A. Henriques and J.N. Picada, Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome, Food Chem Toxicol 45 (2007), 1140-1146.
52. V.W.B. Van Houten and J.H. Santos, Role of mitochondrial DNA in toxic response to oxidative stress, DNA Repair 5 (2006), 145-152.
53. L.C. Wilms, P.C. Hollman, A.W. Boots and J.C. Kleinjans, Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes, Mutat Res 582 (2005), 155-162.
54. L.C. Wilms, T.A. Claughton, T.M. de Kok and J.C. Kleinjans, GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro, Food Chem Toxicol 45 (2007), 2592-2596.
55. L.C. Wilms, A.W. Boots, V.C. de Boer, L.M. Maas, D.M. Pachen, R.W. Gottschalk, H.B Ketelslegers, R.W. Godshalk, G.R. Haenen, F.J. van Schooten and J.C. Kleinjans, Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers, Carcinogenesis 28 (2007), 1800-1806.
56. L.C. Wilms, J.C. Kleinjans, E.J. Moonen and J.J. Briedé Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro, Toxicol In Vitro 22 (2008), 301-307.
57. F.M. Yakes and B. Van Houten, Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress, Proc Natl Acad Sci USA 94 (1997), 514-519.
58. S.L. Yeh, W.Y. Wang, C.H. Hang and M.L. Hu, Pro-oxidative effect of beta-carotene and the interaction with flavonoids on UVA-induced DNA strand breaks in mouse fibroblast C3H10T1/2 cells, J Nutr Biochem 16 (2005), 729-735.
59. J. Zhao and X.J. Liu, Antioxidative and immunomodulatory role of melatonin, sodium selenite, N-acetyl-L-cysteine and quercetin on human umbelical blood, Pharmazie 60 (2005), 683-688.