Performance of clinical algorithms for HIV-1 diagnosis and antiretroviral initiation among HIV-1-exposed children aged less than 18 months in Kenya

Journal of Acquired Immune Deficiency Syndromes

Volumn 50, Issue 5, 2009, Pages 492-498

  Inwani, Irene ^a   Mbori Ngacha, Dorothy ^b   Nduati, Ruth ^b   Obimbo, Elizabeth ^b   Wamalwa, Dalton ^b   John Stewart, Grace ^c   Farquhar, Carey ^c  

^a KENYATTA NATIONAL HOSPITAL   (Kenya)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Clinical algorithms; HIV 1; Infant diagnosis

Indexed keywords

ANTIRETROVIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGE DISTRIBUTION; ANTIVIRAL THERAPY; ARTICLE; CAREGIVER; CD4 LYMPHOCYTE COUNT; CHILD; CLASSIFICATION ALGORITHM; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; DNA DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFANT; KENYA; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SERODIAGNOSIS; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME; VIRUS DIAGNOSIS; WORLD HEALTH ORGANIZATION; ADULT; ALGORITHM; BLOOD; CROSS-SECTIONAL STUDY; DISEASE TRANSMISSION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PREDICTION AND FORECASTING; PREGNANCY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

ADULT; ALGORITHMS; ANTI-HIV AGENTS; CROSS-SECTIONAL STUDIES; FEMALE; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; KENYA; MALE; PREDICTIVE VALUE OF TESTS; PREGNANCY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 65449165286     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318198a8a4     Document Type: Article

References (22)

1. Newell ML, Coovadia H, Cortina-Borja M, et al. Mortality of infected and uninfected infants born to HIV infected mothers in Africa: a pooled analysis. Lancet. 2004;364:1236-1243.
2. Obimbo E, Mbori-Ngacha D, Ochieng J, et al. Predictors of early mortality in a cohort of human immunodeficiency virus type 1-infected African children. Pediatr Infect Dis J. 2004;23:536-545.
3. Cherutich P, Inwani I, Nduati R, et al. Optimizing paediatric HIV care in Kenya: challenges in early infant diagnosis. Bull World Health Organ. 2008;86:155-160.
4. Sherman GG, Cooper PA, Coovadia AH, et al. Polymerase chain reaction for diagnosis of human immunodeficiency virus infection in infants in low resource settings. Pediatr Infect Dis J. 2005;24:993-997.
5. Zijenah LS, Humphrey J, Nathoo K, et al. Evaluation of the prototype Roche DNA amplification kit incorporating the new SSK145 and SKCC1B primers in detection of human immunodeficiency virus type 1 DNA in Zimbabwe. J Clin Microbiol. 1999;37:3569-3571.
6. Beck IA, Drennan KD, Melvin AJ, et al. Simple, sensitive, and specific detection of human immunodeficiency virus type 1 subtype B DNA in dried blood samples for diagnosis in infants in the field. J Clin Microbiol. 2001;39:29-33.
7. Cassol S, Butcher A, Kinard S, et al. Rapid screening for early detection of mother-to-child transmission of human immunodeficiency virus type 1. J Clin Microbiol. 1994;32:2641-2645.
8. Fischer A, Lejczak C, Lambert C, et al. Simple DNA extraction method for dried blood spots and comparison of two PCR assays for diagnosis of vertical human immunodeficiency virus type 1 transmission in Rwanda. J Clin Microbiol. 2004;42:16-20.
9. Nyambi PN, Fransen K, De Beenhouwer H, et al. Detection of human immunodeficiency virus type 1 (HIV-1) in heel prick blood on filter paper from children born to HIV-1 seropositive mothers. J Clin Microbiol. 1994; 32:2858-2860.
10. Sherman GG, Stevens G, Jones SA, et al. Dried blood spots improve access to HIV diagnosis and care for infants in low-resource settings. J Acquir Immune Defic Syndr. 2005;38:615-617.
11. World Health Organization Division of Diarrhoeal and Acute Respiratory Disease Control. Integrated management of the sick child. Bull World Health Organ. 1995;73:735-740.
12. Gove S. Integrated management of childhood illness by outpatient health workers: technical basis and overview. Bull World Health Organ. 1997; 75(Suppl 1):7-16.
13. Nduati R, John G, Mbori-Ngacha D, et al. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial. JAMA. 2000;282:1167-1174.
14. Jones SA, Sherman GG, Coovadia AH. Can clinical algorithms deliver an accurate diagnosis of HIV infection in infancy? Bull World Health Organ. 2005;83:559-560.
15. Horwood C, Liebeschuetz S, Blaauw D, et al. Diagnosis of paediatric HIV infection in a primary health care setting with a clinical algorithm. Bull World Health Organ. 2003;81:858-866.
16. Chintu C, Bhat GJ, Walker AS, et al. Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomized placebo-controlled trial. Lancet. 2004;364:1865-1871.
17. Zijenah LS, Katzenstein DA, Nathoo KJ, et al. T lymphocytes among HIV-infected and uninfected infants: CD4/CD8 ratio as a potential tool in diagnosis of infection in infants under the age of 2 years. J Transl Med. 2005;3:3-6.
18. Embree J, Bwayo J, Nagelkerke N, et al. Lymphocyte subsets in human immunodeficiency virus type 1 infected and uninfected children in Nairobi. Pediatr Infect Dis J. 2001;20:397-403.
19. Berman S. Overview of pneumonia in early infancy. In: Gadomski A, ed. Acute Respiratory Infection and Child Survival in Developing Countries, Understanding the Current Status and Directions for the 1990s. Baltimore, MD: Institute for International Programs, Johns Hopkins University; 1990:39-52.
20. Voorhoeve AM, Muller AS, Schulpen TWJ, et al. Machakos project studies: agents affecting health of mother and child in a rural area of Kenya. IV: the epidemiology of pertussis. Trop Geogr Med. 1978;30: 125-139.
21. Greenwood BM, Bradley AK, Greenwood AM, et al. Mortality and morbidity from malaria among children in a rural area of The Gambia, West Africa. Trans R Soc Trop Med Hyg. 1987;81:478-486.
22. Trape JF, Zoulani A, Quinet MC. Assessment of the incidence and prevalence of clinical malaria in semi-immune children exposed to intense and perennial transmission. Am J Epidemiol. 1987;126:193-201.