Phenotypic and functional characterization of HIV-1-specific CD4 +CD8 + double-positive T cells in early and chronic HIV-1 infection

Journal of Acquired Immune Deficiency Syndromes

Volumn 50, Issue 5, 2009, Pages 444-456

  Howe, Rawleigh ^a   Dillon, Stephanie ^a   Rogers, Lisa ^a   Palmer, Brent ^a   Mawhinney, Samantha ^a   Blyveis, Naomi ^a   Schlichtemeier, Rick ^a   D'Souza, Michelle ^a   Ingoldby, Laura ^a   Harwood, Jeri E F ^a   Rietmeijer, Cornelis ^b   Ray, Graham ^a   Connick, Elizabeth ^a   Wilson, Cara C ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b Denver Department of Public Health ^*  (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

CD4 +CD8 +; Early infection; HIV 1; IFN gamma; T lymphocytes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; CYTOKINE;

ADULT; ARTICLE; CD4 CD8 RATIO; CELL MATURATION; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VIRUS LOAD;

ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CYTOKINES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; PHENOTYPE; VIRAL LOAD; YOUNG ADULT;

EID: 65449164663     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31819aa8c4     Document Type: Article

References (54)

1. Zuckermann FA. Extrathymic CD4/CD8 double positive T cells. Vet Immunol Immunopathol. 1999;72:55-66.
2. Parel Y, Chizzolini C. CD4+ CD8+ double positive (DP) T cells in health and disease. Autoimmun Rev. 2004;3:215-220.
3. Blue ML, Daley JF, Levine H, et al. Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry. J Immunol. 1985;134:2281-2286.
4. Nam K, Akari H, Terao K, et al. Peripheral blood extrathymic CD4(+)CD8(+) T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(-) T cells in cynomolgus monkeys. Int Immunol. 2000;12:1095-1103.
5. Suni MA, Ghanekar SA, Houck DW, et al. CD4(+)CD8(dim) T lymphocytes exhibit enhanced cytokine expression, proliferation and cytotoxic activity in response to HCMV and HIV-1 antigens. Eur J Immunol. 2001;31:2512-2520.
6. Ortolani C, Forti E, Radin E, et al. Cytofluorimetric identification of two populations of double positive (CD4+, CD8+) T lymphocytes in human peripheral blood. Biochem Biophys Res Commun. 1993;191:601-609.
7. Pahar B, Lackner AA, Veazey RS. Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines. Eur J Immunol. 2006;36:583-592.
8. Zloza A, Sullivan YB, Connick E, et al. CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV. Blood. 2003;102:2156-2164.
9. Sullivan YB, Landay AL, Zack JA, et al. Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells. Immunology. 2001;103:270-280.
10. Kitchen SG, Korin YD, Roth MD, et al. Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J Virol. 1998;72:9054-9060.
11. Flamand L, Crowley RW, Lusso P, et al. Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis. Proc Natl Acad Sci U S A. 1998;95: 3111-3116.
12. Reimann J, Rudolphi A. Co-expression of CD8 alpha in CD4+ T cell receptor alpha beta + T cells migrating into the murine small intestine epithelial layer. Eur J Immunol. 1995;25:1580-1588.
13. Zuckermann FA, Husmann RJ. Functional and phenotypic analysis of porcine peripheral blood CD4/CD8 double-positive T cells. Immunology. 1996;87:500-512.
14. Iwatani Y, Hidaka Y, Matsuzuka F, et al. Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3loTCR alpha beta lo/-CD4-CD8-cells, in autoimmune thyroid disease. Clin Exp Immunol. 1993;93:430-436.
15. Bang K, Lund M, Wu K, et al. CD4+ CD8+ (thymocyte-like) T lymphocytes present in blood and skin from patients with atopic dermatitis suggest immune dysregulation. Br J Dermatol. 2001;144:1140-1147.
16. De Maria A, Malnati M, Moretta A, et al. CD3 + 4-8-WT31-(T cell receptor gamma+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2-responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis. Eur J Immunol. 1987;17:1815-1819.
17. Hirao J, Sugita K. Circulating CD4+CD8+ T lymphocytes in patients with Kawasaki disease. Clin Exp Immunol. 1998;111:397-401.
18. Munschauer FE, Stewart C, Jacobs L, et al. Circulating CD3+ CD4+ CD8+ T lymphocytes in multiple sclerosis. J Clin Immunol. 1993;13: 113-118.
19. Senju M, Wu KC, Mahida YR, et al. Coexpression of CD4 and CD8 on peripheral blood T cells and lamina propria T cells in inflammatory bowel disease by two colour immunofluorescence and flow cytometric analysis. Gut. 1991;32:918-922.
20. Nascimbeni M, Shin EC, Chiriboga L, et al. Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood. 2004;104:478-486.
21. Ober BT, Summerfield A, Mattlinger C, et al. Vaccine-induced, pseudorabies virus-specific, extrathymic CD4+CD8+ memory T-helper cells in swine. J Virol. 1998;72:4866-4873.
22. Hillemeyer P, White MD, Pascual DW. Development of a transient CD4(+)CD8(+) T cell subset in the cervical lymph nodes following intratracheal instillation with an adenovirus vector. Cell Immunol. 2002; 215:173-185.
23. Periwal SB, Cebra JJ. Respiratory mucosal immunization with reovirus serotype 1/L stimulates virus-specific humoral and cellular immune responses, including double-positive (CD4(+)/CD8(+)) T cells. J Virol. 1999;73:7633-7640.
24. Helgeland L, Johansen FE, Utgaard JO, et al. Oligoclonality of rat intestinal intraepithelial T lymphocytes: overlapping TCR beta-chain repertoires in the CD4 single-positive and CD4/CD8 double-positive subsets. J Immunol. 1999;162:2683-2692.
25. Herndler-Brandstetter D, Schwanninger A, Grubeck-Loebenstein B. CD4+ CD8+ T cells in young and elderly humans. Comment on Macchia I, Gauduin MC, Kaur A, Johnson RP. Expression of CD8alpha identifies a distinct subset of effector memory CD4 T lymphocytes. Immunology 2006;119:232-242. Immunology. 2007;120:292-294.
26. Lefrancois L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol. 1991;147:1746-1751.
27. Mosley RL, Styre D, Klein JR. CD4+CD8+ murine intestinal intraepithelial lymphocytes. Int Immunol. 1990;2:361-365.
28. Abuzakouk M, Carton J, Feighery C, et al. CD4+ CD8+ and CD8alpha+ beta-T lymphocytes in human small intestinal lamina propria. Eur J Gastroenterol Hepatol. 1998;10:325-329.
29. Akari H, Terao K, Murayama Y, et al. Peripheral blood CD4+CD8+ lymphocytes in cynomolgus monkeys are of resting memory T lineage. Int Immunol. 1997;9:591-597.
30. Jarry A, Cerf-Bensussan N, Brousse N, et al. Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3-lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol. 1990;20:1097-1103.
31. Zloza A, Al-Harthi L. Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration. J Leukoc Biol. 2006;79:4-6.
32. Yang LP, Riley JL, Carroll RG, et al. Productive infection of neonatal CD8+ T lymphocytes by HIV-1. J Exp Med. 1998;187:1139-1144.
33. Imlach S, McBreen S, Shirafuji T, et al. Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. J Virol. 2001;75:11555-11564.
34. Hughes GJ, Cochrane A, Leen C, et al. HIV-1-infected CD8+CD4+ T cells decay in vivo at a similar rate to infected CD4 T cells during HAART. AIDS. 2008;22:57-65.
35. Cochrane A, Imlach S, Leen C, et al. High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo. J Virol. 2004;78:9862-9871.
36. Brenchley JM, Hill BJ, Ambrozak DR, et al. T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol. 2004;78:1160-1168.
37. Veazey RS, Mansfield KG, Tham IC, et al. Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection. J Virol. 2000;74:11001-11007.
38. Macchia I, Gauduin MC, Kaur A, et al. Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes. Immunology. 2006;119:232-242.
39. Mattapallil JJ, Reay E, Dandekar S. An early expansion of CD8alphabeta T cells, but depletion of resident CD8alphaalpha T cells, occurs in the intestinal epithelium during primary simian immunodeficiency virus infection. AIDS. 2000;14:637-646.
40. Weiss L, Roux A, Garcia S, et al. Persistent expansion, in a human immunodeficiency virus-infected person, of V beta-restricted CD4+CD8+ T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha. J Infect Dis. 1998;178:1158-1162.
41. Betts MR, Nason MC, West SM, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 2006;107: 4781-4789.
42. Migueles SA, Laborico AC, Shupert WL, et al. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol. 2002;3:1061-1068.
43. Guadalupe M, Sankaran S, George MD, et al. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunode-ficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J Virol. 2006;80:8236-8247.
44. Mellors JW, Rinaldo CR Jr, Gupta P, et al. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science. 1996;272:1167-1170.
45. Parekh BS, Kennedy MS, Dobbs T, et al. Quantitative detection of increasing HIV type 1 antibodies after seroconversion: a simple assay for detecting recent HIV infection and estimating incidence. AIDS Res Hum Retroviruses. 2002;18:295-307.
46. Betts MR, Brenchley JM, Price DA, et al. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods. 2003;281:65-78.
47. Schmitz JE, Forman MA, Lifton MA, et al. Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunode-ficiency virus+ individuals. Blood. 1998;92:198-206.
48. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004;22:745-763.
49. Palmer BE, Boritz E, Wilson CC. Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4+ T cell maturation and function. J Immunol. 2004;172:3337-3347.
50. Emu B, Sinclair E, Favre D, et al. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol. 2005;79:14169-14178.
51. Harari A, Petitpierre S, Vallelian F, et al. Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy. Blood. 2004;103:966-972.
52. Younes SA, Yassine-Diab B, Dumont AR, et al. HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J Exp Med. 2003;198: 1909-1922.
53. Champagne P, Ogg GS, King AS, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001;410:106-111.
54. Pantaleo G, Graziosi C, Demarest JF, et al. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev. 1994;140:105-130.