Splenic follicular lymphoma: Clinicopathologic characteristics of a series of 32 cases

American Journal of Surgical Pathology

Volumn 33, Issue 5, 2009, Pages 730-738

  Mollejo, Manuela ^a   Rodríguez Pinilla, María S ^d   Montes Moreno, Santiago ^d   Algara, Patrocinio ^b   Dogan, Ahmet ^f   Cigudosa, Juan C ^e   Juarez, Rocío ^a   Flores, Teresa ^g   Forteza, Jerónimo ^h   Arribas, Alberto ^c   Piris, Miguel A ^d,e  

^a Pathology Department

^b Genetics Department

^c HOSPITAL VIRGEN DE LA SALUD   (Spain)

^d Molecular Pathology Programme   (Spain)

^e Centro Nacional de Investigaciones Oncológicas   (Spain)

^f MAYO CLINIC   (United States)

^g HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^h Instituto de Salud Carlos III   (Spain)

Author keywords

Bcl2; Follicular lymphoma; Spleen

Indexed keywords

CD20 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; IMMUNOGLOBULIN D; INTERFERON REGULATORY FACTOR 4; KI 67 ANTIGEN; PREDNISONE; PROTEIN BCL 2; PROTEIN BCL 6; PROTEIN P53; VINCRISTINE; MEMBRANE METALLOENDOPEPTIDASE;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER RELAPSE; CANCER SURVIVAL; CELL PROLIFERATION; CHROMOSOME 14; CHROMOSOME 18; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GERMINAL CENTER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LARGE CELL LYMPHOMA; LYMPHADENOPATHY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; SPLENECTOMY; SPLENIC MARGINAL ZONE LYMPHOMA; SPLENOMEGALY; B CELL LYMPHOMA; CANCER STAGING; CHEMISTRY; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR LYMPHOMA; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; PATHOLOGY; POLYMERASE CHAIN REACTION; RECURRENT DISEASE; SPLEEN TUMOR; TIME; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; CELL PROLIFERATION; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KAPLAN-MEIERS ESTIMATE; LYMPHOMA, B-CELL; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; NEOPLASM STAGING; NEPRILYSIN; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; RECURRENCE; SPLENIC NEOPLASMS; SPLENOMEGALY; TIME FACTORS; TREATMENT OUTCOME;

EID: 65449153567     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318193fcef     Document Type: Article

References (21)

1. Adam P, Katzenberger T, Eifert M, et al. Presence of preserved reactive germinal centers in follicular lymphoma is a strong histopathologic indicator of limited disease stage. Am J Surg Pathol. 2005;29:1661-1664.
2. Bacon CM, Ye H, Diss TC, et al. Primary follicular lymphoma of the testis and epididymis in adults. Am J Surg Pathol. 2007;31: 1050-1058.
3. Bende RJ, Smit LA, Bossenbroek JG, et al. Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells. Am J Pathol. 2003;162:105-113.
4. Chacon JI, Mollejo M, Munoz E, et al. Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients. Blood. 2002;100:1648-5164.
5. Cheson BD, Pfistner B, Juweid ME, et al. Revised response criteria for malignant lymphoma. J Clin Oncol. 2007;25:579-586.
6. Goodlad JR, Batstone PJ, Hamilton DA, et al. BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma. Histopathology. 2006;49:229-241.
7. Jaffe ESHN, Stein H, Vardiman JW. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumors. Lyon: IARC Press; 2001: 162-167.
8. Kansal R, Ross CW, Singleton TP, et al. Histopathologic features of splenic small B-cell lymphomas. A study of 42 cases with a definitive diagnosis by the World Health Organization classification. Am J Clin Pathol. 2003;120:335-347.
9. - MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features. Blood. 2007;109:3076-3079.
10. Kim BK, Surti U, Pandya A, et al. Clinicopathologic, immunophe-notypic, and molecular cytogenetic fluorescence in situ hybridization analysis of primary and secondary cutaneous follicular lymphomas. Am J Surg Pathol. 2005;29:69-82.
11. Koster A, Tromp HA, Raemaekers JM, et al. The prognostic significance of the intra-follicular tumor cell proliferative rate in follicular lymphoma. Haematologica. 2007;92:184-190.
12. Martin AR, Weisenburger DD, Chan WC, et al. Prognostic value of cellular proliferation and histologic grade in follicular lymphoma. Blood. 1995;85:3671-3678.
13. Mattia AR, Ferry JA, Harris NL. Breast lymphoma. A B-cell spectrum including the low grade B-cell lymphoma of mucosa associated lymphoid tissue. Am J Surg Pathol. 1993;17:574-587.
14. Matutes E, Oscier D, Montalban C, et al. Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria. Leukemia. 2008;22:487-495.
15. Mollejo M, Lloret E, Menarguez J, et al. Lymph node involvement by splenic marginal zone lymphoma: morphological and immunohistochemical features. Am J Surg Pathol. 1997;21:772-780.
16. Naresh KN. MUM1 expression dichotomises follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes. Haematologica. 2007;92:267-268.
17. Piris MA, Mollejo M, Campo E, et al. A marginal zone pattern may be found in different varieties of non-Hodgkin's lymphoma: the morphology and immunohistology of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma. Histopathology. 1998;33:230-239.
18. Remstein ED, Law M, Mollejo M, et al. The prevalence of IG translocations and 7q32 deletions in splenic marginal zone lymphoma. Leukemia. 2008;22:1268-1272.
19. Solal-Celigny P, Roy P, Colombat P, et al. Follicular lymphoma international prognostic index. Blood. 2004;104:1258-1265.
20. Van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the biomed-2 concerted action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.
21. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768-3785.