메뉴 건너뛰기




Volumn 11, Issue SUPPL. 2, 2009, Pages 9-17

The scientific evidence: Vildagliptin and the benefits of islet enhancement

Author keywords

Dipeptidyl peptidase 4; Glucagon like peptide 1; Incretins; Islet enhancement; Vildagliptin; cell function

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; GLUCAGON LIKE PEPTIDE 1; INCRETIN; METFORMIN; PLACEBO; VILDAGLIPTIN;

EID: 65449151804     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.01033.x     Document Type: Review
Times cited : (23)

References (24)
  • 1
    • 0031961242 scopus 로고    scopus 로고
    • Beta cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: The 10-year follow-up of the Belfast Diet Study
    • Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR. Beta cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: The 10-year follow-up of the Belfast Diet Study. Diabet Med 1998; 15: 290-295.
    • (1998) Diabet Med , vol.15 , pp. 290-295
    • Levy, J.1    Atkinson, A.B.2    Bell, P.M.3    McCance, D.R.4    Hadden, D.R.5
  • 2
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006; 355: 2427-2443.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 3
    • 0014951784 scopus 로고
    • Abnormal alpha-cell function in diabetes: Response to carbohydrate and protein ingestion
    • Müller WA, Faloona GR, Aguilar-Parada E, Unger RH. Abnormal alpha-cell function in diabetes: Response to carbohydrate and protein ingestion. N Engl J Med 1970; 283: 109-115.
    • (1970) N Engl J Med , vol.283 , pp. 109-115
    • Müller, W.A.1    Faloona, G.R.2    Aguilar-Parada, E.3    Unger, R.H.4
  • 4
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Ørskov C, Holst JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993; 36: 741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Ørskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 5
    • 34147208931 scopus 로고    scopus 로고
    • Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT
    • He Y-L, Wang Y, Bullock JM et al. Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT. J Clin Pharmacol 2007; 47: 633-641.
    • (2007) J Clin Pharmacol , vol.47 , pp. 633-641
    • He, Y.-L.1    Wang, Y.2    Bullock, J.M.3
  • 6
    • 33749402707 scopus 로고    scopus 로고
    • Vildagliptin: A novel DPP-4 inhibitor with pancreatic islet enhancement activity for treatment of patients with type 2 diabetes
    • Ristic S, Bates PC. Vildagliptin: A novel DPP-4 inhibitor with pancreatic islet enhancement activity for treatment of patients with type 2 diabetes. Drugs Today 2006; 42: 519-531.
    • (2006) Drugs Today , vol.42 , pp. 519-531
    • Ristic, S.1    Bates, P.C.2
  • 7
    • 33751098267 scopus 로고    scopus 로고
    • Vildagliptin
    • Henness S, Keam SJ. Vildagliptin. Drugs 2006; 66: 1989-2001.
    • (2006) Drugs , vol.66 , pp. 1989-2001
    • Henness, S.1    Keam, S.J.2
  • 8
    • 37749015647 scopus 로고    scopus 로고
    • Evaluation of the potential for steady-state pharmacokinetic interaction between vildagliptin and simvastatin in healthy subjects
    • Ayalasomayajula SP, Dole K, He Y-L et al. Evaluation of the potential for steady-state pharmacokinetic interaction between vildagliptin and simvastatin in healthy subjects. Curr Med Res Opin 2007; 23: 2913-2920.
    • (2007) Curr Med Res Opin , vol.23 , pp. 2913-2920
    • Ayalasomayajula, S.P.1    Dole, K.2    He, Y.-L.3
  • 9
    • 34447628472 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers
    • He YL, Sabo R, Sunkara G et al. Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers. J Clin Pharmacol 2007; 47: 998-1004.
    • (2007) J Clin Pharmacol , vol.47 , pp. 998-1004
    • He, Y.L.1    Sabo, R.2    Sunkara, G.3
  • 10
    • 34249032779 scopus 로고    scopus 로고
    • Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
    • He YL, Sabo R, Riviere GJ et al. Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Curr Med Res Opin 2007; 23: 1131-1138.
    • (2007) Curr Med Res Opin , vol.23 , pp. 1131-1138
    • He, Y.L.1    Sabo, R.2    Riviere, G.J.3
  • 11
    • 37349024818 scopus 로고    scopus 로고
    • Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects
    • He YL, Ligueros-Saylan M, Sunkara G et al. Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects. J Clin Pharmacol 2008; 48: 85-95.
    • (2008) J Clin Pharmacol , vol.48 , pp. 85-95
    • He, Y.L.1    Ligueros-Saylan, M.2    Sunkara, G.3
  • 12
    • 34147189738 scopus 로고    scopus 로고
    • The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    • Balas B, Baig MR, Watson C et al. The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients. J Clin Endocrinol Metab 2007; 92: 1249-1255.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1249-1255
    • Balas, B.1    Baig, M.R.2    Watson, C.3
  • 13
    • 38149137991 scopus 로고    scopus 로고
    • Characterization of the influence of vildagliptin on model-assessed β-cell function in patients with type 2 diabetes and mild hyperglycemia
    • Mari A, Scherbaum WA, Nilsson PM et al. Characterization of the influence of vildagliptin on model-assessed β-cell function in patients with type 2 diabetes and mild hyperglycemia. J Clin Endocrinol Metab 2008; 93: 103-109.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 103-109
    • Mari, A.1    Scherbaum, W.A.2    Nilsson, P.M.3
  • 14
    • 53549129604 scopus 로고    scopus 로고
    • Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia
    • Scherbaum WA, Schweizer A, Mari A et al. Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia. Diabetes Obes Metab 2008; 10: 1114-1124.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1114-1124
    • Scherbaum, W.A.1    Schweizer, A.2    Mari, A.3
  • 15
    • 65449183926 scopus 로고    scopus 로고
    • Vildagliptin improves alpha cell glucose sensing in patients with type 2 diabetes
    • Abstract 75
    • Ahrén B, Schweizer S, Dejager S et al. Vildagliptin improves alpha cell glucose sensing in patients with type 2 diabetes. Diabetologia 2008; 51(Suppl. 1): S36-S37. Abstract 75.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Ahrén, B.1    Schweizer, S.2    Dejager, S.3
  • 16
    • 38149096290 scopus 로고    scopus 로고
    • Effects of the dipeptidyl peptidase inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance
    • Rosenstock J, Foley JE, Rendell M et al. Effects of the dipeptidyl peptidase inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance. Diabetes Care 2008; 31: 30-35.
    • (2008) Diabetes Care , vol.31 , pp. 30-35
    • Rosenstock, J.1    Foley, J.E.2    Rendell, M.3
  • 17
    • 0036435607 scopus 로고    scopus 로고
    • Enhanced secretion of glucagon-like peptide 1 by biguanide compounds
    • Yasuda N, Inoue T, Nagakura T et al. Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. Biochem Biophys Res Commun 2002; 298: 779-784.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 779-784
    • Yasuda, N.1    Inoue, T.2    Nagakura, T.3
  • 18
    • 0036298693 scopus 로고    scopus 로고
    • Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1
    • Hinke SA, Kühn-Wache K, Hoffmann T et al. Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1. Biochem Biophys Res Commun 2002; 291: 1302-1308.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 1302-1308
    • Hinke, S.A.1    Kühn-Wache, K.2    Hoffmann, T.3
  • 19
    • 36849045708 scopus 로고    scopus 로고
    • Sitagliptin, a selective DPP-4 inhibitor, and metformin have complementary effects to increase active GLP-1 concentrations
    • Abstract 0111
    • Migoya E, Miller J, Larson P et al. Sitagliptin, a selective DPP-4 inhibitor, and metformin have complementary effects to increase active GLP-1 concentrations. Diabetologia 2007; 50(Suppl. 1): S52. Abstract 0111.
    • (2007) Diabetologia , vol.50 , Issue.SUPPL. 1
    • Migoya, E.1    Miller, J.2    Larson, P.3
  • 20
    • 37349084444 scopus 로고    scopus 로고
    • Differential effects of DPP-4 inhibition on incretin hormone levels in drug-naïve and metformin-treated patients with type 2 diabetes
    • Abstract 0174
    • Dunning BE, Ligueros-Saylan M, D'Alessio DA et al. Differential effects of DPP-4 inhibition on incretin hormone levels in drug-naïve and metformin-treated patients with type 2 diabetes. Diabetologia 2006; 49(Suppl. 1): 110-111. Abstract 0174.
    • (2006) Diabetologia , vol.49 , Issue.SUPPL. 1 , pp. 110-111
    • Dunning, B.E.1    Ligueros-Saylan, M.2    D'Alessio, D.A.3
  • 21
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    • Ahrén B, Pacini G, Foley JE, Schweizer A. Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care 2005; 28: 1936-1940.
    • (2005) Diabetes Care , vol.28 , pp. 1936-1940
    • Ahrén, B.1    Pacini, G.2    Foley, J.E.3    Schweizer, A.4
  • 22
    • 39049141231 scopus 로고    scopus 로고
    • Measurements of islet function and glucose metabolism with the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes
    • Azuma K, RádikováZ, Mancino J et al. Measurements of islet function and glucose metabolism with the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes. J Clin Endocrinol Metab 2008; 93: 459-464.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 459-464
    • Azuma, K.1    Rádiková, Z.2    Mancino, J.3
  • 23
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • Matikainen N, Mänttäri S, Schweizer A et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia 2006; 49: 2049-2057.
    • (2006) Diabetologia , vol.49 , pp. 2049-2057
    • Matikainen, N.1    Mänttäri, S.2    Schweizer, A.3
  • 24
    • 34248169217 scopus 로고    scopus 로고
    • Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance and glucose metabolism in type 2 diabetes
    • Vella A, Bock G, Giesler PD et al. Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance and glucose metabolism in type 2 diabetes. Diabetes 2007; 56: 1475-1480.
    • (2007) Diabetes , vol.56 , pp. 1475-1480
    • Vella, A.1    Bock, G.2    Giesler, P.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.