Tracing the distribution and evolution of lactase persistence in southern Europe through the study of the T-13910 variant

American Journal of Human Biology

Volumn 21, Issue 2, 2009, Pages 217-219

  Anagnostou, Paolo ^a,b   Battaggia, Cinzia ^a   Coia, Valentina ^a,c   Capelli, Cristian ^d   Fabbri, Cristina ^b   Pettener, Davide ^b   Destro Bisol, Giovanni ^a,e   Luiselli, Donata ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF TRENTO   (Italy)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e Istituto Italiano di Antropologia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LACTASE;

ARTICLE; CONTROLLED STUDY; CULTURAL FACTOR; EUROPE; GENE FREQUENCY; GENE LOCATION; GENE LOCUS; GENETIC CONSERVATION; GENETIC POLYMORPHISM; GENETIC TRAIT; GENETIC VARIABILITY; GREECE; HEREDITY; HUMAN; ITALY; LACTOSE TOLERANCE; MICROSATELLITE MARKER; PREDICTION; PRIORITY JOURNAL;

ALLELES; FEMALE; GENETIC VARIATION; GENETICS, POPULATION; GENOTYPE; GREECE; HAPLOTYPES; HUMANS; ITALY; LACTASE; LACTOSE INTOLERANCE; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 65449151765     PISSN: 10420533     EISSN: 15206300     Source Type: Journal    
DOI: 10.1002/ajhb.20851     Document Type: Article

References (17)

1. Ammerman AJ, Cavalli-Sforza LL. 1984. The Neolithic transition and the genetics of populations in Europe. Princeton, NJ: Princeton University Press.
2. Beja-Pereira A, Luikart G, England PR, Bradley DG, Jann OC, Bertorelle G, Chamberlain AT, Nunes TP, Metodiev S, Ferrand N, Erhardt G. 2003. Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nat Genet 35:311-313.
3. Capelli C. 2007. The genetic history of Italy: a male prespective. J Anthropol Sci 85:3-4.
4. Cavalli-Sforza LL, Strata A, Barone A, Cucurachi L. 1987. Primary adult lactose malabsorption in Italy: regional differences in prevalence and relationship to lactose intolerance and milk consumption. Am J Clin Nutr 45:748-754.
5. Coelho M, Luiselli D, Bertorelle G, Lopes AI, Seixas S, Destro-Bisol G, Rocha J. 2005. Microsatellite variation and evolution of human lactase persistence. Hum Genet 117:329-339.
6. Destro-Bisol G, Anagnostou P, Batini P, Battaglia C, Bertoncini S, Bottini A, Caciagli L, Calò CM, Capelli C, Capocasa M, Castrz̀ L, Ciani G, Coia V, Corrias L, Crivellaro L, Ghiani ME, Luiselli D, Mela C, Melis A, Montano V, Paoli G, Sanna E, Rufo F, Spazzini M, Taglioli L, Tofanelli S, Useli A, Vona G, Pettener D. 2008. Italian isolates today: geographic and linguistic factors shaping human biodiversity. J Anthropol Sci 86:179-188.
7. Di Giacomo F, Luca F, Anagnou N, Ciavarella G, Corbo RM, Cresta M, Cucci F, Di Stasi L, Agostiano V, Giparaki M, Loutradis A, Mammi' C, Michalodimitrakis EN, Papola F, Pedicini G, Plata E, Terrenato L, Tofanelli S, Malaspina P, Novelletto A. 2003. Clinal patterns of human Y chromosomal diversity in continental Italy and Greece are dominated by drift and founder effects. Mol Phylogenet Evol 28:387-395.
8. Durham W. 1991. Coevolution: genes, culture and human diversity. Stanford, CA: Stanford University Press.
9. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I. 2002. Identification of a variant associated with adult-type hypolactasia. Nat Genet 30:233-237.
10. Flatz G. 1987. Genetics of lactose digestion in humans. Adv Hum Genet 16:1-77.
11. Francalacci P, Sanna D. 2008. History and geography of human Y-chromosome in Europe: a SNP perspective. J Anthropol Sci 86:59-89.
12. Hogenauer C, Hammer HF, Mellitzer K, Renner W, Krejs GJ, Toplak H. 2005. Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol 17:371-376.
13. Kelley JL, Swanson WJ. 2008. Positive selection in the human genome: from genome scans to biological significance. Annu Rev Genomics Hum Genet 9:143-160.
14. Piazza A, Cappello N, Olivetti E, Rendine S. 1988. A genetic history of Italy. Ann Hum Genet 52:203-213.
15. Sahi T. 1994. Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol Suppl 202:7-20.
16. Simoons FJ. 1969. Primary adult lactose intolerance and the milking habit: a problem in biological and cultural interrelations. I. Review of the medical research. Am J Dig Dis 14:819-836.
17. Slatkin M, Bertorelle G. 2001. The use of intraallelic variability for testing neutrality and estimating population growth rate. Genetics 158:865-874.