Reappraising the phototoxicity of tretinoin: A report of four controlled clinical trials

Photodermatology Photoimmunology and Photomedicine

Volumn 25, Issue 3, 2009, Pages 146-152

  Slade, Herbert B ^a,b   Shroot, Braham ^c   Feldman, Steven R ^d   Cargill, D Innes ^a,b   Stanfield, Joe ^e  

^a DFB Pharmaceuticals   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^c Barrier Therapeutics   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e Suncare Research Laboratories   (United States)

Author keywords

Photoallergenicity; Phototoxicity; Retinoids; Tretinoin

Indexed keywords

ATRALIN GEL; RETINOIC ACID; UNCLASSIFIED DRUG; WHITE PETROLATUM;

ADULT; AGED; APPLICATION SITE ERYTHEMA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EXPOSURE; DRUG FORMULATION; DRUG RESPONSE; FEMALE; GEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHOTOALLERGY; PHOTOTOXICITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION;

ADULT; AGED; DERMATITIS, PHOTOTOXIC; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TRETINOIN;

EID: 65449149374     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2009.00433.x     Document Type: Article

References (28)

1. Fu PP, Cheng SH, Coop L, et al. Photoreaction, phototoxicity, and photocarcinogenicity of retinoids. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2003; 21: 165-197.
2. Yashar SS, Lim HW. Classification and evaluation of photodermatoses. Dermatol Ther 2003; 16: 1-7.
3. Shroot B. Further light is shed on topical therapy. J Invest Dermatol 2003; 121: Xiii-xiv.
4. Wolf G. A history of vitamin A and retinoids. FASEB J 1996; 10: 1102-1107.
5. Moore DE. Drug-induced cutaneous photosensitivity: Incidence, mechanism, prevention and management. Drug Saf 2002; 25: 345-372.
6. Tolleson WH, Cherng SH, Xia Q, et al. Photodecomposition and phototoxicity of natural retinoids. Int J Environ Res Public Health 2005; 2: 147-155.
7. Stein KR, Scheinfeld NS. Drug-induced photoallergic and phototoxic reactions. Expert Opin Drug Saf 2007; 6: 431-443.
8. Kang S, Voorhees JJ. Photoaging therapy with topical tretinoin: An evidence-based analysis. J Am Acad Dermatol 1998; 39: S55-S61.
9. Morison WL, McAuliffe DJ, Parrish JA, Bloch KJ. In vitro assay for phototoxic chemicals. J Invest Dermatol 1982; 78: 460-463.
10. Kraemer KH, Waters HL, Cohen LF, et al. Effects of 8-methoxypsoralen and ultraviolet radiation on human lymphoid cells in vitro. J Invest Dermatol 1981; 76: 80-87.
11. Ferguson J, Johnson BE. Photosensitivity due to retinoids: Clinical and laboratory studies. Br J Dermatol 1986; 115: 275-283.
12. Pedace FJ, Stoughton R. Topical retinoic acid in acne vulgaris. Br J Dermatol 1971; 84: 465-469.
13. Birner AM, Meyer LP. Photosensitivity associated with fluorouracil, prochlorperazine, and topical tretinoin. Pharmacotherapy 2001; 21: 258-260.
14. Elias PM. Topical retinoic acid, aging, and the skin. West J Med 1988; 149: 766-767.
15. Epstein JH, Grekin DA. The effect of chronic applications of tretinoin (retinoic acid) on acute responses of mammalian skin to UVB radiation in vivo. Photochem Photobiol 1981; 33: 265-266.
16. Juhlin L, Shroot B. Intensity and area increase of UVB-induced erythema: two variables used for studies of the influence of topically applied drugs. Acta Derm Venereol 1993; 73: 273-275.
17. Smit JV, de Jong EM, de Jongh GJ, van de Kerkhof PC. Topical all-trans retinoic acid does not influence minimal erythema doses for UVB light in normal skin. Acta Derm Venereol 2000; 80: 66-67.
18. Papa CM. The cutaneous safety of topical tretinoin. Acta Derm Venereol Suppl (Stockholm) 1975; 74: 128-132.
19. FDA Center for Drug Evaluation and Research. Approval package for application number 020475, tradename Retin-A Micro Microsphere 0.1%. NDA Approval. 1997.
20. Sambuco CP, Forbes PD. Interactions of ultraviolet radiation, 12-O -tetradecanoyl-phorbol-13-acetate and retinoic acid in the skin of hairless mice. Food Chem Toxicol 1983; 21: 595-600.
21. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ. Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study. JAMA 1988; 259: 527-532.
22. Rittie L, Varani J, Kang S, Voorhees JJ, Fisher GJ. Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol 2006; 126: 732-739.
23. Plewig G, Braun-Falco O. Kinetics of epidermis and adnexa following vitamin A acid in the human. Acta Derm Venereol Suppl (Stockholm) 1975; 74: 87-98.
24. Lehmann P, Melnik B, Holzle E, Neumann N, Plewig G. The effect of UV-A and UV-B irradiation on the skin barrier. Skin physiologic, electron microscopy and lipid biochemistry studies. Hautarzt 1992; 43: 344-351.
25. Eckhart L, Schmidt M, Mildner M., et al. Histidase expression in human epidermal keratinocytes: Regulation by differentiation status and all-trans retinoic acid. J Dermatol Sci 2008; 50: 209-215.
26. Baden HP, Hori Y, Pathak MA, Levy HL. Epidermis in histidinemia. Arch Dermatol 1969; 100: 432-435.
27. Levy HL, Baden HP, Shih VE. A simple indirect method of detecting the enzyme defect in histidinemia. J Pediatr 1969; 75: 1056-1058.
28. Lam WK, Cleary MA, Wraith JE, Walter JH. Histidinaemia: A benign metabolic disorder. Arch Dis Child 1996; 74: 343-346.