The role of immunohistochemistry in idiopathic chronic intestinal pseudoobstruction (CIPO): A case-control study

American Journal of Surgical Pathology

Volumn 33, Issue 5, 2009, Pages 749-758

  Amiot, Aurelien ^a,b   Cazals Hatem, Dominique ^b   Joly, Francisca ^a   Lavergne Slove, Anne ^c   Peuchmaur, Michel ^d   Bouhnik, Yoram ^a   Bedossa, Pierre ^b   Messing, Bernard ^a  

^a Unité de Gastroentérologie et d'Assistance Nutritive   (France)

^b BEAUJON HOSPITAL   (France)

^c HÔPITAL LARIBOISIÈRE   (France)

^d HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

CD117; Chronic intestinal pseudoobstruction, interstitial Cajal cells; Ganglion cells; Hu C D antibody

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; DESMIN; HU PROTEIN; PROTEIN ANTIBODY; PROTEIN BCL 2; PROTEIN S 100; SMOOTHELIN; STEM CELL FACTOR RECEPTOR; ACTIN; COLORING AGENT; CYTOSKELETON PROTEIN; DIAGNOSTIC AGENT; ELAVL3 PROTEIN, HUMAN; ELAVL4 PROTEIN, HUMAN; EOSIN; HEMATOXYLIN; HU ANTIGEN; MUSCLE PROTEIN; SMTN PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHRONIC DISEASE; CHRONIC INTESTINAL PSEUDOOBSTRUCTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPOGANGLIONOSIS; IDIOPATHIC DISEASE; ILEUM; IMMUNOHISTOCHEMISTRY; INFANT; INTERMETHOD COMPARISON; INTERSTITIAL CELL OF CAJAL; INTESTINAL DYSMOTILITY; INTESTINE INNERVATION; INTESTINE OBSTRUCTION; MALE; MYOPATHY; NERVE CELL; NEUROLOGIC DISEASE; NEUROMUSCULAR DISEASE; NEUROPATHY; PRESCHOOL CHILD; SCHOOL CHILD; CASE CONTROL STUDY; CHEMISTRY; EVALUATION; INTESTINE; INTESTINE PSEUDOOBSTRUCTION; MESODERM; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING; SMOOTH MUSCLE; STAINING;

ACTINS; ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; COLORING AGENTS; CYTOSKELETAL PROTEINS; DESMIN; EOSINE YELLOWISH-(YS); FEMALE; HEMATOXYLIN; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INTESTINAL PSEUDO-OBSTRUCTION; INTESTINES; MALE; MESODERM; MIDDLE AGED; MUSCLE PROTEINS; MUSCLE, SMOOTH; NEURONS; PREDICTIVE VALUE OF TESTS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-KIT; S100 PROTEINS; STAINING AND LABELING; YOUNG ADULT;

EID: 65449145512     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31819b381a     Document Type: Article

References (50)

1. Alstead EM, Murphy MN, Flanagan AM, et al. Familial autonomic visceral myopathy with degeneration of muscularis mucosae. J Clin Pathol. 1988;41:424-429.
2. Barbara G, Stanghellini V, De Giorgio R, et al. Functional gastrointestinal disorders and mast cells: implications for therapy. Neurogastroenterol Motil. 2006;18:6-17.
3. Chang IY, Glasgow NJ, Takayama I, et al. Loss of interstitial cells of Cajal and development of electrical dysfunction in murine small bowel obstruction. J Physiol. 2001;536:555-568.
4. Christen T, Verin V, Bochaton-Piallat M, et al. Mechanisms of neointima formation and remodeling in the porcine coronary artery. Circulation. 2001;103:882-888.
5. Connor FL, Di Lorenzo C. Chronic intestinal pseudo-obstruction: assessment and management. Gastroenterology. 2006;130:S29-S36.
6. Dalmau J, Furneaux HM, Cordon-Cardo C, et al. The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues. Am J Pathol. 1992; 141:881-886.
7. De Giorgio R, Guerrini S, Barbara G, et al. New insights into human enteric neuropathies. Neurogastroenterol Motil. 2004; 16(suppl 1):143-147.
8. De Giorgio R, Sarnelli G, Corinaldesi R, et al. Advances in our understanding of the pathology of chronic intestinal pseudoobstruction. Gut. 2004;53:1549-1552.
9. Feldstein AE, Miller SM, El-Youssef M, et al. Chronic intestinal pseudoobstruction associated with altered interstitial cells of Cajal networks. J Pediatr Gastroenterol Nutr. 2003;36:492-497.
10. Fitzgibbons PL, Chandrasoma PT. Familial visceral myopathy. Evidence of diffuse involvement of intestinal smooth muscle. Am J Surg Pathol. 1987;11:846-854.
11. Gamba E, Carr NJ, Bateman AC. Deficient alpha smooth muscle actin expression as a cause of intestinal pseudo-obstruction: fact or fiction? J Clin Pathol. 2004;57:1168-1171.
12. Goyal RK, Hirano I. The enteric nervous system. N Engl J Med. 1996;334:1106-1115.
13. Graus F, Cordon-Cardo C, Posner JB. Neuronal antinuclear antibody in sensory neuronopathy from lung cancer. Neurology. 1985;35:538-543.
14. He SH. Key role of mast cells and their major secretory products in inflammatory bowel disease. World J Gastroenterol. 2004;10: 309-318.
15. Hockenbery DM, Zutter M, Hickey W, et al. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA. 1991;88:6961-6965.
16. Isozaki K, Hirota S, Miyagawa J, et al. Deficiency of c-kit+ cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol. 1997;92:332-334.
17. Jain D, Moussa K, Tandon M, et al. Role of interstitial cells of Cajal in motility disorders of the bowel. Am J Gastroenterol. 2003;98: 618-624.
18. Joly F, Amiot A, Coffin B, et al. Chronic intestinal pseudoobstruction. Gastroenterol Clin Biol. 2006;30:975-985.
19. Joly F, Amiot A, Messing B. Chronic intestinal pseudo-obstruction. In: Bozzetti F, Staun M, Van Gossum A, eds. Home Parenteral Nutrition. Oxford: Oxford University Press; 2007:84-94.
20. King T, Biddle W, Bhatia P, et al. Colonic mucosal mast cell distribution at line of demarcation of active ulcerative colitis. Dig Dis Sci. 1992;37:490-495.
21. Knowles CH, Silk DB, Darzi A, et al. Deranged smooth muscle alpha-actin as a biomarker of intestinal pseudo-obstruction: a controlled multinational case series. Gut. 2004;53:1583-1589.
22. Korsmeyer SJ, McDonnell TJ, Nunez G, et al. Bcl-2: B cell life, death and neoplasia. Curr Top Microbiol Immunol. 1990;166:203-207.
23. Krishnamurthy S, Schuffler MD. Pathology of neuromuscular disorders of the small intestine and colon. Gastroenterology. 1987;93: 610-639.
24. Lee HT, Hennig GW, Fleming NW, et al. Septal interstitial cells of Cajal conduct pacemaker activity to excite muscle bundles in human jejunum. Gastroenterology. 2007;133:907-917.
25. Lee JC, Thuneberg L, Berezin I, et al. Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal. Am J Physiol. 1999;277:G409-G423.
26. Lin Z, Gao N, Hu HZ, et al. Immunoreactivity of Hu proteins facilitates identification of myenteric neurons in guinea-pig small intestine. Neurogastroenterol Motil. 2002;14:197-204.
27. Lyford GL, He CL, Soffer E, et al. Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut. 2002;51:496-501.
28. Mann SD, Debinski HS, Kamm MA. Clinical characteristics of chronic idiopathic intestinal pseudo-obstruction in adults. Gut. 1997;41:675-681.
29. Merry DE, Veis DJ, Hickey WF, et al. bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development. 1994;120:301-311.
30. Mitros FA, Schuffler MD, Teja K, et al. Pathologic features of familial visceral myopathy. Hum Pathol. 1982;13:825-833.
31. Moore SW, Schneider JW, Kaschula RO. Unusual variations of gastrointestinal smooth muscle abnormalities associated with chronic intestinal pseudo-obstruction. Pediatr Surg Int. 2002;18:13-20.
32. Murphy EM, Defontgalland D, Costa M, et al. Quantification of subclasses of human colonic myenteric neurons by immunoreactivity to Hu, choline acetyltransferase and nitric oxide synthase. Neurogastroenterol Motil. 2007;19:126-134.
33. Niessen P, Clement S, Fontao L, et al. Biochemical evidence for interaction between smoothelin and filamentous actin. Exp Cell Res. 2004;292:170-178.
34. Niessen P, Rensen S, van Deursen J, et al. Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology. 2005;129:1592-1601.
35. Phillips RJ, Hargrave SL, Rhodes BS, et al. Quantification of neurons in the myenteric plexus: an evaluation of putative panneuronal markers. J Neurosci Methods. 2004;133:99-107.
36. Rensen SS, Thijssen VL, De Vries CJ, et al. Expression of the smoothelin gene is mediated by alternative promoters. Cardiovasc Res. 2002;55:850-863.
37. Robinson TL, Sircar K, Hewlett BR, et al. Gastrointestinal stromal tumors may originate from a subset of CD34-positive interstitial cells of Cajal. Am J Pathol. 2000;156:1157-1163.
38. Rudolph CD, Hyman PE, Altschuler SM, et al. Diagnosis and treatment of chronic intestinal pseudo-obstruction in children: report of consensus workshop. J Pediatr Gastroenterol Nutr. 1997; 24:102-112.
39. Schuffler MD, Lowe MC, Bill AH. Studies of idiopathic intestinal pseudoobstruction. I. Hereditary hollow visceral myopathy: clinical and pathological studies. Gastroenterology. 1977;73:327-338.
40. Schuffler MD, Rohrmann CA, Chaffee RG, et al. Chronic intestinal pseudo-obstruction. A report of 27 cases and review of the literature. Medicine (Baltimore). 1981;60:173-196.
41. Smith VV, Milla PJ. Histological phenotypes of enteric smooth muscle disease causing functional intestinal obstruction in childhood. Histopathology. 1997;31:112-122.
42. Stanghellini V, Camilleri M, Malagelada JR. Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings. Gut. 1987;28:5-12.
43. Stanghellini V, Cogliandro RF, de Giorgio R, et al. Chronic intestinal pseudo-obstruction: manifestations, natural history and management. Neurogastroenterol Motil. 2007;19:440-452.
44. Streutker CJ, Huizinga JD, Campbell F, et al. Loss of CD117 (c-kit)- and CD34-positive ICC and associated CD34-positive fibroblasts defines a subpopulation of chronic intestinal pseudoobstruction. Am J Surg Pathol. 2003;27:228-235.
45. The FO, Bennink RJ, Ankum WM, et al. Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus. Gut. 2008;57:33-40.
46. Thomsen L, Robinson TL, Lee JC, et al. Interstitial cells of Cajal generate a rhythmic pacemaker current. Nat Med. 1998;4: 848-851.
47. van der Loop FT, Schaart G, Timmer ED, et al. Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells. J Cell Biol. 1996;134:401-411.
48. Ward SM, Sanders KM. Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. Am J Physiol Gastrointest Liver Physiol. 2001;281:G602-G611.
49. Wedel T, Van Eys GJ, Waltregny D, et al. Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Neurogastroenterol Motil. 2006;18:526-538.
50. Won KJ, Suzuki T, Hori M, et al. Motility disorder in experimentally obstructed intestine: relationship between muscularis inflammation and disruption of the ICC network. Neurogastroenterol Motil. 2006;18:53-61.