A randomized prospective study of insulin pump vs. insulin injection therapy in very young children with type 1 diabetes: 12-month glycemic, BMI, and neurocognitive outcomes

Pediatric Diabetes

Volumn 10, Issue 3, 2009, Pages 202-208

  Nabhan, Zeina M ^a   Kreher, Nerissa C ^a   Greene, Dennis M ^b   Eugster, Erica A ^a   Kronenberger, William ^a   DiMeglio, Linda A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Meridian Psychological Associates   (United States)

Author keywords

Gycemic control; Insulin pump therapy; Neurocognitive function; Parental stress; T1DM; Toddlers

Indexed keywords

HEMOGLOBIN A1C; INSULIN;

ARTICLE; BODY MASS; CHILD; CHILD BEHAVIOR; CHILD BEHAVIOR CHECKLIST; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN INFUSION; INSULIN PUMP; INSULIN TREATMENT; MALE; NEUTRAL INSULIN INJECTION; PARENTAL BEHAVIOR; PARENTAL STRESS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STANFORD-BINET INTELLIGENCE SCALE;

BLOOD GLUCOSE; BODY MASS INDEX; CHILD BEHAVIOR; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; INSULIN INFUSION SYSTEMS; MALE; PARENT-CHILD RELATIONS; PARENTING; PATIENT EDUCATION AS TOPIC; PROSPECTIVE STUDIES; REINFORCEMENT (PSYCHOLOGY); SOCIAL ADJUSTMENT; STRESS, PSYCHOLOGICAL; TREATMENT OUTCOME;

EID: 65449143254     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2008.00494.x     Document Type: Article

References (38)

1. The Diabetes Control and Complications Trial and Research Group. The effect of intensive diabetes treatment on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993: 329: 977-986.
2. Nathan DM, Cleary PA, Backlund JY et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005: 353: 2643-2653.
3. Pickup J, Mattock M, Kerry S. Glycaemic control with subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: Meta-analysis of randomized controlled trials. BMJ 2002: 324: 705-710.
4. Weissberg-Benchell J, Antisdel-Lomaglio J, Seshadri R. Insulin pump therapy: A meta-analysis. Diabetes Care 2003: 26: 1079-1087.
5. Linkeschova R, Raoul M, Bott U, Berger M, Spraul M. Less severe hypoglycemia, better metabolic control, and improved quality of life in type 1 diabetes mellitus with continuous subcutaneous insulin infusion (CSII) therapy; an observational study of 100 consecutive patients followed for a mean of 2 years. Diabet Med 2002: 19: 746-751.
6. Tubiana-rufi N, De Lonlay P, Bloch J et al. Remission of severe hypoglycemia incidents in young children treated with subcutaneous infusion. Arch Pediatr 1996: 3: 969-976.
7. Litton J, Rice A, Freidman N et al. Insulin pump therapy in toddlers and preschool children with type 1 diabetes mellitus. J Pediatr 2002: 141: 490-495.
8. Shehadeh N, Battelino T, Gelatzer A et al. Insulin pump therapy for 1-6 year old children with type 1 diabetes. Isr Med Assoc J 2004: 6: 284-286.
9. Ahern JH, Boland EA, Doane R et al. Insulin pump therapy in pediatrics: a therapeutic alternative to safely lower HbA1c levels across all age groups. Pediatr Diabetes 2002: 3: 10-15.
10. Weinzimer SA, Ahern JA, Doyle EA et al. Persistence of benefits of continuous subcutaneous insulin infusion in very young children with type 1 diabetes: A follow-up report. Pediatrics 2004: 114: 1601-1605.
11. Di Meglio LA, Pottorff TM, Boyd SR et al. A randomized, controlled study of insulin pump therapy in diabetic preschoolers. J Pediatr 2004: 145: 380-384.
12. Fox LA, Buckloh LM, Smith SD et al. A randomized controlled trial of insulin pump therapy in young children with type 1 diabetes. Diabetes Care 2005: 28: 1277-1281.
13. Wilson DM, Buckingham BA, Kunselman EL et al. A two-center randomized controlled feasibility trial of insulin pump therapy in young children with diabetes. Diabetes Care 2005: 28: 15-19.
14. Gaudieri PA, Chen R, Greer T et al. Cognitive function in children with type 1 diabetes - a meta-analysis. Diabetes Care 2008: 31: 1892-1897.
15. Holmes CS, Cant MC, Fox MA, Lampert NL, Greer T. Disease and demographic risk factors for disrupted cognitive functioning in children with insulin-dependent diabetes mellitus (IDDM). School Psych Rev 1999: 28: 215-227.
16. Ryan C, Vega A, Drash A. Cognitive deficits in adolescents who developed diabetes early in life. Pediatrics 1985: 75: 921.
17. Hershey T, Perantie DC, Warren SL, Zimmerman EC, Sadler M, White NH. Frequency and timing of severe hypoglycemia affects spatial memory in children with type 1 diabetes. Diabetes Care 2005: 28: 2372-2377.
18. Perantie DC, Lim A, Wu J et al. Effects of prior hypoglycemia and hyperglycemia on cognition in children with type 1 diabetes. Pediatr Diabetes 2008: 9: 87-95.
19. Northam E, Anderson P, Adler R, Werther G, Warne G. Psychosocial and family functioning in children with insulin-dependent diabetes at diagnosis and one year later. J Pediatr Psychol 1996: 21: 699-717.
20. Sullivan-Bolyai S, Deatrick J, Gruppuso P, Tamborlane W, Grey M. Mothers' experience raising young children with type 1 diabetes. J Soc Pediatr Nurs 2002: 7: 93-103.
21. Sullivan-Bolyai S, Deatrick J, Gruppuso P, Tamborlane W, Grey M. Constant vigilance: Mothers'work parenting young children with type 1 diabetes. J Pediatr Nurs 2003: 18: 21-29.
22. Opipari-Arrigan L, Fredricks EM, Burkhart N et al. Continuous subcutaneous insulin infusion benefits quality of life in preschool-age children with type 1 diabetes mellitus. Pediatr Diabetes 2007: 8: 377-383.
23. Thorndike RL, Hagen EP, Sattler JM. Guide for Administering and Scoring the Stanford-Binet Intelligence Scale: Fourth Edition. Chicago: Riverside, 1986.
24. Beery KE. The Beery-Buktenica Developmental Test of Visual Motor Integration, 4th edn (Revised). Parsippany, NJ: Modern Curriculum Press, 1997.
25. Abidin RR. Parenting Stress Index Professional Manual, 3rd edn. Odessa, FL: Psychological Assessment Resources, 1995: 75.
26. Achenbach TM. Manual for the Child Behavior Checklist/4-18 and 1991 Profile. Burlington, VT: University of Vermont Department of Psychiatry, 1991.
27. Achenbach TM. Manual for the Child Behavior Checklist/2-3 and 1992 Profile. Burlington, VT: University of Vermont Department of Psychiatry, 1992.
28. USDA/ARS Children's Nutrition Research center. Children's BMI and Percentile Graph calculator 2003 (available from http://www.kidsnutrition.org/bodycomp/bmiz2.html).
29. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM et al. CDC growth charts: United States. Adv Data 2000: 314: 1-27.
30. Willi SM, Planton J, Egede L, Schwarz S. Benefits of continuous subcutaneous insulin infusion in children with type 1 diabetes. J Pediatr 2003: 143: 796-801.
31. Weintrob N, Benzaquen H, Galatzer A et al. Comparison of continuous subcutaneous insulin infusion and multiple daily injection regimens in children with type 1 diabetes: A randomized open crossover trial. Pediatrics 2003: 112: 559-564.
32. Holmes CS, Richman LC. Cognitive profiles of children with insulin-dependent diabetes. J Dev Behav Pediatr 1985: 6: 323-326.
33. Desrocher M, Rovet J. Neurocognitive correlates of type 1 diabetes mellitus in childhood. Child Neuropsychol 2004: 10: 36-42.
34. Valenzuela JM, Patino AM, Mc Cullough J et al. Insulin pump therapy and health related quality of life in children and adolescents with type 1 diabetes. J Pediatr Psychol 2006: 31: 650-660.
35. Boland EA, Grey M, Oesterle A, Fredrickson L, Tamborlane WV. Continuous subcutaneous insulin infusion: A new way to lower risk of severe hypoglycemia, improve metabolic control, and enhance coping in adolescents with type 1 diabetes. Diabetes Care 1999: 22: 1779-1784.
36. Seigler DE, La Greca A, Citrin WS, Reeves ML, Skyler JS. Psychological effects of intensification of diabetic control. Diabetes Care 1982: 5(Suppl. 1): 19-23.
37. Hauenstein EJ, Marvin RS, Snyder AL, Clarke WL. Stress in parents of children with diabetes mellitus. Diabetes Care 1989: 12: 18-23.
38. Jeha GS, Karaviti LP, Anderson B et al. Insulin pump therapy in preschool children with type 1 diabetes mellitus improves glycemic control and decreases glucose excursion and the risk of hypoglycemia. Diabetes Technol Ther 2005: 7: 876-884.