Folic acid supplementation: Too much of a good thing?

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 80, Issue 5, 2009, Pages 468-

  Hauser, W Allen ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; FOLIC ACID; HOMOCYSTEINE; VALPROIC ACID; ANTICONVULSIVE AGENT; VITAMIN;

ARTERY INTIMA PROLIFERATION; CLEFT LIP; CLEFT PALATE; DIET SUPPLEMENTATION; DRUG MEGADOSE; EDITORIAL; EPILEPSY; HUMAN; NEURAL TUBE DEFECT; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RESTENOSIS; VITAMIN SUPPLEMENTATION; ADULT; CONGENITAL MALFORMATION; FEMALE; NEWBORN; NOTE; PREGNANCY;

ABNORMALITIES, DRUG-INDUCED; ADULT; ANTICONVULSANTS; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HUMANS; INFANT, NEWBORN; PREGNANCY; VITAMINS; YOUNG ADULT;

EID: 65449132464     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2008.169516     Document Type: Editorial

References (11)

1. Morrow JI, Hunt SJ, Russell AJ, et al. Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2009;80:506-11.
2. Omtzigt JG, Los FJ, Grobbee DE, et al. The risk of spina bifida aperta after first trimester exposure to valproate in a prenatal cohort. Neurology 1992;4:119-25.
3. Rosa FW. Spina bifida in infants of women treated with carbamazepine during pregnancy. N Engl J Med 1991;324:674-7.
4. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7.
5. Czeizel A, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-5. (Pubitemid 23003073)
6. Godwin KA, Sibbald B, Bedard T, et al. Changes in frequencies of select congenital anomalies since the onset of folic acid fortification in a Canadian birth defect registry. Can J Public Health 2008;99:271-5.
7. Boulet SL, Yang Q, Mai C, et al. Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. Birth Defects Res A Clin Mol Teratol 2008;82:527-32.
8. Wilcox AJ, Lie RT, Solvoll K, et al. Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ 2007;334:464. (Pubitemid 46586604)
9. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. (Pubitemid 38788002)
10. Bønaa KH, Njølstad I, Ueland PM, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006;354:1578-88.
11. Baggott JE, Vaughn WH, Juliana MM, et al. Effects of folate deficiency and supplementation on methylnitrosourea-induced rat mammary tumors. J Natl Cancer Inst 1992;84:1740-4.