Inflammatory cutaneous adverse effects of methylene blue dye injection for lymphatic mapping/sentinel lymphadenectomy

Journal of Surgical Oncology

Volumn 99, Issue 6, 2009, Pages 356-360

  Bleicher, Richard J ^a   Kloth, Dwight D ^a   Robinson, Darlene ^a   Axelrod, Peter ^b  

^a FOX CHASE CANCER CENTER   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blue; Coloring agents; Complications; Diagnostic techniques; Diagnostic use; Methylene; Sentinel lymph node biopsy; Surgical

Indexed keywords

ISOSULFAN BLUE; METHYLENE BLUE; COLORING AGENT; CONTRAST MEDIUM; DIAGNOSTIC AGENT; FUCHSINE; ISO SULFAN BLUE; ISO-SULFAN BLUE;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER STAGING; CELLULITIS; CONSERVATIVE TREATMENT; CONTROLLED STUDY; FAT NECROSIS; FEMALE; HUMAN; INJECTION SITE ERYTHEMA; INJECTION SITE NECROSIS; INJECTION SITE PAIN; LYMPHADENECTOMY; LYMPHATIC MAPPING; LYMPHOGRAPHY; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MELANOMA; PRIORITY JOURNAL; SENTINEL LYMPH NODE; SENTINEL LYMPHADENECTOMY; SKIN INFLAMMATION; SKIN MANIFESTATION; SKIN NECROSIS; SKIN PRURITUS; TELANGIECTASIA; BREAST TUMOR; CASE REPORT; CHEMICALLY INDUCED DISORDER; DIFFERENTIAL DIAGNOSIS; DRUG EFFECT; INFLAMMATION; METHODOLOGY; MICROBIOLOGY; MIDDLE AGED; SENTINEL LYMPH NODE BIOPSY; SKIN; SKIN TUMOR;

AGED, 80 AND OVER; BREAST NEOPLASMS; CELLULITIS; COLORING AGENTS; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; INFLAMMATION; MELANOMA; METHYLENE BLUE; MIDDLE AGED; ROSANILINE DYES; SENTINEL LYMPH NODE BIOPSY; SKIN; SKIN NEOPLASMS;

EID: 65449123542     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21240     Document Type: Article

References (24)

1. Giuliano AE, Kirgan DM, Guenther JM, et al.: Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 1994;220:391-398; discussion 398-401.
2. Morton DL, Wen DR, Wong JH, et al.: Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992;127:392-399.
3. Wong JH, Cagle LA, Morton DL: Lymphatic drainage of skin to a sentinel lymph node in a feline model. Ann Surg 1991;214:637-641.
4. Simmons RM, Smith SM, Osborne MP: Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization. Breast J 2001;7:181-183. (Pubitemid 32619780)
5. Blessing WD, Stolier AJ, Teng SC, et al.: A comparison of methylene blue and lymphazurin in breast cancer sentinel node mapping. Am J Surg 2002;184:341-345.
6. Simmons R, Thevarajah S, Brennan MB, et al.: Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization. Ann Surg Oncol 2003;10:242-247.
7. Stradling B, Aranha G, Gabram S: Adverse skin lesions after methylene blue injections for sentinel lymph node localization. Am J Surg 2002;184:350-352. (Pubitemid 35287358)
8. Nour A: Efficacy of methylene blue dye in localization of sentinel lymph node in breast cancer patients. Breast J 2004;10:388-391. (Pubitemid 39281309)
9. Golshan M, Nakhlis F: Can methylene blue only be used in sentinel lymph node biopsy for breast cancer? Breast J 2006;12:428-430.
10. Cundiff JD, Wang YZ, Espenan G, et al.: A phase I/II trial of 125I methylene blue for one-stage sentinel lymph node biopsy. Ann Surg 2007;245:290-296.
11. Varghese P, Abdel-Rahman AT, Akberali S, et al.: Methylene blue dye - A safe and effective alternative for sentinel lymph node localization. Breast J 2008;14:61-67.
12. Zakaria S, Hoskin TL, Degnim AC: Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer. Am J Surg 2008;196:228-233.
13. Salhab M, Al Sarakbi W, Mokbel K: Skin and fat necrosis of the breast following methylene blue dye injection for sentinel node biopsy in a patient with breast cancer. Int Semin Surg Oncol 2005;2:26. (Pubitemid 41762768)
14. O'Sullivan MJ, Morrow M: Images in clinical medicine. Blue hives. N Engl J Med 2008;358:e6.
15. Wilke LG, McCall LM, Posther KE, et al.: Surgical complications associated with sentinel lymph node biopsy: Results from a prospective international cooperative group trial. Ann Surg Oncol 2006;13:491-500.
16. Singh-Ranger G, Mokbel K: Capsular contraction following immediate reconstructive surgery for breast cancer - An association with methylene blue dye. Int Semin Surg Oncol 2004;1:3. (Pubitemid 39112042)
17. Methylene blue - PubChem Public Chemical Database. In "PubChem Public Chemical Database".
18. Wishart GM: On the reduction of methylene blue by tissue extracts. Biochem J 1923;17:103-114.
19. Rehman HU: Methemoglobinemia. West J Med 2001;175:193-196.
20. Passow H, Rothstein A, Loewenstein B: An all-or none response in the release of potassium by yeast cells with methylene blue and other basic redox dyes. J Gen Physiol 1959;43:97-107.
21. Armstrong CM, Croop RS: Simulation of Na channel inactivation by thiazine dyes. J Gen Physiol 1982;80:641-662. (Pubitemid 13202073)
22. Gryglewski RJ, Zembowicz A, Salvemini D, et al.: Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin. Br J Pharmacol 1992;106:838-845.
23. Borgstein PJ, Meijer S, Pijpers RJ, et al.: Functional lymphatic anatomy for sentinel node biopsy in breast cancer: Echoes from the past and the periareolar blue method. Ann Surg 2000; 232: 81-89.
24. Tanis PJ, Nieweg OE, Valdes Olmos RA, et al.: Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy. J Am Coll Surg 2001;192:399-409.