Postoperative PMBC-derived IL-6 and TNF-alpha-release is uninfluenced by IL-12-mediated restoration of IFN-gamma synthesis

Scandinavian Cardiovascular Journal

Volumn 43, Issue 2, 2009, Pages 136-144

  Franke, Axel ^a   Lante, Wolfgang ^a   Kurig, Edmond ^a   Zoeller, Lothar G ^a   Kollig, Erwin ^a   Markewitz, Andreas ^a  

^a BUNDESWEHRZENTRALKRANKENHAUS KOBLENZ   (Germany)

Author keywords

Cardiac surgery; IFN gamma synthesis; Immune function; Interleukin 12; Major surgical trauma; T cell suppression

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; STAPHYLOCOCCUS ENTEROTOXIN B; TUMOR NECROSIS FACTOR ALPHA; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; IL10 PROTEIN, HUMAN; IL2 PROTEIN, HUMAN; IL4 PROTEIN, HUMAN; IL5 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ADULT; ARTICLE; CELL CULTURE; CELL STIMULATION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CYTOKINE RELEASE; FEMALE; HEART SURGERY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SUPERNATANT; SURGICAL PATIENT; CARDIOPULMONARY BYPASS; DRUG EFFECT; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; TIME;

CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; CELLS, CULTURED; ENTEROTOXINS; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKIN-5; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 65449122728     PISSN: 14017431     EISSN: 16512006     Source Type: Journal    
DOI: 10.1080/14017430802409699     Document Type: Article

References (23)

1. Markewitz A, Lante W, Franke A, Marohl K, Kuhlmann WD, Weinhold C. Alterations of cell-mediated immunity following cardiac operations: Clinical implications and open questions. Shock. 2001;16(Suppl 1):10-5.
2. Oczenski W, Krenn H, Jilch R, Watzka H, Waldenberger F, Koller U, et al. HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery. Intensive Care Med. 2003;29:1253-7.
3. Gu YJ, van Oeveren W. Time course of proinflammatory and anti-inflammatory responses after cardiac operation: Monocyte HLA-DR expression. Ann Thorac Surg. 2003;76:654-5; author reply 655-6.
4. Franke A, Lante W, Kollig E, Markewitz A. A comparison of monocyte counts and ex vivo and in vitro monocyte cytokine production after major surgical trauma. J Surg Res. 2008.
5. Franke A, Lante W, Zoeller LG, Kurig E, Weinhold C, Markewitz A. Delayed recovery of human leukocyte antigen-DR expression after cardiac surgery with early non-lethal postoperative complications: Only an epiphenomenon? Interact Cardiovasc Thorac Surg. 2007.
6. Franke A, Lante W, Kurig E, Zoller LG, Weinhold C, Markewitz A. Hyporesponsiveness of T cell subsets after cardiac surgery: A product of altered cell function or merely a result of absolute cell count changes in peripheral blood? Eur J Cardiothorac Surg. 2006;30:64-71.
7. Franke A, Lante W, Fackeldey V, Becker HP, Thode C, Kuhlmann WD, et al. Proinflammatory and antiinflammatory cytokines after cardiac operation: Different cellular sources at different times. Ann Thorac Surg. 2002;74:363-70; Discussion 370-61.
8. Franke A, Lante W, Markewitz A, Weinhold C. In vitro restoration of post-operatively decreased IFN-gamma levels after cardiac surgery and its effect on pro- and anti-inflammatory mediators. J Surg Res. 2006.
9. Franke A, Lante W, Kurig E, Zoller LG, Weinhold C, Markewitz A. Is interferon gamma suppression after cardiac surgery caused by a decreased interleukin-12 synthesis? Ann Thorac Surg. 2006;82:103-9.
10. Franke A, Lante W, Fackeldey V, Becker HP, Kurig E, Zoller LG, et al. Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: Is what we see what we know? Eur J Cardiothorac Surg. 2005;28:569-75.
11. Tarnok A, Schneider P. Pediatric cardiac surgery with cardiopulmonary bypass: Pathways contributing to transient systemic immune suppression. Shock. 2001;16(Suppl 1): 24-32.
12. Flohe S, Borgermann J, Lim L, Schade FU. Interferon-gamma counteracts reduced endotoxin responsiveness of whole blood following trauma and cardiopulmonary bypass. J Endotoxin Res. 2000;6:431-6.
13. Schinkel C, Licht K, Zedler S, Schinkel S, Fraunberger P, Fuchs D, et al. Interferon-gamma modifies cytokine release in vitro by monocytes from surgical patients. J Trauma. 2001; 50:321-7.
14. Sablotzki A, Dehne MG, Friedrich I, Grond S, Zickmann B, Muhling J, et al. Different expression of cytokines in survivors and non-survivors from MODS following cardiovascular surgery. Eur J Med Res. 2003;8:71-6.
15. Sablotzki A, Friedrich I, Muhling J, Dehne MG, Spillner J, Silber RE, et al. The systemic inflammatory response syndrome following cardiac surgery: Different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunctions. Perfusion. 2002;17: 103-9.
16. Kabir K, Keller H, Grass G, Minor T, Stueber F, Schroeder S, et al. Cytokines and chemokines in serum and urine as early predictors to identify septic patients on intensive care unit. Int J Mol Med. 2003;12:565-70.
17. Goebel A, Kavanagh E, Lyons A, Saporoschetz IB, Soberg C, Lederer JA, et al. Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann Surg. 2000;231:253-61.
18. Ono S, Ueno C, Aosasa S, Tsujimoto H, Seki S, Mochizuki H. Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis. Am J Surg. 2001;182:491-7.
19. Ono S, Ueno C, Seki S, Matsumoto A, Mochizuki H. Interleukin-12 and -18 induce severe liver injury in mice recovered from peritonitis after sublethal endotoxin challenge. Surgery. 2003;134:92-100.
20. Steinhauser ML, Hogaboam CM, Lukacs NW, Strieter RM, Kunkel SL. Multiple roles for IL-12 in a model of acute septic peritonitis. J Immunol. 1999;162:5437-43.
21. Volk HD, Reinke P, Krausch D, Zuckermann H, Asadullah K, Muller JM, et al. Monocyte deactivation--rationale for a new therapeutic strategy in sepsis. Intensive Care Med. 1996; 22(Suppl 4):S474-81.
22. Fantuzzi L, Puddu P, Varano B, Del Corno M, Belardelli F, Gessani S. IFN-alpha and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-gamma production in mouse macrophages: Novel pathways in the regulation of the inflammatory response of macrophages. J Leukoc Biol. 2000;68:707-14.
23. Cuesta N, Salkowski CA, Thomas KE, Vogel SN. Regulation of lipopolysaccharide sensitivity by IFN regulatory factor-2. J Immunol. 2003;170:5739-47.